Treatment with C5aR1 antagonist attenuates short‐term hippocampal memory decline and prevents DAM signature in Arctic mice.

• Published in: Alzheimer's & Dementia
• Main Authors: Schartz, Nicole D, Carvalho, Klebea, Liang, Heidi Yahan, Chu, Shu‐Hui, Mortazavi, Ali, Tenner, Andrea J
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2022
• Subjects: Arctic; Doublets; Dam1
• Online Access: http://dx.doi.org/10.1002/alz.066806; https://onlinelibrary.wiley.com/doi/pdf/10.1002/alz.066806

Abstract Background Upregulation of complement genes in Alzheimer’s disease (AD) mouse models is associated with inflammation and cognitive decline. Genetic ablation of C5aR1 reduces loss of neuronal complexity and cognition in the Arctic mouse model. Inhibition of C5aR1 with PMX205 has shown succes...