High serum coenzyme Q 10 , positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study
Abstract Greenlanders (Eskimos) have low prevalence of ischaemic heart disease, partly explained by a lower extent of atherosclerosis and a low n‐6/n‐3 ratio of polyunsaturated fatty acids. As atherosclerosis is also a result of oxidative stress, the total antioxidative readiness could have a substa...
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crwiley:10.1002/biof.5520090230 2024-06-02T08:06:07+00:00 High serum coenzyme Q 10 , positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study Pedersen, H. S. Mortensen, S. A. Rohde, M. Deguchi, Y. Mulvad, G. Bjerregaard, P. Hansen, J. C. 1999 http://dx.doi.org/10.1002/biof.5520090230 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiof.5520090230 https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1002/biof.5520090230 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor BioFactors volume 9, issue 2-4, page 319-323 ISSN 0951-6433 1872-8081 journal-article 1999 crwiley https://doi.org/10.1002/biof.5520090230 2024-05-03T11:32:41Z Abstract Greenlanders (Eskimos) have low prevalence of ischaemic heart disease, partly explained by a lower extent of atherosclerosis and a low n‐6/n‐3 ratio of polyunsaturated fatty acids. As atherosclerosis is also a result of oxidative stress, the total antioxidative readiness could have a substantial impact. From a health survey we chose the subpopulation from the most remote area, where the traditional Greenlandic diet with high intake of sea mammals and fish predominates. The mean (SD) of S‐CoQ 10 in males was 1.495 (0.529) nmol/ml and 1.421 (0.629) nmol/ml in females, significantly higher (p<0.001) compared to a Danish population. In a linear multiple regression model the S‐CoQ 10 level is significantly positively associated with age and S‐selenium in males, and S‐total cholesterol in females. The high level of CoQ 10 in Greenlanders probably reflects diet, since no bioaccumulation takes place, and it could probably be a substantial part of the antioxidative defense. Article in Journal/Newspaper eskimo* Greenland greenlander* greenlandic inuit Wiley Online Library Greenland BioFactors 9 2-4 319 323 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract Greenlanders (Eskimos) have low prevalence of ischaemic heart disease, partly explained by a lower extent of atherosclerosis and a low n‐6/n‐3 ratio of polyunsaturated fatty acids. As atherosclerosis is also a result of oxidative stress, the total antioxidative readiness could have a substantial impact. From a health survey we chose the subpopulation from the most remote area, where the traditional Greenlandic diet with high intake of sea mammals and fish predominates. The mean (SD) of S‐CoQ 10 in males was 1.495 (0.529) nmol/ml and 1.421 (0.629) nmol/ml in females, significantly higher (p<0.001) compared to a Danish population. In a linear multiple regression model the S‐CoQ 10 level is significantly positively associated with age and S‐selenium in males, and S‐total cholesterol in females. The high level of CoQ 10 in Greenlanders probably reflects diet, since no bioaccumulation takes place, and it could probably be a substantial part of the antioxidative defense. |
format |
Article in Journal/Newspaper |
author |
Pedersen, H. S. Mortensen, S. A. Rohde, M. Deguchi, Y. Mulvad, G. Bjerregaard, P. Hansen, J. C. |
spellingShingle |
Pedersen, H. S. Mortensen, S. A. Rohde, M. Deguchi, Y. Mulvad, G. Bjerregaard, P. Hansen, J. C. High serum coenzyme Q 10 , positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study |
author_facet |
Pedersen, H. S. Mortensen, S. A. Rohde, M. Deguchi, Y. Mulvad, G. Bjerregaard, P. Hansen, J. C. |
author_sort |
Pedersen, H. S. |
title |
High serum coenzyme Q 10 , positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study |
title_short |
High serum coenzyme Q 10 , positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study |
title_full |
High serum coenzyme Q 10 , positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study |
title_fullStr |
High serum coenzyme Q 10 , positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study |
title_full_unstemmed |
High serum coenzyme Q 10 , positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study |
title_sort |
high serum coenzyme q 10 , positively correlated with age, selenium and cholesterol, in inuit of greenland. a pilot study |
publisher |
Wiley |
publishDate |
1999 |
url |
http://dx.doi.org/10.1002/biof.5520090230 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiof.5520090230 https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1002/biof.5520090230 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland greenlander* greenlandic inuit |
genre_facet |
eskimo* Greenland greenlander* greenlandic inuit |
op_source |
BioFactors volume 9, issue 2-4, page 319-323 ISSN 0951-6433 1872-8081 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/biof.5520090230 |
container_title |
BioFactors |
container_volume |
9 |
container_issue |
2-4 |
container_start_page |
319 |
op_container_end_page |
323 |
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1800751016646279168 |