Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators
Abstract We performed a systematic characterization of the hepatic vitamin A storage in mammals and birds of the Svalbard archipelago and Greenland. The liver of top predators, including polar bear, arctic fox, bearded seal, and glaucous gull, contained about 10–20 times more vitamin A than the live...
Published in: | The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology |
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Online Access: | http://dx.doi.org/10.1002/ar.22555 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Far.22555 https://onlinelibrary.wiley.com/doi/full/10.1002/ar.22555 |
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crwiley:10.1002/ar.22555 2024-06-23T07:48:59+00:00 Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators Senoo, Haruki Imai, Katsuyuki Mezaki, Yoshihiro Miura, Mitsutaka Morii, Mayako Fujiwara, Mutsunori Blomhoff, Rune 2012 http://dx.doi.org/10.1002/ar.22555 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Far.22555 https://onlinelibrary.wiley.com/doi/full/10.1002/ar.22555 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor The Anatomical Record volume 295, issue 10, page 1660-1668 ISSN 1932-8486 1932-8494 journal-article 2012 crwiley https://doi.org/10.1002/ar.22555 2024-06-13T04:22:58Z Abstract We performed a systematic characterization of the hepatic vitamin A storage in mammals and birds of the Svalbard archipelago and Greenland. The liver of top predators, including polar bear, arctic fox, bearded seal, and glaucous gull, contained about 10–20 times more vitamin A than the liver of all other arctic animals studied, as well as their genetically related continental top predators. The values are also high compared to normal human and experimental animals like mouse and rat. This massive amount of hepatic vitamin A was located in large autofluorescent lipid droplets in hepatic stellate cells (HSCs; also called vitamin A‐storing cells, lipocytes, interstitial cells, fat‐storing cells, or Ito cells). The droplets made up most of the cells' cytoplasm. The development of such an efficient vitamin A‐storing mechanism in HSCs may have contributed to the survival of top predators in the extreme environment of the arctic. These animals demonstrated no signs of hypervitaminosis A. We suggest that HSCs have capacity to take‐up and store large amounts of vitamin A, which may play a pivotal role in maintenance of the food web, food chain, biodiversity, and eventually ecology of the arctic. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc. Article in Journal/Newspaper Arctic Fox Arctic bearded seal Glaucous Gull Greenland polar bear Svalbard Wiley Online Library Arctic Greenland Svalbard Svalbard Archipelago The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 295 10 1660 1668 |
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Open Polar |
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Wiley Online Library |
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crwiley |
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English |
description |
Abstract We performed a systematic characterization of the hepatic vitamin A storage in mammals and birds of the Svalbard archipelago and Greenland. The liver of top predators, including polar bear, arctic fox, bearded seal, and glaucous gull, contained about 10–20 times more vitamin A than the liver of all other arctic animals studied, as well as their genetically related continental top predators. The values are also high compared to normal human and experimental animals like mouse and rat. This massive amount of hepatic vitamin A was located in large autofluorescent lipid droplets in hepatic stellate cells (HSCs; also called vitamin A‐storing cells, lipocytes, interstitial cells, fat‐storing cells, or Ito cells). The droplets made up most of the cells' cytoplasm. The development of such an efficient vitamin A‐storing mechanism in HSCs may have contributed to the survival of top predators in the extreme environment of the arctic. These animals demonstrated no signs of hypervitaminosis A. We suggest that HSCs have capacity to take‐up and store large amounts of vitamin A, which may play a pivotal role in maintenance of the food web, food chain, biodiversity, and eventually ecology of the arctic. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc. |
format |
Article in Journal/Newspaper |
author |
Senoo, Haruki Imai, Katsuyuki Mezaki, Yoshihiro Miura, Mitsutaka Morii, Mayako Fujiwara, Mutsunori Blomhoff, Rune |
spellingShingle |
Senoo, Haruki Imai, Katsuyuki Mezaki, Yoshihiro Miura, Mitsutaka Morii, Mayako Fujiwara, Mutsunori Blomhoff, Rune Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators |
author_facet |
Senoo, Haruki Imai, Katsuyuki Mezaki, Yoshihiro Miura, Mitsutaka Morii, Mayako Fujiwara, Mutsunori Blomhoff, Rune |
author_sort |
Senoo, Haruki |
title |
Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators |
title_short |
Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators |
title_full |
Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators |
title_fullStr |
Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators |
title_full_unstemmed |
Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators |
title_sort |
accumulation of vitamin a in the hepatic stellate cell of arctic top predators |
publisher |
Wiley |
publishDate |
2012 |
url |
http://dx.doi.org/10.1002/ar.22555 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Far.22555 https://onlinelibrary.wiley.com/doi/full/10.1002/ar.22555 |
geographic |
Arctic Greenland Svalbard Svalbard Archipelago |
geographic_facet |
Arctic Greenland Svalbard Svalbard Archipelago |
genre |
Arctic Fox Arctic bearded seal Glaucous Gull Greenland polar bear Svalbard |
genre_facet |
Arctic Fox Arctic bearded seal Glaucous Gull Greenland polar bear Svalbard |
op_source |
The Anatomical Record volume 295, issue 10, page 1660-1668 ISSN 1932-8486 1932-8494 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ar.22555 |
container_title |
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology |
container_volume |
295 |
container_issue |
10 |
container_start_page |
1660 |
op_container_end_page |
1668 |
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1802639274525327360 |