Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine

Abstract Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac ‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine. Chirality 14:325–328, 2002. © 2002 Wiley‐Liss, I...

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Published in:Chirality
Main Authors: D'Antona, Nicola, Mangiafico, Sebastiano, Nicolosi, Giovanni
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2002
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1002/chir.10072
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spelling crwiley:10.1002/chir.10072 2024-06-02T07:57:03+00:00 Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine D'Antona, Nicola Mangiafico, Sebastiano Nicolosi, Giovanni 2002 http://dx.doi.org/10.1002/chir.10072 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchir.10072 https://onlinelibrary.wiley.com/doi/pdf/10.1002/chir.10072 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Chirality volume 14, issue 4, page 325-328 ISSN 0899-0042 1520-636X journal-article 2002 crwiley https://doi.org/10.1002/chir.10072 2024-05-03T11:50:16Z Abstract Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac ‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine. Chirality 14:325–328, 2002. © 2002 Wiley‐Liss, Inc. Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Chirality 14 4 325 328
institution Open Polar
collection Wiley Online Library
op_collection_id crwiley
language English
description Abstract Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac ‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine. Chirality 14:325–328, 2002. © 2002 Wiley‐Liss, Inc.
format Article in Journal/Newspaper
author D'Antona, Nicola
Mangiafico, Sebastiano
Nicolosi, Giovanni
spellingShingle D'Antona, Nicola
Mangiafico, Sebastiano
Nicolosi, Giovanni
Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine
author_facet D'Antona, Nicola
Mangiafico, Sebastiano
Nicolosi, Giovanni
author_sort D'Antona, Nicola
title Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine
title_short Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine
title_full Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine
title_fullStr Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine
title_full_unstemmed Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine
title_sort effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine
publisher Wiley
publishDate 2002
url http://dx.doi.org/10.1002/chir.10072
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchir.10072
https://onlinelibrary.wiley.com/doi/pdf/10.1002/chir.10072
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_source Chirality
volume 14, issue 4, page 325-328
ISSN 0899-0042 1520-636X
op_rights http://onlinelibrary.wiley.com/termsAndConditions#vor
op_doi https://doi.org/10.1002/chir.10072
container_title Chirality
container_volume 14
container_issue 4
container_start_page 325
op_container_end_page 328
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