Highly Chemoselective Catalytic Coupling of Substituted Oxetanes and Carbon Dioxide
Abstract The chemoselective coupling of oxetanes and carbon dioxide to afford functional, heterocyclic organic compounds known as six‐membered cyclic carbonates remains a challenging topic. Here, an effective method for their synthesis relying on the use of Al catalysis is described. The catalytic r...
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crwiley:10.1002/chem.201501576 2024-09-15T18:01:38+00:00 Highly Chemoselective Catalytic Coupling of Substituted Oxetanes and Carbon Dioxide Rintjema, Jeroen Guo, Wusheng Martin, Eddy Escudero‐Adán, Eduardo C. Kleij, Arjan W. 2015 http://dx.doi.org/10.1002/chem.201501576 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201501576 https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201501576 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Chemistry – A European Journal volume 21, issue 30, page 10754-10762 ISSN 0947-6539 1521-3765 journal-article 2015 crwiley https://doi.org/10.1002/chem.201501576 2024-08-22T04:16:57Z Abstract The chemoselective coupling of oxetanes and carbon dioxide to afford functional, heterocyclic organic compounds known as six‐membered cyclic carbonates remains a challenging topic. Here, an effective method for their synthesis relying on the use of Al catalysis is described. The catalytic reactions can be carried out with excellent selectivity for the cyclic carbonate product tolerating various (functional) groups present in the 2‐ and 3‐position(s) of the oxetane ring. The presented methodology is the first general approach towards the formation of six‐membered cyclic carbonates (6MCCs) through oxetane/CO 2 coupling chemistry. Apart from a series of substituted six‐membered cyclic carbonates, also the unprecedented room‐temperature coupling of oxetanes and CO 2 is disclosed giving, depending on the structural features of the substrate, a variety of five‐ and six‐membered heterocyclic products. A mechanistic rationale is presented for their formation and support for the intermediary presence of a carbonic acid derivative is given. The presented functional carbonates may hold great promise as building blocks in organic synthesis and the development of new, biodegradable polymers. Article in Journal/Newspaper Carbonic acid Wiley Online Library Chemistry – A European Journal 21 30 10754 10762 |
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Wiley Online Library |
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English |
description |
Abstract The chemoselective coupling of oxetanes and carbon dioxide to afford functional, heterocyclic organic compounds known as six‐membered cyclic carbonates remains a challenging topic. Here, an effective method for their synthesis relying on the use of Al catalysis is described. The catalytic reactions can be carried out with excellent selectivity for the cyclic carbonate product tolerating various (functional) groups present in the 2‐ and 3‐position(s) of the oxetane ring. The presented methodology is the first general approach towards the formation of six‐membered cyclic carbonates (6MCCs) through oxetane/CO 2 coupling chemistry. Apart from a series of substituted six‐membered cyclic carbonates, also the unprecedented room‐temperature coupling of oxetanes and CO 2 is disclosed giving, depending on the structural features of the substrate, a variety of five‐ and six‐membered heterocyclic products. A mechanistic rationale is presented for their formation and support for the intermediary presence of a carbonic acid derivative is given. The presented functional carbonates may hold great promise as building blocks in organic synthesis and the development of new, biodegradable polymers. |
format |
Article in Journal/Newspaper |
author |
Rintjema, Jeroen Guo, Wusheng Martin, Eddy Escudero‐Adán, Eduardo C. Kleij, Arjan W. |
spellingShingle |
Rintjema, Jeroen Guo, Wusheng Martin, Eddy Escudero‐Adán, Eduardo C. Kleij, Arjan W. Highly Chemoselective Catalytic Coupling of Substituted Oxetanes and Carbon Dioxide |
author_facet |
Rintjema, Jeroen Guo, Wusheng Martin, Eddy Escudero‐Adán, Eduardo C. Kleij, Arjan W. |
author_sort |
Rintjema, Jeroen |
title |
Highly Chemoselective Catalytic Coupling of Substituted Oxetanes and Carbon Dioxide |
title_short |
Highly Chemoselective Catalytic Coupling of Substituted Oxetanes and Carbon Dioxide |
title_full |
Highly Chemoselective Catalytic Coupling of Substituted Oxetanes and Carbon Dioxide |
title_fullStr |
Highly Chemoselective Catalytic Coupling of Substituted Oxetanes and Carbon Dioxide |
title_full_unstemmed |
Highly Chemoselective Catalytic Coupling of Substituted Oxetanes and Carbon Dioxide |
title_sort |
highly chemoselective catalytic coupling of substituted oxetanes and carbon dioxide |
publisher |
Wiley |
publishDate |
2015 |
url |
http://dx.doi.org/10.1002/chem.201501576 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201501576 https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201501576 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Chemistry – A European Journal volume 21, issue 30, page 10754-10762 ISSN 0947-6539 1521-3765 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/chem.201501576 |
container_title |
Chemistry – A European Journal |
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21 |
container_issue |
30 |
container_start_page |
10754 |
op_container_end_page |
10762 |
_version_ |
1810438747896938496 |