Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention
Abstract It is valuable to establish a population‐based prevaccination baseline distribution of human papillomavirus (HPV) types among women with high‐grade cervical intraepithelial neoplasia (CIN) grade 2 or 3 and cervical cancer in order to assess the potential impact of HPV vaccination. In four c...
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Online Access: | http://dx.doi.org/10.1002/cam4.1961 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcam4.1961 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.1961 |
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crwiley:10.1002/cam4.1961 2024-06-02T08:09:25+00:00 Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention Dovey de la Cour, Cecilie Guleria, Sonia Nygård, Mari Trygvadóttir, Laufey Sigurdsson, Kristjan Liaw, Kai‐Li Hortlund, Maria Lagheden, Camilla Hansen, Bo T. Munk, Christian Dillner, Joakim Kjaer, Susanne K. Merck 2019 http://dx.doi.org/10.1002/cam4.1961 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcam4.1961 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.1961 en eng Wiley http://creativecommons.org/licenses/by/4.0/ Cancer Medicine volume 8, issue 2, page 839-849 ISSN 2045-7634 2045-7634 journal-article 2019 crwiley https://doi.org/10.1002/cam4.1961 2024-05-06T06:59:41Z Abstract It is valuable to establish a population‐based prevaccination baseline distribution of human papillomavirus (HPV) types among women with high‐grade cervical intraepithelial neoplasia (CIN) grade 2 or 3 and cervical cancer in order to assess the potential impact of HPV vaccination. In four countries (Denmark, Norway, Sweden, and Iceland), we collected consecutive series of cervical cancers (n = 639) and high‐grade precancerous cervical lesions (n = 1240) during 2004‐2006 before implementation of HPV vaccination and subjected the specimens to standardized HPV genotyping. The HPV prevalence was 82.7% (95% confidence interval [CI] 79.0‐86.4) in CIN2, 91.6% (95% CI 89.7‐93.5) in CIN3, and 86.4% (95% CI 83.7‐89.1) in cervical cancer. The most common HPV types in CIN2/3 were HPV16 (CIN2: 35.9%, 95% CI 31.2‐40.6; CIN3: 50.2%, 95% CI 46.8‐53.6) and HPV31 (CIN2: 10.9%, 95% CI 7.8‐13.9; CIN3: 12.1%, 95% CI 9.9‐14.3), while HPV16 and HPV18 were the most frequent types in cervical cancer (48.8%, 95% CI 44.9‐52.7 and 15.3%, 95% CI 12.5‐18.1, respectively). The prevalence of HPV16/18 decreased with increasing age at diagnosis in both CIN2/3 and cervical cancer ( P < 0.0001). Elimination of HPV16/18 by vaccination is predicted to prevent 42% (95% CI 37.0‐46.7) of CIN2, 57% (95% CI 53.8‐60.5) of CIN3 and 64% (95% CI 60.3‐67.7) of cervical cancer. Prevention of the five additional HPV types HPV31/33/45/52/58 would increase the protection to 68% (95% CI 63.0‐72.2) in CIN2, 85% (95% CI 82.4‐87.2) in CIN3 and 80% (95% CI 77.0‐83.2) in cervical cancer. This study provides large‐scale and representative baselines for assessing and evaluating the population‐based preventive impact of HPV vaccination. Article in Journal/Newspaper Iceland Wiley Online Library Norway Cancer Medicine 8 2 839 849 |
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Abstract It is valuable to establish a population‐based prevaccination baseline distribution of human papillomavirus (HPV) types among women with high‐grade cervical intraepithelial neoplasia (CIN) grade 2 or 3 and cervical cancer in order to assess the potential impact of HPV vaccination. In four countries (Denmark, Norway, Sweden, and Iceland), we collected consecutive series of cervical cancers (n = 639) and high‐grade precancerous cervical lesions (n = 1240) during 2004‐2006 before implementation of HPV vaccination and subjected the specimens to standardized HPV genotyping. The HPV prevalence was 82.7% (95% confidence interval [CI] 79.0‐86.4) in CIN2, 91.6% (95% CI 89.7‐93.5) in CIN3, and 86.4% (95% CI 83.7‐89.1) in cervical cancer. The most common HPV types in CIN2/3 were HPV16 (CIN2: 35.9%, 95% CI 31.2‐40.6; CIN3: 50.2%, 95% CI 46.8‐53.6) and HPV31 (CIN2: 10.9%, 95% CI 7.8‐13.9; CIN3: 12.1%, 95% CI 9.9‐14.3), while HPV16 and HPV18 were the most frequent types in cervical cancer (48.8%, 95% CI 44.9‐52.7 and 15.3%, 95% CI 12.5‐18.1, respectively). The prevalence of HPV16/18 decreased with increasing age at diagnosis in both CIN2/3 and cervical cancer ( P < 0.0001). Elimination of HPV16/18 by vaccination is predicted to prevent 42% (95% CI 37.0‐46.7) of CIN2, 57% (95% CI 53.8‐60.5) of CIN3 and 64% (95% CI 60.3‐67.7) of cervical cancer. Prevention of the five additional HPV types HPV31/33/45/52/58 would increase the protection to 68% (95% CI 63.0‐72.2) in CIN2, 85% (95% CI 82.4‐87.2) in CIN3 and 80% (95% CI 77.0‐83.2) in cervical cancer. This study provides large‐scale and representative baselines for assessing and evaluating the population‐based preventive impact of HPV vaccination. |
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Merck |
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Article in Journal/Newspaper |
author |
Dovey de la Cour, Cecilie Guleria, Sonia Nygård, Mari Trygvadóttir, Laufey Sigurdsson, Kristjan Liaw, Kai‐Li Hortlund, Maria Lagheden, Camilla Hansen, Bo T. Munk, Christian Dillner, Joakim Kjaer, Susanne K. |
spellingShingle |
Dovey de la Cour, Cecilie Guleria, Sonia Nygård, Mari Trygvadóttir, Laufey Sigurdsson, Kristjan Liaw, Kai‐Li Hortlund, Maria Lagheden, Camilla Hansen, Bo T. Munk, Christian Dillner, Joakim Kjaer, Susanne K. Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
author_facet |
Dovey de la Cour, Cecilie Guleria, Sonia Nygård, Mari Trygvadóttir, Laufey Sigurdsson, Kristjan Liaw, Kai‐Li Hortlund, Maria Lagheden, Camilla Hansen, Bo T. Munk, Christian Dillner, Joakim Kjaer, Susanne K. |
author_sort |
Dovey de la Cour, Cecilie |
title |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_short |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_full |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_fullStr |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_full_unstemmed |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_sort |
human papillomavirus types in cervical high‐grade lesions or cancer among nordic women—potential for prevention |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1002/cam4.1961 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcam4.1961 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.1961 |
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Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Cancer Medicine volume 8, issue 2, page 839-849 ISSN 2045-7634 2045-7634 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1002/cam4.1961 |
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Cancer Medicine |
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8 |
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2 |
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839 |
op_container_end_page |
849 |
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1800755140882333696 |