Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum
Abstract Exposure of polar bears ( Ursus maritimus ) to persistent organic pollutants was discovered in the 1970s, but recent evidence suggests the presence of unknown toxic chemicals in their blood. Protein and phospholipid depleted serum was stirred with polyethersulfone capillaries to extract a b...
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crwiley:10.1002/anie.201809906 2024-09-15T17:58:38+00:00 Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum Liu, Yanna Richardson, Evan S. Derocher, Andrew E. Lunn, Nicholas J. Lehmler, Hans‐Joachim Li, Xueshu Zhang, Yifeng Cui, Julia Yue Cheng, Lihua Martin, Jonathan W. Natural Sciences and Engineering Research Council of Canada Foundation for the National Institutes of Health 2018 http://dx.doi.org/10.1002/anie.201809906 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201809906 https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201809906 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Angewandte Chemie International Edition volume 57, issue 50, page 16401-16406 ISSN 1433-7851 1521-3773 journal-article 2018 crwiley https://doi.org/10.1002/anie.201809906 2024-09-05T05:07:10Z Abstract Exposure of polar bears ( Ursus maritimus ) to persistent organic pollutants was discovered in the 1970s, but recent evidence suggests the presence of unknown toxic chemicals in their blood. Protein and phospholipid depleted serum was stirred with polyethersulfone capillaries to extract a broad range of analytes, and nontarget mass spectrometry with “fragmentation flagging” was used for detection. Hundreds of analytes were discovered belonging to 13 classes, including novel polychlorinated biphenyl (PCB) metabolites and many fluorinated or chlorinated substances not previously detected. All analytes were detected in the oldest (mid‐1980s) archived polar bear serum from Hudson Bay and Beaufort Sea, and all fluorinated classes showed increasing trends. A mouse experiment confirmed the novel PCB metabolites, suggesting that these could be widespread in mammals. Historical exposure and toxic risk has been underestimated, and these halogenated contaminants pose uncertain risks to this threatened species. Article in Journal/Newspaper Beaufort Sea Hudson Bay Ursus maritimus Wiley Online Library Angewandte Chemie International Edition 57 50 16401 16406 |
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Wiley Online Library |
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English |
description |
Abstract Exposure of polar bears ( Ursus maritimus ) to persistent organic pollutants was discovered in the 1970s, but recent evidence suggests the presence of unknown toxic chemicals in their blood. Protein and phospholipid depleted serum was stirred with polyethersulfone capillaries to extract a broad range of analytes, and nontarget mass spectrometry with “fragmentation flagging” was used for detection. Hundreds of analytes were discovered belonging to 13 classes, including novel polychlorinated biphenyl (PCB) metabolites and many fluorinated or chlorinated substances not previously detected. All analytes were detected in the oldest (mid‐1980s) archived polar bear serum from Hudson Bay and Beaufort Sea, and all fluorinated classes showed increasing trends. A mouse experiment confirmed the novel PCB metabolites, suggesting that these could be widespread in mammals. Historical exposure and toxic risk has been underestimated, and these halogenated contaminants pose uncertain risks to this threatened species. |
author2 |
Natural Sciences and Engineering Research Council of Canada Foundation for the National Institutes of Health |
format |
Article in Journal/Newspaper |
author |
Liu, Yanna Richardson, Evan S. Derocher, Andrew E. Lunn, Nicholas J. Lehmler, Hans‐Joachim Li, Xueshu Zhang, Yifeng Cui, Julia Yue Cheng, Lihua Martin, Jonathan W. |
spellingShingle |
Liu, Yanna Richardson, Evan S. Derocher, Andrew E. Lunn, Nicholas J. Lehmler, Hans‐Joachim Li, Xueshu Zhang, Yifeng Cui, Julia Yue Cheng, Lihua Martin, Jonathan W. Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum |
author_facet |
Liu, Yanna Richardson, Evan S. Derocher, Andrew E. Lunn, Nicholas J. Lehmler, Hans‐Joachim Li, Xueshu Zhang, Yifeng Cui, Julia Yue Cheng, Lihua Martin, Jonathan W. |
author_sort |
Liu, Yanna |
title |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum |
title_short |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum |
title_full |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum |
title_fullStr |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum |
title_full_unstemmed |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum |
title_sort |
hundreds of unrecognized halogenated contaminants discovered in polar bear serum |
publisher |
Wiley |
publishDate |
2018 |
url |
http://dx.doi.org/10.1002/anie.201809906 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201809906 https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201809906 |
genre |
Beaufort Sea Hudson Bay Ursus maritimus |
genre_facet |
Beaufort Sea Hudson Bay Ursus maritimus |
op_source |
Angewandte Chemie International Edition volume 57, issue 50, page 16401-16406 ISSN 1433-7851 1521-3773 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/anie.201809906 |
container_title |
Angewandte Chemie International Edition |
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57 |
container_issue |
50 |
container_start_page |
16401 |
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16406 |
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1810435350318809088 |