Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort
Abstract Although the genetic determinants of personality have been intensively investigated especially since Cloninger proposed his psychobiological model of temperament and character, findings to date remain inconclusive and very few studies have addressed the topic in large population cohorts. In...
Published in: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
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crwiley:10.1002/ajmg.b.30908 2024-06-02T08:12:02+00:00 Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort Nyman, Emma S. Loukola, Anu Varilo, Teppo Ekelund, Jesper Veijola, Juha Joukamaa, Matti Taanila, Anja Pouta, Anneli Miettunen, Jouko Freimer, Nelson Järvelin, Marjo‐Riitta Peltonen, Leena 2009 http://dx.doi.org/10.1002/ajmg.b.30908 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.b.30908 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.b.30908 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor American Journal of Medical Genetics Part B: Neuropsychiatric Genetics volume 150B, issue 6, page 854-865 ISSN 1552-4841 1552-485X journal-article 2009 crwiley https://doi.org/10.1002/ajmg.b.30908 2024-05-03T11:44:54Z Abstract Although the genetic determinants of personality have been intensively investigated especially since Cloninger proposed his psychobiological model of temperament and character, findings to date remain inconclusive and very few studies have addressed the topic in large population cohorts. In the current study we investigated one gene family in its entirety by addressing the role of all known dopamine receptor genes, DRD1 – DRD5 , on Cloninger's temperament traits in a Finnish population‐based birth cohort. The study sample (n = 1,434) was ascertained from the Northern Finland Birth Cohort 1966 with over 5,000 study individuals tested at the age of 31 years. We utilized the genetic homogeneity and genealogical structure of this population to uncover putative effects of these genes on temperament traits at the population level. Our strategy utilizing a large birth cohort and its well established genealogical structure represents an optimal design for studying normally distributed traits. We also wished to provide a comprehensive view to one biologically relevant gene family instead of testing single candidate genes. We report evidence of association of several SNPs at the 5′ end of dopamine receptor D2 ( DRD2 ) with Novelty seeking (low) and Harm avoidance (high), and at the 3′ end of DRD2 with Persistence. The strongest evidence of association emerged from females. Our study supports the involvement of the dopamine pathway in temperament traits, in particular underlining the role of DRD2 in Novelty seeking, Harm avoidance and Persistence. © 2008 Wiley‐Liss, Inc. Article in Journal/Newspaper Northern Finland Wiley Online Library American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B 6 854 865 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract Although the genetic determinants of personality have been intensively investigated especially since Cloninger proposed his psychobiological model of temperament and character, findings to date remain inconclusive and very few studies have addressed the topic in large population cohorts. In the current study we investigated one gene family in its entirety by addressing the role of all known dopamine receptor genes, DRD1 – DRD5 , on Cloninger's temperament traits in a Finnish population‐based birth cohort. The study sample (n = 1,434) was ascertained from the Northern Finland Birth Cohort 1966 with over 5,000 study individuals tested at the age of 31 years. We utilized the genetic homogeneity and genealogical structure of this population to uncover putative effects of these genes on temperament traits at the population level. Our strategy utilizing a large birth cohort and its well established genealogical structure represents an optimal design for studying normally distributed traits. We also wished to provide a comprehensive view to one biologically relevant gene family instead of testing single candidate genes. We report evidence of association of several SNPs at the 5′ end of dopamine receptor D2 ( DRD2 ) with Novelty seeking (low) and Harm avoidance (high), and at the 3′ end of DRD2 with Persistence. The strongest evidence of association emerged from females. Our study supports the involvement of the dopamine pathway in temperament traits, in particular underlining the role of DRD2 in Novelty seeking, Harm avoidance and Persistence. © 2008 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Nyman, Emma S. Loukola, Anu Varilo, Teppo Ekelund, Jesper Veijola, Juha Joukamaa, Matti Taanila, Anja Pouta, Anneli Miettunen, Jouko Freimer, Nelson Järvelin, Marjo‐Riitta Peltonen, Leena |
spellingShingle |
Nyman, Emma S. Loukola, Anu Varilo, Teppo Ekelund, Jesper Veijola, Juha Joukamaa, Matti Taanila, Anja Pouta, Anneli Miettunen, Jouko Freimer, Nelson Järvelin, Marjo‐Riitta Peltonen, Leena Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort |
author_facet |
Nyman, Emma S. Loukola, Anu Varilo, Teppo Ekelund, Jesper Veijola, Juha Joukamaa, Matti Taanila, Anja Pouta, Anneli Miettunen, Jouko Freimer, Nelson Järvelin, Marjo‐Riitta Peltonen, Leena |
author_sort |
Nyman, Emma S. |
title |
Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort |
title_short |
Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort |
title_full |
Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort |
title_fullStr |
Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort |
title_full_unstemmed |
Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort |
title_sort |
impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort |
publisher |
Wiley |
publishDate |
2009 |
url |
http://dx.doi.org/10.1002/ajmg.b.30908 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.b.30908 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.b.30908 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics volume 150B, issue 6, page 854-865 ISSN 1552-4841 1552-485X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ajmg.b.30908 |
container_title |
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
container_volume |
150B |
container_issue |
6 |
container_start_page |
854 |
op_container_end_page |
865 |
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1800758355416842240 |