Brief communication: Evolution of a specific O allele (O1v G542A ) supports unique ancestry of Native Americans
ABSTRACT In this study, we explore the geographic and temporal distribution of a unique variant of the O blood group allele called O1v G542A , which has been shown to be shared among Native Americans but is rare in other populations. O1v G542A was previously reported in Native American populations i...
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crwiley:10.1002/ajpa.22292 2024-09-15T18:39:10+00:00 Brief communication: Evolution of a specific O allele (O1v G542A ) supports unique ancestry of Native Americans Villanea, Fernando A. Bolnick, Deborah A. Monroe, Cara Worl, Rosita Cambra, Rosemary Leventhal, Alan Kemp, Brian M. 2013 http://dx.doi.org/10.1002/ajpa.22292 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajpa.22292 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajpa.22292 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor American Journal of Physical Anthropology volume 151, issue 4, page 649-657 ISSN 0002-9483 1096-8644 journal-article 2013 crwiley https://doi.org/10.1002/ajpa.22292 2024-08-09T04:25:54Z ABSTRACT In this study, we explore the geographic and temporal distribution of a unique variant of the O blood group allele called O1v G542A , which has been shown to be shared among Native Americans but is rare in other populations. O1v G542A was previously reported in Native American populations in Mesoamerica and South America, and has been proposed as an ancestry informative marker. We investigated whether this allele is also found in the Tlingit and Haida, two contemporary indigenous populations from Alaska, and a pre‐Columbian population from California. If O1v G542A is present in Na‐Dene speakers (i.e., Tlingits), it would indicate that Na‐Dene speaking groups share close ancestry with other Native American groups and support a Beringian origin of the allele, consistent with the Beringian Incubation Model. If O1v G542A is found in pre‐Columbian populations, it would further support a Beringian origin of the allele, rather than a more recent introduction of the allele into the Americas via gene flow from one or more populations which have admixed with Native Americans over the past five centuries. We identified this allele in one Na‐Dene population at a frequency of 0.11, and one ancient California population at a frequency of 0.20. Our results support a Beringian origin of O1v G542A , which is distributed today among all Native American groups that have been genotyped in appreciable numbers at this locus. This result is consistent with the hypothesis that Na‐Dene and other Native American populations primarily derive their ancestry from a single source population. Am J Phys Anthropol 151:649–657, 2013. © 2013 Wiley Periodicals, Inc. Article in Journal/Newspaper tlingit Alaska Wiley Online Library American Journal of Physical Anthropology 151 4 649 657 |
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English |
description |
ABSTRACT In this study, we explore the geographic and temporal distribution of a unique variant of the O blood group allele called O1v G542A , which has been shown to be shared among Native Americans but is rare in other populations. O1v G542A was previously reported in Native American populations in Mesoamerica and South America, and has been proposed as an ancestry informative marker. We investigated whether this allele is also found in the Tlingit and Haida, two contemporary indigenous populations from Alaska, and a pre‐Columbian population from California. If O1v G542A is present in Na‐Dene speakers (i.e., Tlingits), it would indicate that Na‐Dene speaking groups share close ancestry with other Native American groups and support a Beringian origin of the allele, consistent with the Beringian Incubation Model. If O1v G542A is found in pre‐Columbian populations, it would further support a Beringian origin of the allele, rather than a more recent introduction of the allele into the Americas via gene flow from one or more populations which have admixed with Native Americans over the past five centuries. We identified this allele in one Na‐Dene population at a frequency of 0.11, and one ancient California population at a frequency of 0.20. Our results support a Beringian origin of O1v G542A , which is distributed today among all Native American groups that have been genotyped in appreciable numbers at this locus. This result is consistent with the hypothesis that Na‐Dene and other Native American populations primarily derive their ancestry from a single source population. Am J Phys Anthropol 151:649–657, 2013. © 2013 Wiley Periodicals, Inc. |
format |
Article in Journal/Newspaper |
author |
Villanea, Fernando A. Bolnick, Deborah A. Monroe, Cara Worl, Rosita Cambra, Rosemary Leventhal, Alan Kemp, Brian M. |
spellingShingle |
Villanea, Fernando A. Bolnick, Deborah A. Monroe, Cara Worl, Rosita Cambra, Rosemary Leventhal, Alan Kemp, Brian M. Brief communication: Evolution of a specific O allele (O1v G542A ) supports unique ancestry of Native Americans |
author_facet |
Villanea, Fernando A. Bolnick, Deborah A. Monroe, Cara Worl, Rosita Cambra, Rosemary Leventhal, Alan Kemp, Brian M. |
author_sort |
Villanea, Fernando A. |
title |
Brief communication: Evolution of a specific O allele (O1v G542A ) supports unique ancestry of Native Americans |
title_short |
Brief communication: Evolution of a specific O allele (O1v G542A ) supports unique ancestry of Native Americans |
title_full |
Brief communication: Evolution of a specific O allele (O1v G542A ) supports unique ancestry of Native Americans |
title_fullStr |
Brief communication: Evolution of a specific O allele (O1v G542A ) supports unique ancestry of Native Americans |
title_full_unstemmed |
Brief communication: Evolution of a specific O allele (O1v G542A ) supports unique ancestry of Native Americans |
title_sort |
brief communication: evolution of a specific o allele (o1v g542a ) supports unique ancestry of native americans |
publisher |
Wiley |
publishDate |
2013 |
url |
http://dx.doi.org/10.1002/ajpa.22292 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajpa.22292 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajpa.22292 |
genre |
tlingit Alaska |
genre_facet |
tlingit Alaska |
op_source |
American Journal of Physical Anthropology volume 151, issue 4, page 649-657 ISSN 0002-9483 1096-8644 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ajpa.22292 |
container_title |
American Journal of Physical Anthropology |
container_volume |
151 |
container_issue |
4 |
container_start_page |
649 |
op_container_end_page |
657 |
_version_ |
1810483561411641344 |