Synergistic Inhibitions of Gram‐Negative Bacteria by Combination Treatment with Ciprofloxacin and a Novel Glucolipid

• Published in: Chemistry & Biodiversity
• Main Authors: Yang, Liyuan, Zhang, Qingqing, Yu, Deng, Zhu, Weiming, Wang, Yi
• Other Authors: National Natural Science Foundation of China
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2024
• Subjects: Antarc*; Antarctica
• Online Access: http://dx.doi.org/10.1002/cbdv.202400578; https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202400578

Abstract Psychrophilic fungus Pseudogymnoascus sp. OUCMDZ‐4032 derived from Antarctica was cultivated under 16 °C to produce a new glucolipid compound ( 1 ). Its structure was elucidated by analysis of detailed spectroscopic data, acid hydrolysis and 1‐phenyl‐3‐methyl‐5‐pyrazolone precolumn derivatization, and 13 C NMR quantum chemical calculations. Though compound 1 did not show inhibitory activity against bacteria, it can reduce the minimum inhibitory concentration (MIC) of ciprofloxacin against Gram‐negative bacteria Pseudomonas aeruginosa , Escherichia coli , and Salmonella paratyphi by 1024, 256 and 256‐fold. Compound 1 showed potential as a synergistically inhibiting adjuvant in co‐administration with antibiotic to enhance antibacterial activities.