The First Direct Enzymatic Hydrolysis of Alicyclic β‐Amino Esters: A Route to Enantiopure cis and trans β‐Amino Acids
Abstract The first direct enzymatic method is reported for the synthesis of cis and trans β‐amino acid enantiomers through the lipase‐catalyzed enantioselective hydrolysis of alicyclic β‐amino esters in organic media. High enantioselectivities ( E usually >100) were observed when the Candida anta...
Published in: | Chemistry – A European Journal |
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Language: | English |
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Online Access: | http://dx.doi.org/10.1002/chem.200700257 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.200700257 https://onlinelibrary.wiley.com/doi/full/10.1002/chem.200700257 |
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crwiley:10.1002/chem.200700257 2024-06-23T07:47:49+00:00 The First Direct Enzymatic Hydrolysis of Alicyclic β‐Amino Esters: A Route to Enantiopure cis and trans β‐Amino Acids Forró, Enikõ Fülöp, Ferenc 2007 http://dx.doi.org/10.1002/chem.200700257 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.200700257 https://onlinelibrary.wiley.com/doi/full/10.1002/chem.200700257 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Chemistry – A European Journal volume 13, issue 22, page 6397-6401 ISSN 0947-6539 1521-3765 journal-article 2007 crwiley https://doi.org/10.1002/chem.200700257 2024-06-04T06:31:34Z Abstract The first direct enzymatic method is reported for the synthesis of cis and trans β‐amino acid enantiomers through the lipase‐catalyzed enantioselective hydrolysis of alicyclic β‐amino esters in organic media. High enantioselectivities ( E usually >100) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H 2 O (0.5 equivalents) in i Pr 2 O at 65 °C. The resolved products, obtained in good yields (≥42 %), could be easily separated. Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Chemistry – A European Journal 13 22 6397 6401 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract The first direct enzymatic method is reported for the synthesis of cis and trans β‐amino acid enantiomers through the lipase‐catalyzed enantioselective hydrolysis of alicyclic β‐amino esters in organic media. High enantioselectivities ( E usually >100) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H 2 O (0.5 equivalents) in i Pr 2 O at 65 °C. The resolved products, obtained in good yields (≥42 %), could be easily separated. |
format |
Article in Journal/Newspaper |
author |
Forró, Enikõ Fülöp, Ferenc |
spellingShingle |
Forró, Enikõ Fülöp, Ferenc The First Direct Enzymatic Hydrolysis of Alicyclic β‐Amino Esters: A Route to Enantiopure cis and trans β‐Amino Acids |
author_facet |
Forró, Enikõ Fülöp, Ferenc |
author_sort |
Forró, Enikõ |
title |
The First Direct Enzymatic Hydrolysis of Alicyclic β‐Amino Esters: A Route to Enantiopure cis and trans β‐Amino Acids |
title_short |
The First Direct Enzymatic Hydrolysis of Alicyclic β‐Amino Esters: A Route to Enantiopure cis and trans β‐Amino Acids |
title_full |
The First Direct Enzymatic Hydrolysis of Alicyclic β‐Amino Esters: A Route to Enantiopure cis and trans β‐Amino Acids |
title_fullStr |
The First Direct Enzymatic Hydrolysis of Alicyclic β‐Amino Esters: A Route to Enantiopure cis and trans β‐Amino Acids |
title_full_unstemmed |
The First Direct Enzymatic Hydrolysis of Alicyclic β‐Amino Esters: A Route to Enantiopure cis and trans β‐Amino Acids |
title_sort |
first direct enzymatic hydrolysis of alicyclic β‐amino esters: a route to enantiopure cis and trans β‐amino acids |
publisher |
Wiley |
publishDate |
2007 |
url |
http://dx.doi.org/10.1002/chem.200700257 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.200700257 https://onlinelibrary.wiley.com/doi/full/10.1002/chem.200700257 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Chemistry – A European Journal volume 13, issue 22, page 6397-6401 ISSN 0947-6539 1521-3765 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/chem.200700257 |
container_title |
Chemistry – A European Journal |
container_volume |
13 |
container_issue |
22 |
container_start_page |
6397 |
op_container_end_page |
6401 |
_version_ |
1802638005018558464 |