Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates
Abstract Objectives Recent research suggests that brown adipose tissue (BAT) plays a functional role in non‐shivering thermogenesis; however, few studies have examined population variation in BAT or its relationship with other mechanisms of adaptation to cold stress. This study characterized BAT the...
Published in: | American Journal of Human Biology |
---|---|
Main Authors: | , , , , , , , , , , , |
Other Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2022
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1002/ajhb.23723 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajhb.23723 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajhb.23723 https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/ajhb.23723 |
id |
crwiley:10.1002/ajhb.23723 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1002/ajhb.23723 2024-06-09T07:50:08+00:00 Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates Levy, Stephanie B. Klimova, Tatiana M. Zakharova, Raisa N. Fedorov, Afanasiy I. Fedorova, Valentina I. Baltakhinova, Marina E. Bondy, Madison Atallah, Dania Thompson‐Vasquez, Jennah Dong, Kaylin Debertine, Anne Leonard, William R. Directorate for Social, Behavioral and Economic Sciences Leakey Foundation Northwestern University 2022 http://dx.doi.org/10.1002/ajhb.23723 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajhb.23723 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajhb.23723 https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/ajhb.23723 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#am http://onlinelibrary.wiley.com/termsAndConditions#vor American Journal of Human Biology volume 34, issue 6 ISSN 1042-0533 1520-6300 journal-article 2022 crwiley https://doi.org/10.1002/ajhb.23723 2024-05-16T14:24:52Z Abstract Objectives Recent research suggests that brown adipose tissue (BAT) plays a functional role in non‐shivering thermogenesis; however, few studies have examined population variation in BAT or its relationship with other mechanisms of adaptation to cold stress. This study characterized BAT thermogenesis and other adaptive responses to low temperatures among Indigenous Siberian young adults and young adults living near Chicago, IL. Materials and methods We recruited 72 Yakut participants (42 females; 30 males) and 54 participants in Evanston, IL (40 females; 14 males). Anthropometric dimensions and resting metabolic rate (RMR) were measured, and we calculated percent divergence in RMR from expected values (divRMR). We also quantified change in supraclavicular temperature, sternum temperature, and energy expenditure after a mild cooling condition. Results Participants in Yakutia were less likely to shiver during the cooling condition ( p < .05) and exhibited significantly greater evidence of BAT thermogenesis, warmer sternum temperatures, and higher divRMR than participants in Evanston ( p < .05). Additionally, the relationship between change in supraclavicular temperature and energy expenditure differed between the two samples. Conclusions Yakut young adults displayed greater evidence of BAT thermogenesis in response to mild cooling compared with young adults living near Chicago, IL. Furthermore, the relationship between BAT thermogenesis and change in energy expenditure appears to be stronger among Yakut adults. Adults that exhibited greater metabolic response to cold stress, such as higher BAT thermogenesis and divRMR, maintained warmer sternum temperatures. These results highlight the degree to which adaptation to cold climates involves multiple integrated biological pathways. Article in Journal/Newspaper Yakut Yakutia Siberia Wiley Online Library Shiver ENVELOPE(-61.417,-61.417,-65.050,-65.050) American Journal of Human Biology 34 6 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Abstract Objectives Recent research suggests that brown adipose tissue (BAT) plays a functional role in non‐shivering thermogenesis; however, few studies have examined population variation in BAT or its relationship with other mechanisms of adaptation to cold stress. This study characterized BAT thermogenesis and other adaptive responses to low temperatures among Indigenous Siberian young adults and young adults living near Chicago, IL. Materials and methods We recruited 72 Yakut participants (42 females; 30 males) and 54 participants in Evanston, IL (40 females; 14 males). Anthropometric dimensions and resting metabolic rate (RMR) were measured, and we calculated percent divergence in RMR from expected values (divRMR). We also quantified change in supraclavicular temperature, sternum temperature, and energy expenditure after a mild cooling condition. Results Participants in Yakutia were less likely to shiver during the cooling condition ( p < .05) and exhibited significantly greater evidence of BAT thermogenesis, warmer sternum temperatures, and higher divRMR than participants in Evanston ( p < .05). Additionally, the relationship between change in supraclavicular temperature and energy expenditure differed between the two samples. Conclusions Yakut young adults displayed greater evidence of BAT thermogenesis in response to mild cooling compared with young adults living near Chicago, IL. Furthermore, the relationship between BAT thermogenesis and change in energy expenditure appears to be stronger among Yakut adults. Adults that exhibited greater metabolic response to cold stress, such as higher BAT thermogenesis and divRMR, maintained warmer sternum temperatures. These results highlight the degree to which adaptation to cold climates involves multiple integrated biological pathways. |
author2 |
Directorate for Social, Behavioral and Economic Sciences Leakey Foundation Northwestern University |
format |
Article in Journal/Newspaper |
author |
Levy, Stephanie B. Klimova, Tatiana M. Zakharova, Raisa N. Fedorov, Afanasiy I. Fedorova, Valentina I. Baltakhinova, Marina E. Bondy, Madison Atallah, Dania Thompson‐Vasquez, Jennah Dong, Kaylin Debertine, Anne Leonard, William R. |
spellingShingle |
Levy, Stephanie B. Klimova, Tatiana M. Zakharova, Raisa N. Fedorov, Afanasiy I. Fedorova, Valentina I. Baltakhinova, Marina E. Bondy, Madison Atallah, Dania Thompson‐Vasquez, Jennah Dong, Kaylin Debertine, Anne Leonard, William R. Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates |
author_facet |
Levy, Stephanie B. Klimova, Tatiana M. Zakharova, Raisa N. Fedorov, Afanasiy I. Fedorova, Valentina I. Baltakhinova, Marina E. Bondy, Madison Atallah, Dania Thompson‐Vasquez, Jennah Dong, Kaylin Debertine, Anne Leonard, William R. |
author_sort |
Levy, Stephanie B. |
title |
Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates |
title_short |
Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates |
title_full |
Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates |
title_fullStr |
Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates |
title_full_unstemmed |
Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates |
title_sort |
brown adipose tissue thermogenesis among young adults in northeastern siberia and midwest united states and its relationship with other biological adaptations to cold climates |
publisher |
Wiley |
publishDate |
2022 |
url |
http://dx.doi.org/10.1002/ajhb.23723 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajhb.23723 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajhb.23723 https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/ajhb.23723 |
long_lat |
ENVELOPE(-61.417,-61.417,-65.050,-65.050) |
geographic |
Shiver |
geographic_facet |
Shiver |
genre |
Yakut Yakutia Siberia |
genre_facet |
Yakut Yakutia Siberia |
op_source |
American Journal of Human Biology volume 34, issue 6 ISSN 1042-0533 1520-6300 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#am http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ajhb.23723 |
container_title |
American Journal of Human Biology |
container_volume |
34 |
container_issue |
6 |
_version_ |
1801383336775516160 |