Combining regio‐ and enantioselectivity of lipases for the preparation of ( R)‐4‐chloro‐2‐butanol

• Published in: Chirality
• Main Authors: Méndez, Jonh J., Oromi, Mireia, Cervero, Maria, Balcells, Mercè, Torres, Mercè, Canela, Ramon
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2006
• Subjects: Rugosa; Antarc*; Antarctica
• Online Access: http://dx.doi.org/10.1002/chir.20339; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchir.20339; https://onlinelibrary.wiley.com/doi/pdf/10.1002/chir.20339

Abstract Preparation of 98% ee ( R )‐4‐chloro‐2‐butanol was carried out by the enzymatic hydrolysis of chlorohydrin esters, using fungal resting cells and commercial enzymes. Hydrolyzes were carried out using lipases from Candida antarctica (Novozym 435®), C. rugosa, Rhizomucor miehei (Lipozyme® IM)...