Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource
Objective The level of cartilage acidic protein 1 (CRTAC1) in plasma was recently discovered to be associated with osteoarthritis (OA) risk and progression to joint replacement in Iceland. This study was undertaken to validate these findings in an independent population. Methods In this study, 1,462...
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crwiley:10.1002/art.42376 2024-10-13T14:08:32+00:00 Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource Styrkarsdottir, Unnur Lund, Sigrun H. Thorleifsson, Gudmar Saevarsdottir, Saedis Gudbjartsson, Daniel F. Thorsteinsdottir, Unnur Stefansson, Kari Amgen Inc. 2022 http://dx.doi.org/10.1002/art.42376 https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.42376 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/art.42376 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ Arthritis & Rheumatology volume 75, issue 4, page 544-552 ISSN 2326-5191 2326-5205 journal-article 2022 crwiley https://doi.org/10.1002/art.42376 2024-09-23T04:37:03Z Objective The level of cartilage acidic protein 1 (CRTAC1) in plasma was recently discovered to be associated with osteoarthritis (OA) risk and progression to joint replacement in Iceland. This study was undertaken to validate these findings in an independent population. Methods In this study, 1,462 plasma proteins were measured in 54,265 participants from the UK Biobank on the Olink Explore platform. We analyzed the association of plasma proteins with prevalent OA, incident OA, and progression to joint replacement. We assessed the specificity of OA association through comparison of associations with inflammatory joint diseases and with previous joint replacement. Results The CRTAC1 protein showed the strongest association with prevalent knee OA (odds ratio [OR] 1.34 [95% confidence interval (95% CI) 1.27, 1.41]) and was associated with hip OA (OR 1.19 [95% CI 1.11, 1.28]). It predicted incident diagnosis of OA in the knee (hazard ratio [HR] 1.40 [95% CI 1.35, 1.46]) and hip (HR 1.25 [95% CI 1.19, 1.31]), as well as progression to joint replacement (HR 1.20 [95% CI 1.08, 1.33] for the knee and HR 1.22 [95% CI 1.08, 1.38] for the hip), while no association was found with inflammatory joint diseases. Individuals in the highest quintile of risk based on CRTAC1 level, age, sex, and body mass index had a 10‐fold risk of knee or hip OA within 5 years compared to those in the lowest quintile. Adding aggrecan core protein (ACAN) and neurocan core protein (NCAN) to the model improved the prediction of OA but not joint replacement. Furthermore, we replicated the association of CUB domain–containing protein 1 with prior joint replacement. Conclusion Plasma CRTAC1 is a specific biomarker for OA and a predictor of OA risk and progression to joint replacement. Adding ACAN and NCAN protein levels to the CRTAC1 model improved the prediction of OA. Article in Journal/Newspaper Iceland Wiley Online Library Arthritis & Rheumatology 75 4 544 552 |
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Objective The level of cartilage acidic protein 1 (CRTAC1) in plasma was recently discovered to be associated with osteoarthritis (OA) risk and progression to joint replacement in Iceland. This study was undertaken to validate these findings in an independent population. Methods In this study, 1,462 plasma proteins were measured in 54,265 participants from the UK Biobank on the Olink Explore platform. We analyzed the association of plasma proteins with prevalent OA, incident OA, and progression to joint replacement. We assessed the specificity of OA association through comparison of associations with inflammatory joint diseases and with previous joint replacement. Results The CRTAC1 protein showed the strongest association with prevalent knee OA (odds ratio [OR] 1.34 [95% confidence interval (95% CI) 1.27, 1.41]) and was associated with hip OA (OR 1.19 [95% CI 1.11, 1.28]). It predicted incident diagnosis of OA in the knee (hazard ratio [HR] 1.40 [95% CI 1.35, 1.46]) and hip (HR 1.25 [95% CI 1.19, 1.31]), as well as progression to joint replacement (HR 1.20 [95% CI 1.08, 1.33] for the knee and HR 1.22 [95% CI 1.08, 1.38] for the hip), while no association was found with inflammatory joint diseases. Individuals in the highest quintile of risk based on CRTAC1 level, age, sex, and body mass index had a 10‐fold risk of knee or hip OA within 5 years compared to those in the lowest quintile. Adding aggrecan core protein (ACAN) and neurocan core protein (NCAN) to the model improved the prediction of OA but not joint replacement. Furthermore, we replicated the association of CUB domain–containing protein 1 with prior joint replacement. Conclusion Plasma CRTAC1 is a specific biomarker for OA and a predictor of OA risk and progression to joint replacement. Adding ACAN and NCAN protein levels to the CRTAC1 model improved the prediction of OA. |
author2 |
Amgen Inc. |
format |
Article in Journal/Newspaper |
author |
Styrkarsdottir, Unnur Lund, Sigrun H. Thorleifsson, Gudmar Saevarsdottir, Saedis Gudbjartsson, Daniel F. Thorsteinsdottir, Unnur Stefansson, Kari |
spellingShingle |
Styrkarsdottir, Unnur Lund, Sigrun H. Thorleifsson, Gudmar Saevarsdottir, Saedis Gudbjartsson, Daniel F. Thorsteinsdottir, Unnur Stefansson, Kari Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource |
author_facet |
Styrkarsdottir, Unnur Lund, Sigrun H. Thorleifsson, Gudmar Saevarsdottir, Saedis Gudbjartsson, Daniel F. Thorsteinsdottir, Unnur Stefansson, Kari |
author_sort |
Styrkarsdottir, Unnur |
title |
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource |
title_short |
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource |
title_full |
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource |
title_fullStr |
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource |
title_full_unstemmed |
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource |
title_sort |
cartilage acidic protein 1 in plasma associates with prevalent osteoarthritis and predicts future risk as well as progression to joint replacements: results from the uk biobank resource |
publisher |
Wiley |
publishDate |
2022 |
url |
http://dx.doi.org/10.1002/art.42376 https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.42376 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/art.42376 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Arthritis & Rheumatology volume 75, issue 4, page 544-552 ISSN 2326-5191 2326-5205 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1002/art.42376 |
container_title |
Arthritis & Rheumatology |
container_volume |
75 |
container_issue |
4 |
container_start_page |
544 |
op_container_end_page |
552 |
_version_ |
1812815219951403008 |