Features of the immune system and levels of blood transport components in residents of the arctic of the Russian Federation
Abstract Changes in the immune status and the content of blood transport components reflect adaptations in the human body in response to adverse factors, showcasing the organism's adaptive capabilities and functional state. In this study, we aimed to determine the features of the immune system...
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crwiley:10.1002/ajhb.24136 2024-09-15T18:18:55+00:00 Features of the immune system and levels of blood transport components in residents of the arctic of the Russian Federation Pashinskaya, Ksenya O. Samodova, Anna V. Dobrodeeva, Liliya K. 2024 http://dx.doi.org/10.1002/ajhb.24136 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajhb.24136 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor American Journal of Human Biology ISSN 1042-0533 1520-6300 journal-article 2024 crwiley https://doi.org/10.1002/ajhb.24136 2024-07-23T04:15:57Z Abstract Changes in the immune status and the content of blood transport components reflect adaptations in the human body in response to adverse factors, showcasing the organism's adaptive capabilities and functional state. In this study, we aimed to determine the features of the immune system and levels of transport components of the blood system in residents of the Arctic of the Russian Federation. Methods The peripheral venous blood of 191 residents of the Arctic of the Russian Federation (Murmansk Oblast) aged 21–55 analyzed comprehensively. Blood was sampled from the ulnar vein on an empty stomach in the morning. The hemogram, phagocytic activity of neutrophils, lymphocyte content with CD3, CD4, CD8, CD10, CD19, CD16, CD71, CD25, HLA‐DR and CD95 phenotypes, concentrations of cytokines: TNF‐ α , IFN‐ γ , IL‐6, IL‐10, extracellular receptor pool: sCD71, sCD62L, sApo‐1/Fas, sFasL, circulating immune complexes (CIC) and blood transport components: haptoglobin (Hp), transferrin, IgM, IgG, IgA, IgE (immunoglobulins M, G, A and E) low‐density lipoproteins (LDL), and high density lipoprotein (HDL) were evaluated. The results were analyzed using descriptive statistics and comparative, factorial, and regression analyses. Results Residents of the Murmansk Oblast exhibit a high prevalence of erythrocytosis (62.3%), thrombocytosis (25.0%), leukocytosis (20.1%), and increased hemoglobin (Hb) concentrations (42.5%), coupled with a significantly decreased level of active phagocytes (47.6%). A significantly decreased level of lymphocytes with phenotypes CD3 (92.4%), CD4 (40.4%), CD71 (62.3%) was revealed, coupled with the activation of lymphocytes with phenotypes CD16 (50.1%), CD8 (37.5%), CD19 (15.9%) and increased concentrations of pro‐inflammatory IFN‐ γ (47.9%), IL‐6 (33.3%), and TNF‐ α (20.1%). Elevated levels of sCD71 (56.6%), sCD62L (32.1%), sApo‐1/Fas (22.1%), sFasL (10.2%), and autoantibodies to double‐stranded DNA (57.1%), RNA (10.4%), and oLDL (oxidized‐modified LDL) (16.3%) were recorded in residents of the ... Article in Journal/Newspaper Murmansk Oblast Wiley Online Library American Journal of Human Biology |
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Wiley Online Library |
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English |
description |
Abstract Changes in the immune status and the content of blood transport components reflect adaptations in the human body in response to adverse factors, showcasing the organism's adaptive capabilities and functional state. In this study, we aimed to determine the features of the immune system and levels of transport components of the blood system in residents of the Arctic of the Russian Federation. Methods The peripheral venous blood of 191 residents of the Arctic of the Russian Federation (Murmansk Oblast) aged 21–55 analyzed comprehensively. Blood was sampled from the ulnar vein on an empty stomach in the morning. The hemogram, phagocytic activity of neutrophils, lymphocyte content with CD3, CD4, CD8, CD10, CD19, CD16, CD71, CD25, HLA‐DR and CD95 phenotypes, concentrations of cytokines: TNF‐ α , IFN‐ γ , IL‐6, IL‐10, extracellular receptor pool: sCD71, sCD62L, sApo‐1/Fas, sFasL, circulating immune complexes (CIC) and blood transport components: haptoglobin (Hp), transferrin, IgM, IgG, IgA, IgE (immunoglobulins M, G, A and E) low‐density lipoproteins (LDL), and high density lipoprotein (HDL) were evaluated. The results were analyzed using descriptive statistics and comparative, factorial, and regression analyses. Results Residents of the Murmansk Oblast exhibit a high prevalence of erythrocytosis (62.3%), thrombocytosis (25.0%), leukocytosis (20.1%), and increased hemoglobin (Hb) concentrations (42.5%), coupled with a significantly decreased level of active phagocytes (47.6%). A significantly decreased level of lymphocytes with phenotypes CD3 (92.4%), CD4 (40.4%), CD71 (62.3%) was revealed, coupled with the activation of lymphocytes with phenotypes CD16 (50.1%), CD8 (37.5%), CD19 (15.9%) and increased concentrations of pro‐inflammatory IFN‐ γ (47.9%), IL‐6 (33.3%), and TNF‐ α (20.1%). Elevated levels of sCD71 (56.6%), sCD62L (32.1%), sApo‐1/Fas (22.1%), sFasL (10.2%), and autoantibodies to double‐stranded DNA (57.1%), RNA (10.4%), and oLDL (oxidized‐modified LDL) (16.3%) were recorded in residents of the ... |
format |
Article in Journal/Newspaper |
author |
Pashinskaya, Ksenya O. Samodova, Anna V. Dobrodeeva, Liliya K. |
spellingShingle |
Pashinskaya, Ksenya O. Samodova, Anna V. Dobrodeeva, Liliya K. Features of the immune system and levels of blood transport components in residents of the arctic of the Russian Federation |
author_facet |
Pashinskaya, Ksenya O. Samodova, Anna V. Dobrodeeva, Liliya K. |
author_sort |
Pashinskaya, Ksenya O. |
title |
Features of the immune system and levels of blood transport components in residents of the arctic of the Russian Federation |
title_short |
Features of the immune system and levels of blood transport components in residents of the arctic of the Russian Federation |
title_full |
Features of the immune system and levels of blood transport components in residents of the arctic of the Russian Federation |
title_fullStr |
Features of the immune system and levels of blood transport components in residents of the arctic of the Russian Federation |
title_full_unstemmed |
Features of the immune system and levels of blood transport components in residents of the arctic of the Russian Federation |
title_sort |
features of the immune system and levels of blood transport components in residents of the arctic of the russian federation |
publisher |
Wiley |
publishDate |
2024 |
url |
http://dx.doi.org/10.1002/ajhb.24136 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajhb.24136 |
genre |
Murmansk Oblast |
genre_facet |
Murmansk Oblast |
op_source |
American Journal of Human Biology ISSN 1042-0533 1520-6300 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ajhb.24136 |
container_title |
American Journal of Human Biology |
_version_ |
1810457017455738880 |