A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese
Abstract BACKGROUND Nasopharyngeal carcinoma (NPC) is a rare disease in most populations; however, in areas of Southeast Asia and North Africa and in the Arctic, undifferentiated NPC is the most frequent pharyngeal malignancy. Although smoking and alcohol have been established firmly as synergistic...
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crwiley:10.1002/cncr.22501 2024-06-09T07:44:22+00:00 A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese Friborg, Jeppe T. Yuan, Jian‐Min Wang, Renwei Koh, Woon‐Puay Lee, Hin‐Peng Yu, Mimi C. 2007 http://dx.doi.org/10.1002/cncr.22501 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcncr.22501 https://onlinelibrary.wiley.com/doi/full/10.1002/cncr.22501 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Cancer volume 109, issue 6, page 1183-1191 ISSN 0008-543X 1097-0142 journal-article 2007 crwiley https://doi.org/10.1002/cncr.22501 2024-05-16T14:28:42Z Abstract BACKGROUND Nasopharyngeal carcinoma (NPC) is a rare disease in most populations; however, in areas of Southeast Asia and North Africa and in the Arctic, undifferentiated NPC is the most frequent pharyngeal malignancy. Although smoking and alcohol have been established firmly as synergistic risk factors for other pharyngeal carcinomas, previous studies on the association between these risk factors and NPC have not been consistent. Therefore, the authors analyzed this relation in a cohort of Singapore Chinese, which is a population with a high incidence of NPC. METHODS From 1993 to 1998, a population‐based cohort of 61,320 Singapore Chinese ages 45 years to 74 years who were free of cancer completed a comprehensive interview on living conditions and dietary and lifestyle factors. By linkage to Singapore population‐based registries, the cohort was followed through 2005, and cancer occurrence was determined. The relative risk of NPC and other oropharyngeal carcinomas in the cohort was investigated by using a Cox proportional hazards model. RESULTS In total, 173 NPCs and 75 other oropharyngeal carcinomas were observed during 601,879 person‐years of follow‐up. Smoking for >40 years was associated with a doubled risk of NPC (relative risk, 2.0; 95% confidence interval, 1.2–3.3), whereas smoking intensity, age at smoking initiation, and alcohol consumption were not associated with NPC risk. In contrast, smoking duration, smoking intensity, age at smoking initiation, and alcohol consumption all were associated with an increased risk of other oropharyngeal carcinoma ( P for trend, <.0001). CONCLUSIONS Smoking and alcohol influenced the risk of NPC and other oropharyngeal carcinomas differently in a high‐incidence NPC population. Long‐term smoking was a risk factor for NPC, but alcohol consumption was not. Cancer 2007. © 2007 American Cancer Society. Article in Journal/Newspaper Arctic Wiley Online Library Arctic Cancer 109 6 1183 1191 |
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Abstract BACKGROUND Nasopharyngeal carcinoma (NPC) is a rare disease in most populations; however, in areas of Southeast Asia and North Africa and in the Arctic, undifferentiated NPC is the most frequent pharyngeal malignancy. Although smoking and alcohol have been established firmly as synergistic risk factors for other pharyngeal carcinomas, previous studies on the association between these risk factors and NPC have not been consistent. Therefore, the authors analyzed this relation in a cohort of Singapore Chinese, which is a population with a high incidence of NPC. METHODS From 1993 to 1998, a population‐based cohort of 61,320 Singapore Chinese ages 45 years to 74 years who were free of cancer completed a comprehensive interview on living conditions and dietary and lifestyle factors. By linkage to Singapore population‐based registries, the cohort was followed through 2005, and cancer occurrence was determined. The relative risk of NPC and other oropharyngeal carcinomas in the cohort was investigated by using a Cox proportional hazards model. RESULTS In total, 173 NPCs and 75 other oropharyngeal carcinomas were observed during 601,879 person‐years of follow‐up. Smoking for >40 years was associated with a doubled risk of NPC (relative risk, 2.0; 95% confidence interval, 1.2–3.3), whereas smoking intensity, age at smoking initiation, and alcohol consumption were not associated with NPC risk. In contrast, smoking duration, smoking intensity, age at smoking initiation, and alcohol consumption all were associated with an increased risk of other oropharyngeal carcinoma ( P for trend, <.0001). CONCLUSIONS Smoking and alcohol influenced the risk of NPC and other oropharyngeal carcinomas differently in a high‐incidence NPC population. Long‐term smoking was a risk factor for NPC, but alcohol consumption was not. Cancer 2007. © 2007 American Cancer Society. |
format |
Article in Journal/Newspaper |
author |
Friborg, Jeppe T. Yuan, Jian‐Min Wang, Renwei Koh, Woon‐Puay Lee, Hin‐Peng Yu, Mimi C. |
spellingShingle |
Friborg, Jeppe T. Yuan, Jian‐Min Wang, Renwei Koh, Woon‐Puay Lee, Hin‐Peng Yu, Mimi C. A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese |
author_facet |
Friborg, Jeppe T. Yuan, Jian‐Min Wang, Renwei Koh, Woon‐Puay Lee, Hin‐Peng Yu, Mimi C. |
author_sort |
Friborg, Jeppe T. |
title |
A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese |
title_short |
A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese |
title_full |
A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese |
title_fullStr |
A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese |
title_full_unstemmed |
A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese |
title_sort |
prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in singapore chinese |
publisher |
Wiley |
publishDate |
2007 |
url |
http://dx.doi.org/10.1002/cncr.22501 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcncr.22501 https://onlinelibrary.wiley.com/doi/full/10.1002/cncr.22501 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Cancer volume 109, issue 6, page 1183-1191 ISSN 0008-543X 1097-0142 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/cncr.22501 |
container_title |
Cancer |
container_volume |
109 |
container_issue |
6 |
container_start_page |
1183 |
op_container_end_page |
1191 |
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1801373118333190144 |