Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the GOCADAN Study
Abstract Increasing incidence of cardiovascular disease in traditionally low‐risk Alaskan Eskimos is a cause for concern. The purpose of this study was to examine the genetic and environmental correlations of low‐density lipoprotein (LDL) subfractions with obesity‐related factors in Alaskan Eskimos,...
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crwiley:10.1002/ajhb.20527 2024-06-09T07:45:45+00:00 Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the GOCADAN Study Voruganti, V. Saroja Cai, Guowen Cole, Shelley A. Freeland‐Graves, Jeanne H. Laston, Sandra Wenger, Charlotte R. MacCluer, Jean W. Dyke, Bennett Devereux, Richard Ebbesson, Sven O.E. Fabsitz, Richard R. Howard, Barbara V. Comuzzie, Anthony G. 2006 http://dx.doi.org/10.1002/ajhb.20527 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajhb.20527 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajhb.20527 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor American Journal of Human Biology volume 18, issue 4, page 525-531 ISSN 1042-0533 1520-6300 journal-article 2006 crwiley https://doi.org/10.1002/ajhb.20527 2024-05-16T14:23:17Z Abstract Increasing incidence of cardiovascular disease in traditionally low‐risk Alaskan Eskimos is a cause for concern. The purpose of this study was to examine the genetic and environmental correlations of low‐density lipoprotein (LDL) subfractions with obesity‐related factors in Alaskan Eskimos, using data from the first 954 participants of the Genetics of Coronary Artery Disease in Alaska Natives Study. Estimates of genetic and environmental influence were calculated using a maximum likelihood variance component method implemented in SOLAR. Mean values of weight, body mass index (BMI), and waist were 73.4 ± 0.5 kg, 27.6 ± 0.2 kg/m 2 , and 88.0 ± 0.4 cm, respectively. LDL, and its small (LDL1), medium (LDL2), and large (LDL3) subfractions, had mean values of 115.8 ± 1.2 mg/dl, 8.3 ± 0.4 mg/dl, 19.6 ± 0.8 mg/dl, and 71.5 ± 1.5 mg/dl, respectively. Bivariate analysis displayed significant genetic correlations between LDL subfractions and obesity‐related factors: LDL1 with BMI (rho G = 0.67, P < 0.05), waist (rho G = 0.80, P < 0.001), and subscapular and tricep skinfolds (rho G = 0.93, P < 0.005, and rho G = 0.78, P < 0.05, respectively); LDL2 with BMI (rho G = 0.52, P < 0.05), waist (rho G = 0.46, P < 0.05), and tricep skinfold (rho G = 0.60, P < 0.05); and mean LDL size with BMI (rho G = −0.36), waist (rho G = −0.42,), and subscapular and tricep skinfolds (rho G = −0.44 and −0.43, respectively) ( P < 0.005). These results show that a common set of genes is influencing LDL size and obesity‐related factors in Alaskan Eskimos. Am. J. Hum. Biol. 18:525–531, 2006. © 2006 Wiley‐Liss, Inc. Article in Journal/Newspaper eskimo* Alaska Wiley Online Library Rho ENVELOPE(-63.000,-63.000,-64.300,-64.300) American Journal of Human Biology 18 4 525 531 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract Increasing incidence of cardiovascular disease in traditionally low‐risk Alaskan Eskimos is a cause for concern. The purpose of this study was to examine the genetic and environmental correlations of low‐density lipoprotein (LDL) subfractions with obesity‐related factors in Alaskan Eskimos, using data from the first 954 participants of the Genetics of Coronary Artery Disease in Alaska Natives Study. Estimates of genetic and environmental influence were calculated using a maximum likelihood variance component method implemented in SOLAR. Mean values of weight, body mass index (BMI), and waist were 73.4 ± 0.5 kg, 27.6 ± 0.2 kg/m 2 , and 88.0 ± 0.4 cm, respectively. LDL, and its small (LDL1), medium (LDL2), and large (LDL3) subfractions, had mean values of 115.8 ± 1.2 mg/dl, 8.3 ± 0.4 mg/dl, 19.6 ± 0.8 mg/dl, and 71.5 ± 1.5 mg/dl, respectively. Bivariate analysis displayed significant genetic correlations between LDL subfractions and obesity‐related factors: LDL1 with BMI (rho G = 0.67, P < 0.05), waist (rho G = 0.80, P < 0.001), and subscapular and tricep skinfolds (rho G = 0.93, P < 0.005, and rho G = 0.78, P < 0.05, respectively); LDL2 with BMI (rho G = 0.52, P < 0.05), waist (rho G = 0.46, P < 0.05), and tricep skinfold (rho G = 0.60, P < 0.05); and mean LDL size with BMI (rho G = −0.36), waist (rho G = −0.42,), and subscapular and tricep skinfolds (rho G = −0.44 and −0.43, respectively) ( P < 0.005). These results show that a common set of genes is influencing LDL size and obesity‐related factors in Alaskan Eskimos. Am. J. Hum. Biol. 18:525–531, 2006. © 2006 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Voruganti, V. Saroja Cai, Guowen Cole, Shelley A. Freeland‐Graves, Jeanne H. Laston, Sandra Wenger, Charlotte R. MacCluer, Jean W. Dyke, Bennett Devereux, Richard Ebbesson, Sven O.E. Fabsitz, Richard R. Howard, Barbara V. Comuzzie, Anthony G. |
spellingShingle |
Voruganti, V. Saroja Cai, Guowen Cole, Shelley A. Freeland‐Graves, Jeanne H. Laston, Sandra Wenger, Charlotte R. MacCluer, Jean W. Dyke, Bennett Devereux, Richard Ebbesson, Sven O.E. Fabsitz, Richard R. Howard, Barbara V. Comuzzie, Anthony G. Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the GOCADAN Study |
author_facet |
Voruganti, V. Saroja Cai, Guowen Cole, Shelley A. Freeland‐Graves, Jeanne H. Laston, Sandra Wenger, Charlotte R. MacCluer, Jean W. Dyke, Bennett Devereux, Richard Ebbesson, Sven O.E. Fabsitz, Richard R. Howard, Barbara V. Comuzzie, Anthony G. |
author_sort |
Voruganti, V. Saroja |
title |
Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the GOCADAN Study |
title_short |
Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the GOCADAN Study |
title_full |
Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the GOCADAN Study |
title_fullStr |
Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the GOCADAN Study |
title_full_unstemmed |
Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the GOCADAN Study |
title_sort |
common set of genes regulates low‐density lipoprotein size and obesity‐related factors in alaskan eskimos: results from the gocadan study |
publisher |
Wiley |
publishDate |
2006 |
url |
http://dx.doi.org/10.1002/ajhb.20527 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajhb.20527 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajhb.20527 |
long_lat |
ENVELOPE(-63.000,-63.000,-64.300,-64.300) |
geographic |
Rho |
geographic_facet |
Rho |
genre |
eskimo* Alaska |
genre_facet |
eskimo* Alaska |
op_source |
American Journal of Human Biology volume 18, issue 4, page 525-531 ISSN 1042-0533 1520-6300 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ajhb.20527 |
container_title |
American Journal of Human Biology |
container_volume |
18 |
container_issue |
4 |
container_start_page |
525 |
op_container_end_page |
531 |
_version_ |
1801375280739123200 |