A study of the peopling of Greenland using next generation sequencing of complete mitochondrial genomes
Abstract Objectives The Greenlandic population history is characterized by a number of migrations of people of various ethnicities. In this work, the analysis of the complete mtDNA genome aimed to contribute to the ongoing debate on the origin of current Greenlanders and, at the same time, to addres...
Published in: | American Journal of Physical Anthropology |
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crwiley:10.1002/ajpa.23074 2024-06-23T07:53:16+00:00 A study of the peopling of Greenland using next generation sequencing of complete mitochondrial genomes Lopopolo, Maria Børsting, Claus Pereira, Vania Morling, Niels 2016 http://dx.doi.org/10.1002/ajpa.23074 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajpa.23074 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajpa.23074 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajpa.23074 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor American Journal of Physical Anthropology volume 161, issue 4, page 698-704 ISSN 0002-9483 1096-8644 journal-article 2016 crwiley https://doi.org/10.1002/ajpa.23074 2024-06-13T04:22:30Z Abstract Objectives The Greenlandic population history is characterized by a number of migrations of people of various ethnicities. In this work, the analysis of the complete mtDNA genome aimed to contribute to the ongoing debate on the origin of current Greenlanders and, at the same time, to address the migration patterns in the Greenlandic population from a female inheritance demographic perspective. Methods We investigated the maternal genetic variation in the Greenlandic population by sequencing the whole mtDNA genome in 127 Greenlandic individuals using the Illumina MiSeq ® platform. Results All Greenlandic individuals belonged to the Inuit mtDNA lineages A2a, A2b1, and D4b1a2a1. No European haplogroup was found. Discussion The mtDNA lineages seem to support the hypothesis that the Inuit in Greenland are descendants from the Thule migration. The results also reinforce the importance of isolation and genetic drift in shaping the genetic diversity in Greenlanders. Based on the mtDNA sequences, the Greenlandic Inuit are phylogenetically close to Siberian groups and Canadian Inuit. Article in Journal/Newspaper Greenland greenlander* greenlandic inuit Thule Wiley Online Library Greenland American Journal of Physical Anthropology 161 4 698 704 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract Objectives The Greenlandic population history is characterized by a number of migrations of people of various ethnicities. In this work, the analysis of the complete mtDNA genome aimed to contribute to the ongoing debate on the origin of current Greenlanders and, at the same time, to address the migration patterns in the Greenlandic population from a female inheritance demographic perspective. Methods We investigated the maternal genetic variation in the Greenlandic population by sequencing the whole mtDNA genome in 127 Greenlandic individuals using the Illumina MiSeq ® platform. Results All Greenlandic individuals belonged to the Inuit mtDNA lineages A2a, A2b1, and D4b1a2a1. No European haplogroup was found. Discussion The mtDNA lineages seem to support the hypothesis that the Inuit in Greenland are descendants from the Thule migration. The results also reinforce the importance of isolation and genetic drift in shaping the genetic diversity in Greenlanders. Based on the mtDNA sequences, the Greenlandic Inuit are phylogenetically close to Siberian groups and Canadian Inuit. |
format |
Article in Journal/Newspaper |
author |
Lopopolo, Maria Børsting, Claus Pereira, Vania Morling, Niels |
spellingShingle |
Lopopolo, Maria Børsting, Claus Pereira, Vania Morling, Niels A study of the peopling of Greenland using next generation sequencing of complete mitochondrial genomes |
author_facet |
Lopopolo, Maria Børsting, Claus Pereira, Vania Morling, Niels |
author_sort |
Lopopolo, Maria |
title |
A study of the peopling of Greenland using next generation sequencing of complete mitochondrial genomes |
title_short |
A study of the peopling of Greenland using next generation sequencing of complete mitochondrial genomes |
title_full |
A study of the peopling of Greenland using next generation sequencing of complete mitochondrial genomes |
title_fullStr |
A study of the peopling of Greenland using next generation sequencing of complete mitochondrial genomes |
title_full_unstemmed |
A study of the peopling of Greenland using next generation sequencing of complete mitochondrial genomes |
title_sort |
study of the peopling of greenland using next generation sequencing of complete mitochondrial genomes |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1002/ajpa.23074 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajpa.23074 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajpa.23074 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajpa.23074 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlander* greenlandic inuit Thule |
genre_facet |
Greenland greenlander* greenlandic inuit Thule |
op_source |
American Journal of Physical Anthropology volume 161, issue 4, page 698-704 ISSN 0002-9483 1096-8644 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ajpa.23074 |
container_title |
American Journal of Physical Anthropology |
container_volume |
161 |
container_issue |
4 |
container_start_page |
698 |
op_container_end_page |
704 |
_version_ |
1802644837770461184 |