Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
Abstract Objective To evaluate the prevalence and predictive value of anti–cyclic citrullinated peptide (anti‐CCP) antibodies in individuals who subsequently developed rheumatoid arthritis (RA) and to determine the relationship to rheumatoid factor (RF) of any isotype. Methods A case–control study w...
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crwiley:10.1002/art.11223 2024-06-23T07:55:36+00:00 Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis Rantapää‐Dahlqvist, Solbritt de Jong, Ben A. W. Berglin, Ewa Hallmans, Göran Wadell, Göran Stenlund, Hans Sundin, Ulf van Venrooij, Walther J. King Gustaf V's 80-Year Fund Swedish Rheumatism Association Medical Faculty of Umea University, Umea, Sweden The Netherlands Organization for Scientific Research in the Medical Sciences Dutch League Against Rheumatism Council for Chemical Sciences The Netherlands Technology Foundation 2003 http://dx.doi.org/10.1002/art.11223 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fart.11223 https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.11223 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Arthritis & Rheumatism volume 48, issue 10, page 2741-2749 ISSN 0004-3591 1529-0131 journal-article 2003 crwiley https://doi.org/10.1002/art.11223 2024-06-13T04:21:01Z Abstract Objective To evaluate the prevalence and predictive value of anti–cyclic citrullinated peptide (anti‐CCP) antibodies in individuals who subsequently developed rheumatoid arthritis (RA) and to determine the relationship to rheumatoid factor (RF) of any isotype. Methods A case–control study was nested within the Northern Sweden Health and Disease Study and the Maternity cohorts of Northern Sweden. Patients with RA were identified among blood donors whose samples had been taken years before the onset of symptoms. Control subjects matched for age, sex, date of sampling, and residential area were selected randomly from the same cohorts. Anti‐CCP antibody and RFs were determined using enzyme immunoassays. Results Eighty‐three individuals with RA were identified as having donated blood before presenting with any symptoms of joint disease (median 2.5 years [interquartile range 1.1–4.7] before RA). In samples obtained before the onset of RA, the prevalence of autoantibodies was 33.7% for anti‐CCP, 16.9% for IgG‐RF, 19.3% for IgM‐RF, and 33.7% for IgA‐RF (all highly significant compared with controls). The sensitivities for detecting these autoantibodies >1.5 years and ≤1.5 years before the appearance of any RA symptoms were 25% and 52% for anti‐CCP, 15% and 30% for IgM‐RF, 12% and 27% for IgG‐RF, and 29% and 39% for IgA‐RF. In conditional logistic regression models, anti‐CCP antibody and IgA‐RF were found to be significant predictors of RA. Conclusion Anti‐CCP antibody and RFs of all isotypes predated the onset of RA by several years. The presence of anti‐CCP and IgA‐RF predicted the development of RA, with anti‐CCP antibody having the highest predictive value. This indicates that citrullination and the production of anti‐CCP and RF autoantibodies are early processes in RA. Article in Journal/Newspaper Northern Sweden Wiley Online Library Arthritis & Rheumatism 48 10 2741 2749 |
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Abstract Objective To evaluate the prevalence and predictive value of anti–cyclic citrullinated peptide (anti‐CCP) antibodies in individuals who subsequently developed rheumatoid arthritis (RA) and to determine the relationship to rheumatoid factor (RF) of any isotype. Methods A case–control study was nested within the Northern Sweden Health and Disease Study and the Maternity cohorts of Northern Sweden. Patients with RA were identified among blood donors whose samples had been taken years before the onset of symptoms. Control subjects matched for age, sex, date of sampling, and residential area were selected randomly from the same cohorts. Anti‐CCP antibody and RFs were determined using enzyme immunoassays. Results Eighty‐three individuals with RA were identified as having donated blood before presenting with any symptoms of joint disease (median 2.5 years [interquartile range 1.1–4.7] before RA). In samples obtained before the onset of RA, the prevalence of autoantibodies was 33.7% for anti‐CCP, 16.9% for IgG‐RF, 19.3% for IgM‐RF, and 33.7% for IgA‐RF (all highly significant compared with controls). The sensitivities for detecting these autoantibodies >1.5 years and ≤1.5 years before the appearance of any RA symptoms were 25% and 52% for anti‐CCP, 15% and 30% for IgM‐RF, 12% and 27% for IgG‐RF, and 29% and 39% for IgA‐RF. In conditional logistic regression models, anti‐CCP antibody and IgA‐RF were found to be significant predictors of RA. Conclusion Anti‐CCP antibody and RFs of all isotypes predated the onset of RA by several years. The presence of anti‐CCP and IgA‐RF predicted the development of RA, with anti‐CCP antibody having the highest predictive value. This indicates that citrullination and the production of anti‐CCP and RF autoantibodies are early processes in RA. |
author2 |
King Gustaf V's 80-Year Fund Swedish Rheumatism Association Medical Faculty of Umea University, Umea, Sweden The Netherlands Organization for Scientific Research in the Medical Sciences Dutch League Against Rheumatism Council for Chemical Sciences The Netherlands Technology Foundation |
format |
Article in Journal/Newspaper |
author |
Rantapää‐Dahlqvist, Solbritt de Jong, Ben A. W. Berglin, Ewa Hallmans, Göran Wadell, Göran Stenlund, Hans Sundin, Ulf van Venrooij, Walther J. |
spellingShingle |
Rantapää‐Dahlqvist, Solbritt de Jong, Ben A. W. Berglin, Ewa Hallmans, Göran Wadell, Göran Stenlund, Hans Sundin, Ulf van Venrooij, Walther J. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis |
author_facet |
Rantapää‐Dahlqvist, Solbritt de Jong, Ben A. W. Berglin, Ewa Hallmans, Göran Wadell, Göran Stenlund, Hans Sundin, Ulf van Venrooij, Walther J. |
author_sort |
Rantapää‐Dahlqvist, Solbritt |
title |
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis |
title_short |
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis |
title_full |
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis |
title_fullStr |
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis |
title_full_unstemmed |
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis |
title_sort |
antibodies against cyclic citrullinated peptide and iga rheumatoid factor predict the development of rheumatoid arthritis |
publisher |
Wiley |
publishDate |
2003 |
url |
http://dx.doi.org/10.1002/art.11223 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fart.11223 https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.11223 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Arthritis & Rheumatism volume 48, issue 10, page 2741-2749 ISSN 0004-3591 1529-0131 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/art.11223 |
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Arthritis & Rheumatism |
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48 |
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10 |
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2741 |
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2749 |
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1802648259378806784 |