Catalytic Reductive N‐Alkylations Using CO 2 and Carboxylic Acid Derivatives: Recent Progress and Developments
Abstract N‐Alkylamines are key intermediates in the synthesis of fine chemicals, dyes, and natural products, and hence are highly valuable building blocks in organic chemistry. Consequently, the development of greener and more efficient procedures for their production continues to attract the intere...
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crwiley:10.1002/anie.201810121 2024-06-23T07:52:03+00:00 Catalytic Reductive N‐Alkylations Using CO 2 and Carboxylic Acid Derivatives: Recent Progress and Developments Cabrero‐Antonino, Jose R. Adam, Rosa Beller, Matthias 2019 http://dx.doi.org/10.1002/anie.201810121 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201810121 https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201810121 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.201810121 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Angewandte Chemie International Edition volume 58, issue 37, page 12820-12838 ISSN 1433-7851 1521-3773 journal-article 2019 crwiley https://doi.org/10.1002/anie.201810121 2024-06-13T04:25:09Z Abstract N‐Alkylamines are key intermediates in the synthesis of fine chemicals, dyes, and natural products, and hence are highly valuable building blocks in organic chemistry. Consequently, the development of greener and more efficient procedures for their production continues to attract the interest of both academic and industrial chemists. Reductive procedures such as reductive amination or N‐alkylation through hydrogen autotransfer by employing carbonyl compounds or alcohols as alkylating agents have prevailed for the synthesis of amines. In the last few years, carboxylic/carbonic acid derivatives and CO 2 have been introduced as alternative and convenient alkylating sources. The safety, easy accessibility, and high stability of these reagents makes the development of new reductive transformations with them as N‐alkylating agents a useful alternative to existing procedures. In this Review, we summarize reported examples of one‐pot reductive N‐alkylation methods that use carboxylic/carbonic acid derivatives or CO 2 as alkylating agents. Article in Journal/Newspaper Carbonic acid Wiley Online Library Angewandte Chemie International Edition 58 37 12820 12838 |
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Wiley Online Library |
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crwiley |
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English |
description |
Abstract N‐Alkylamines are key intermediates in the synthesis of fine chemicals, dyes, and natural products, and hence are highly valuable building blocks in organic chemistry. Consequently, the development of greener and more efficient procedures for their production continues to attract the interest of both academic and industrial chemists. Reductive procedures such as reductive amination or N‐alkylation through hydrogen autotransfer by employing carbonyl compounds or alcohols as alkylating agents have prevailed for the synthesis of amines. In the last few years, carboxylic/carbonic acid derivatives and CO 2 have been introduced as alternative and convenient alkylating sources. The safety, easy accessibility, and high stability of these reagents makes the development of new reductive transformations with them as N‐alkylating agents a useful alternative to existing procedures. In this Review, we summarize reported examples of one‐pot reductive N‐alkylation methods that use carboxylic/carbonic acid derivatives or CO 2 as alkylating agents. |
format |
Article in Journal/Newspaper |
author |
Cabrero‐Antonino, Jose R. Adam, Rosa Beller, Matthias |
spellingShingle |
Cabrero‐Antonino, Jose R. Adam, Rosa Beller, Matthias Catalytic Reductive N‐Alkylations Using CO 2 and Carboxylic Acid Derivatives: Recent Progress and Developments |
author_facet |
Cabrero‐Antonino, Jose R. Adam, Rosa Beller, Matthias |
author_sort |
Cabrero‐Antonino, Jose R. |
title |
Catalytic Reductive N‐Alkylations Using CO 2 and Carboxylic Acid Derivatives: Recent Progress and Developments |
title_short |
Catalytic Reductive N‐Alkylations Using CO 2 and Carboxylic Acid Derivatives: Recent Progress and Developments |
title_full |
Catalytic Reductive N‐Alkylations Using CO 2 and Carboxylic Acid Derivatives: Recent Progress and Developments |
title_fullStr |
Catalytic Reductive N‐Alkylations Using CO 2 and Carboxylic Acid Derivatives: Recent Progress and Developments |
title_full_unstemmed |
Catalytic Reductive N‐Alkylations Using CO 2 and Carboxylic Acid Derivatives: Recent Progress and Developments |
title_sort |
catalytic reductive n‐alkylations using co 2 and carboxylic acid derivatives: recent progress and developments |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1002/anie.201810121 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201810121 https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201810121 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.201810121 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Angewandte Chemie International Edition volume 58, issue 37, page 12820-12838 ISSN 1433-7851 1521-3773 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/anie.201810121 |
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Angewandte Chemie International Edition |
container_volume |
58 |
container_issue |
37 |
container_start_page |
12820 |
op_container_end_page |
12838 |
_version_ |
1802643241591373824 |