Persistent genetic isolation in outport Newfoundland
Abstract The historical development of genetic isolation has been evaluated for three outport Newfoundland study areas. An attempt was made to ascertain all livebirths in each study area, and determine the parentage of each. Data from records of baptism and marriage were used for this, supplemented...
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crwiley:10.1002/ajmg.1320270410 2024-10-13T14:09:06+00:00 Persistent genetic isolation in outport Newfoundland Bear, J. C. Nemec, T. F. Kennedy, J. C. Marshall, W. H. Power, A. A. Kolonel, V. M. Burke, G. B. Opitz, John M. Reynolds, James F. 1987 http://dx.doi.org/10.1002/ajmg.1320270410 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.1320270410 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.1320270410 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor American Journal of Medical Genetics volume 27, issue 4, page 807-830 ISSN 0148-7299 1096-8628 journal-article 1987 crwiley https://doi.org/10.1002/ajmg.1320270410 2024-09-17T04:49:45Z Abstract The historical development of genetic isolation has been evaluated for three outport Newfoundland study areas. An attempt was made to ascertain all livebirths in each study area, and determine the parentage of each. Data from records of baptism and marriage were used for this, supplemented with other historical and ethnographic information. Parent–offspring migration was used as a measure of genetic exchange between subpopulations within study areas, and gene flow into the study areas. Currently, 1–8% of parents originate outside the study areas; these rates are low compared to earlier periods, and compared to present‐day rates for European isolate populations. Average kinship was estimated, to measure genetic relatedness within and between subpopulations of each area and the potential for random inbreeding; these values, which are minimum estimates, are now at historically high levels. Increased migration into the study areas, which would decrease average kinship, is not likely. Thus, any regionally or locally elevated frequencies of deleterious alleles will persist, and must be taken into account in providing genetic counseling and evaluating the utility of local screening programs. Article in Journal/Newspaper Newfoundland Wiley Online Library American Journal of Medical Genetics 27 4 807 830 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract The historical development of genetic isolation has been evaluated for three outport Newfoundland study areas. An attempt was made to ascertain all livebirths in each study area, and determine the parentage of each. Data from records of baptism and marriage were used for this, supplemented with other historical and ethnographic information. Parent–offspring migration was used as a measure of genetic exchange between subpopulations within study areas, and gene flow into the study areas. Currently, 1–8% of parents originate outside the study areas; these rates are low compared to earlier periods, and compared to present‐day rates for European isolate populations. Average kinship was estimated, to measure genetic relatedness within and between subpopulations of each area and the potential for random inbreeding; these values, which are minimum estimates, are now at historically high levels. Increased migration into the study areas, which would decrease average kinship, is not likely. Thus, any regionally or locally elevated frequencies of deleterious alleles will persist, and must be taken into account in providing genetic counseling and evaluating the utility of local screening programs. |
format |
Article in Journal/Newspaper |
author |
Bear, J. C. Nemec, T. F. Kennedy, J. C. Marshall, W. H. Power, A. A. Kolonel, V. M. Burke, G. B. Opitz, John M. Reynolds, James F. |
spellingShingle |
Bear, J. C. Nemec, T. F. Kennedy, J. C. Marshall, W. H. Power, A. A. Kolonel, V. M. Burke, G. B. Opitz, John M. Reynolds, James F. Persistent genetic isolation in outport Newfoundland |
author_facet |
Bear, J. C. Nemec, T. F. Kennedy, J. C. Marshall, W. H. Power, A. A. Kolonel, V. M. Burke, G. B. Opitz, John M. Reynolds, James F. |
author_sort |
Bear, J. C. |
title |
Persistent genetic isolation in outport Newfoundland |
title_short |
Persistent genetic isolation in outport Newfoundland |
title_full |
Persistent genetic isolation in outport Newfoundland |
title_fullStr |
Persistent genetic isolation in outport Newfoundland |
title_full_unstemmed |
Persistent genetic isolation in outport Newfoundland |
title_sort |
persistent genetic isolation in outport newfoundland |
publisher |
Wiley |
publishDate |
1987 |
url |
http://dx.doi.org/10.1002/ajmg.1320270410 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.1320270410 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.1320270410 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
American Journal of Medical Genetics volume 27, issue 4, page 807-830 ISSN 0148-7299 1096-8628 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ajmg.1320270410 |
container_title |
American Journal of Medical Genetics |
container_volume |
27 |
container_issue |
4 |
container_start_page |
807 |
op_container_end_page |
830 |
_version_ |
1812815957601550336 |