A Novel Tyrosine–Heme CO Covalent Linkage in F43Y Myoglobin: A New Post‐translational Modification of Heme Proteins
Abstract Heme post‐translational modification plays a key role in tuning the structure and function of heme proteins. We herein report a novel tyrosine–heme covalent CO bond in an artificially produced sperm whale myoglobin (Mb) mutant, F43Y Mb, which formed spontaneously in vivo between the Tyr43...
Published in: | ChemBioChem |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2014
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1002/cbic.201402504 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbic.201402504 https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.201402504 |
id |
crwiley:10.1002/cbic.201402504 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1002/cbic.201402504 2024-09-15T18:37:32+00:00 A Novel Tyrosine–Heme CO Covalent Linkage in F43Y Myoglobin: A New Post‐translational Modification of Heme Proteins Yan, Dao‐Jing Li, Wei Xiang, Yu Wen, Ge‐Bo Lin, Ying‐Wu Tan, Xiangshi 2014 http://dx.doi.org/10.1002/cbic.201402504 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbic.201402504 https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.201402504 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor ChemBioChem volume 16, issue 1, page 47-50 ISSN 1439-4227 1439-7633 journal-article 2014 crwiley https://doi.org/10.1002/cbic.201402504 2024-08-13T04:13:50Z Abstract Heme post‐translational modification plays a key role in tuning the structure and function of heme proteins. We herein report a novel tyrosine–heme covalent CO bond in an artificially produced sperm whale myoglobin (Mb) mutant, F43Y Mb, which formed spontaneously in vivo between the Tyr43 hydroxy group and the heme 4‐vinyl group. This highlights the diverse chemistry of heme post‐translational modifications, and lays groundwork for further investigation of the structural and functional diversity of covalently‐bound heme proteins. Article in Journal/Newspaper Sperm whale Wiley Online Library ChemBioChem 16 1 47 50 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Abstract Heme post‐translational modification plays a key role in tuning the structure and function of heme proteins. We herein report a novel tyrosine–heme covalent CO bond in an artificially produced sperm whale myoglobin (Mb) mutant, F43Y Mb, which formed spontaneously in vivo between the Tyr43 hydroxy group and the heme 4‐vinyl group. This highlights the diverse chemistry of heme post‐translational modifications, and lays groundwork for further investigation of the structural and functional diversity of covalently‐bound heme proteins. |
format |
Article in Journal/Newspaper |
author |
Yan, Dao‐Jing Li, Wei Xiang, Yu Wen, Ge‐Bo Lin, Ying‐Wu Tan, Xiangshi |
spellingShingle |
Yan, Dao‐Jing Li, Wei Xiang, Yu Wen, Ge‐Bo Lin, Ying‐Wu Tan, Xiangshi A Novel Tyrosine–Heme CO Covalent Linkage in F43Y Myoglobin: A New Post‐translational Modification of Heme Proteins |
author_facet |
Yan, Dao‐Jing Li, Wei Xiang, Yu Wen, Ge‐Bo Lin, Ying‐Wu Tan, Xiangshi |
author_sort |
Yan, Dao‐Jing |
title |
A Novel Tyrosine–Heme CO Covalent Linkage in F43Y Myoglobin: A New Post‐translational Modification of Heme Proteins |
title_short |
A Novel Tyrosine–Heme CO Covalent Linkage in F43Y Myoglobin: A New Post‐translational Modification of Heme Proteins |
title_full |
A Novel Tyrosine–Heme CO Covalent Linkage in F43Y Myoglobin: A New Post‐translational Modification of Heme Proteins |
title_fullStr |
A Novel Tyrosine–Heme CO Covalent Linkage in F43Y Myoglobin: A New Post‐translational Modification of Heme Proteins |
title_full_unstemmed |
A Novel Tyrosine–Heme CO Covalent Linkage in F43Y Myoglobin: A New Post‐translational Modification of Heme Proteins |
title_sort |
novel tyrosine–heme co covalent linkage in f43y myoglobin: a new post‐translational modification of heme proteins |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1002/cbic.201402504 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbic.201402504 https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.201402504 |
genre |
Sperm whale |
genre_facet |
Sperm whale |
op_source |
ChemBioChem volume 16, issue 1, page 47-50 ISSN 1439-4227 1439-7633 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/cbic.201402504 |
container_title |
ChemBioChem |
container_volume |
16 |
container_issue |
1 |
container_start_page |
47 |
op_container_end_page |
50 |
_version_ |
1810481917466771456 |