Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine
Abstract Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac ‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine. Chirality 14:325–328, 2002. © 2002 Wiley‐Liss, I...
Published in: | Chirality |
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Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2002
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Subjects: | |
Online Access: | http://dx.doi.org/10.1002/chir.10072 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchir.10072 https://onlinelibrary.wiley.com/doi/pdf/10.1002/chir.10072 |
Summary: | Abstract Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac ‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine. Chirality 14:325–328, 2002. © 2002 Wiley‐Liss, Inc. |
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