Tau “islands” affects axonal transport in vitro and in vivo

• Published in: Alzheimer's & Dementia
• Main Authors: Moretto, Edoardo, Panzi, Chiara, Stuart, Skye, Huff, Emily, Rocque, Samantha De La, Schiavo, Giampietro
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2023
• Subjects: Tau Islands
• Online Access: http://dx.doi.org/10.1002/alz.083161

Abstract Background Tau is a protein abundantly expressed in neurons where it modulates the stability of axonal microtubules, thus contributing to the regulation of axonal transport of several organelles. Tau aggregates in a group of neurodegenerative diseases named tauopathies, which include fronto...