Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing
Abstract Due to thiolation of poly‐ and oligosaccharides numerous favorable properties for tissue engineering and wound healing can be introduced. Poly‐ and oligosaccharides can be thiolated via hydroxyl‐to‐thiol conversions or the covalent attachment of sulfhydryl ligands to hydroxyl, carbonic acid...
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Online Access: | http://dx.doi.org/10.1002/adfm.202310129 https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.202310129 |
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crwiley:10.1002/adfm.202310129 2024-06-02T08:05:13+00:00 Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing Noreen, Sobia Bernkop‐Schnürch, Andreas 2023 http://dx.doi.org/10.1002/adfm.202310129 https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.202310129 en eng Wiley http://creativecommons.org/licenses/by-nc/4.0/ Advanced Functional Materials volume 34, issue 4 ISSN 1616-301X 1616-3028 journal-article 2023 crwiley https://doi.org/10.1002/adfm.202310129 2024-05-03T10:45:42Z Abstract Due to thiolation of poly‐ and oligosaccharides numerous favorable properties for tissue engineering and wound healing can be introduced. Poly‐ and oligosaccharides can be thiolated via hydroxyl‐to‐thiol conversions or the covalent attachment of sulfhydryl ligands to hydroxyl, carbonic acid or amino groups on them. Since thiolated poly‐ and oligosaccharides can cross‐link via disulfide bonds, they form stable 3D networks with defined microarchitecture, stiffness, elasticity, and degradability. Furthermore, thiol groups can enhance cell adhesion since cells exhibit cysteine‐rich subdomains on their surface that form disulfide bonds with them. Sulfhydryl groups can also participate in cell signaling pathways favoring various cellular processes like proliferation, migration, spreading, and differentiation that are beneficial for tissue engineering and wound healing. In addition, a controlled release of active ingredients such as growth factors being bound via disulfide bonds to thiolated poly‐ and oligosaccharides can be achieved via thiol/disulfide exchange reactions. Over the last two decades, the number of thiolated poly‐ and oligosaccharides such as thiolated hyaluronic acid and thiolated chitosan used for tissue engineering and wound healing has increased tremendously. Within this review, an overview is provided about the chemistry of thiolated poly‐ and oligosaccharides, their key properties, applications and performance in clinical trials and as marketed products. Article in Journal/Newspaper Carbonic acid Wiley Online Library Advanced Functional Materials |
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Abstract Due to thiolation of poly‐ and oligosaccharides numerous favorable properties for tissue engineering and wound healing can be introduced. Poly‐ and oligosaccharides can be thiolated via hydroxyl‐to‐thiol conversions or the covalent attachment of sulfhydryl ligands to hydroxyl, carbonic acid or amino groups on them. Since thiolated poly‐ and oligosaccharides can cross‐link via disulfide bonds, they form stable 3D networks with defined microarchitecture, stiffness, elasticity, and degradability. Furthermore, thiol groups can enhance cell adhesion since cells exhibit cysteine‐rich subdomains on their surface that form disulfide bonds with them. Sulfhydryl groups can also participate in cell signaling pathways favoring various cellular processes like proliferation, migration, spreading, and differentiation that are beneficial for tissue engineering and wound healing. In addition, a controlled release of active ingredients such as growth factors being bound via disulfide bonds to thiolated poly‐ and oligosaccharides can be achieved via thiol/disulfide exchange reactions. Over the last two decades, the number of thiolated poly‐ and oligosaccharides such as thiolated hyaluronic acid and thiolated chitosan used for tissue engineering and wound healing has increased tremendously. Within this review, an overview is provided about the chemistry of thiolated poly‐ and oligosaccharides, their key properties, applications and performance in clinical trials and as marketed products. |
format |
Article in Journal/Newspaper |
author |
Noreen, Sobia Bernkop‐Schnürch, Andreas |
spellingShingle |
Noreen, Sobia Bernkop‐Schnürch, Andreas Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing |
author_facet |
Noreen, Sobia Bernkop‐Schnürch, Andreas |
author_sort |
Noreen, Sobia |
title |
Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing |
title_short |
Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing |
title_full |
Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing |
title_fullStr |
Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing |
title_full_unstemmed |
Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing |
title_sort |
thiolated poly‐ and oligosaccharide‐based hydrogels for tissue engineering and wound healing |
publisher |
Wiley |
publishDate |
2023 |
url |
http://dx.doi.org/10.1002/adfm.202310129 https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.202310129 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Advanced Functional Materials volume 34, issue 4 ISSN 1616-301X 1616-3028 |
op_rights |
http://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1002/adfm.202310129 |
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Advanced Functional Materials |
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