Adenine nucleotides, serotonin, and aggregation properties of platelets of blue foxes ( Alopex lagopus) with the Chediak‐Higashi syndrome
Abstract Bleeding times, concentrations of serotonin in whole blood, and concentrations of adenine nucleotides as well as aggregation properties of platelets were examined in 18 blue foxes with Chediak‐Higashi–like syndrome (CHS) and 16 controls. A claw of each ketamine‐sedated fox was cut until ble...
Published in: | American Journal of Medical Genetics |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
1990
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1002/ajmg.1320350312 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.1320350312 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.1320350312 |
id |
crwiley:10.1002/ajmg.1320350312 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1002/ajmg.1320350312 2024-06-02T07:54:52+00:00 Adenine nucleotides, serotonin, and aggregation properties of platelets of blue foxes ( Alopex lagopus) with the Chediak‐Higashi syndrome Sjaastad, Øystein V. Blom, Anne K. Stormorken, Helge Nes, Norodd 1990 http://dx.doi.org/10.1002/ajmg.1320350312 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.1320350312 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.1320350312 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor American Journal of Medical Genetics volume 35, issue 3, page 373-378 ISSN 0148-7299 1096-8628 journal-article 1990 crwiley https://doi.org/10.1002/ajmg.1320350312 2024-05-03T11:33:48Z Abstract Bleeding times, concentrations of serotonin in whole blood, and concentrations of adenine nucleotides as well as aggregation properties of platelets were examined in 18 blue foxes with Chediak‐Higashi–like syndrome (CHS) and 16 controls. A claw of each ketamine‐sedated fox was cut until bleeding started and the bleeding time was recorded as the time from the first to the last drop. The bleeding time was greatly increased in CHS foxes. Platelet counts of CHS foxes were normal, but aggregation induced by adenosine diphosphate (ADP), serotonin, collagen, and arachidonate was impaired. Adrenaline and serotonin potentiated the aggregatory effect of ADP on control as well as on CHS platelets. The mean concentration of ADP in CHS platelets was about one‐third that in controls, whereas adenosine triphosphate (ATP) was approximately one‐half that in controls. Serotonin could not, in most cases, be detected in blood of CHS foxes. These findings suggest that the prolonged bleeding time in the CHS foxes is, at least partly, due to a storage pool deficiency. The drastically reduced, and in some cases absent, aggregation of CHS platelets in response to arachidonate suggests that defective arachidonate metabolism contributes to the impaired hemostasis. Article in Journal/Newspaper Alopex lagopus Wiley Online Library American Journal of Medical Genetics 35 3 373 378 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Abstract Bleeding times, concentrations of serotonin in whole blood, and concentrations of adenine nucleotides as well as aggregation properties of platelets were examined in 18 blue foxes with Chediak‐Higashi–like syndrome (CHS) and 16 controls. A claw of each ketamine‐sedated fox was cut until bleeding started and the bleeding time was recorded as the time from the first to the last drop. The bleeding time was greatly increased in CHS foxes. Platelet counts of CHS foxes were normal, but aggregation induced by adenosine diphosphate (ADP), serotonin, collagen, and arachidonate was impaired. Adrenaline and serotonin potentiated the aggregatory effect of ADP on control as well as on CHS platelets. The mean concentration of ADP in CHS platelets was about one‐third that in controls, whereas adenosine triphosphate (ATP) was approximately one‐half that in controls. Serotonin could not, in most cases, be detected in blood of CHS foxes. These findings suggest that the prolonged bleeding time in the CHS foxes is, at least partly, due to a storage pool deficiency. The drastically reduced, and in some cases absent, aggregation of CHS platelets in response to arachidonate suggests that defective arachidonate metabolism contributes to the impaired hemostasis. |
format |
Article in Journal/Newspaper |
author |
Sjaastad, Øystein V. Blom, Anne K. Stormorken, Helge Nes, Norodd |
spellingShingle |
Sjaastad, Øystein V. Blom, Anne K. Stormorken, Helge Nes, Norodd Adenine nucleotides, serotonin, and aggregation properties of platelets of blue foxes ( Alopex lagopus) with the Chediak‐Higashi syndrome |
author_facet |
Sjaastad, Øystein V. Blom, Anne K. Stormorken, Helge Nes, Norodd |
author_sort |
Sjaastad, Øystein V. |
title |
Adenine nucleotides, serotonin, and aggregation properties of platelets of blue foxes ( Alopex lagopus) with the Chediak‐Higashi syndrome |
title_short |
Adenine nucleotides, serotonin, and aggregation properties of platelets of blue foxes ( Alopex lagopus) with the Chediak‐Higashi syndrome |
title_full |
Adenine nucleotides, serotonin, and aggregation properties of platelets of blue foxes ( Alopex lagopus) with the Chediak‐Higashi syndrome |
title_fullStr |
Adenine nucleotides, serotonin, and aggregation properties of platelets of blue foxes ( Alopex lagopus) with the Chediak‐Higashi syndrome |
title_full_unstemmed |
Adenine nucleotides, serotonin, and aggregation properties of platelets of blue foxes ( Alopex lagopus) with the Chediak‐Higashi syndrome |
title_sort |
adenine nucleotides, serotonin, and aggregation properties of platelets of blue foxes ( alopex lagopus) with the chediak‐higashi syndrome |
publisher |
Wiley |
publishDate |
1990 |
url |
http://dx.doi.org/10.1002/ajmg.1320350312 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.1320350312 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.1320350312 |
genre |
Alopex lagopus |
genre_facet |
Alopex lagopus |
op_source |
American Journal of Medical Genetics volume 35, issue 3, page 373-378 ISSN 0148-7299 1096-8628 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ajmg.1320350312 |
container_title |
American Journal of Medical Genetics |
container_volume |
35 |
container_issue |
3 |
container_start_page |
373 |
op_container_end_page |
378 |
_version_ |
1800744051831472128 |