Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin‐Catalyzed Doyle–Kirmse Reaction
Abstract The first example of a biocatalytic [2,3]‐sigmatropic rearrangement reaction involving allylic sulfides and diazo reagents (Doyle–Kirmse reaction) is reported. Engineered variants of sperm whale myoglobin catalyze this synthetically valuable C−C bond‐forming transformation with high efficie...
Published in: | Angewandte Chemie International Edition |
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Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2016
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Subjects: | |
Online Access: | http://dx.doi.org/10.1002/anie.201607278 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201607278 https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201607278 |