Evaluation of the Enzymatic Reactive Distillation for the Production of Chiral Compounds

• Published in: Chemie Ingenieur Technik
• Main Authors: Wierschem, Matthias, Boll, Stefan, Lutze, Philip, Górak, Andrzej
• Other Authors: Ministry of Innovation, Science and Research of North Rhine-Westphalia
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2015
• Subjects: Antarc*; Antarctica
• Online Access: http://dx.doi.org/10.1002/cite.201500109; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcite.201500109; https://onlinelibrary.wiley.com/doi/pdf/10.1002/cite.201500109

Abstract In this work we investigated the feasibility of resolution and production of chiral compounds in an enzymatic reactive distillation column. Here, the transesterification of racemic 1‐phenylethanol with isopropenyl acetate was chosen as the model system. Enzyme kinetics with the enzymatic catalyst Candida antarctica lipase B immobilized on polymer beads were investigated experimentally. Based on those, a detailed model of enzymatic reactive distillation was developed and a subsequent model‐based process analysis showed the achievement of high conversion rates and a full separation of the reaction products.