Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus
Objective To assess the impact of achieving Lupus Low Disease Activity State ≥50% of the time ( LLDAS ‐50) on damage accrual and mortality in an inception cohort of patients with systemic lupus erythematosus ( SLE ). Methods We used data from the Tromsø Lupus Cohort, a longitudinal population‐based...
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crwiley:10.1002/acr.23867 2024-06-23T07:57:14+00:00 Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus Sharma, Chanakya Raymond, Warren Eilertsen, Gro Nossent, Johannes 2020 http://dx.doi.org/10.1002/acr.23867 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Facr.23867 https://onlinelibrary.wiley.com/doi/pdf/10.1002/acr.23867 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acr.23867 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Arthritis Care & Research volume 72, issue 3, page 447-451 ISSN 2151-464X 2151-4658 journal-article 2020 crwiley https://doi.org/10.1002/acr.23867 2024-06-11T04:49:15Z Objective To assess the impact of achieving Lupus Low Disease Activity State ≥50% of the time ( LLDAS ‐50) on damage accrual and mortality in an inception cohort of patients with systemic lupus erythematosus ( SLE ). Methods We used data from the Tromsø Lupus Cohort, a longitudinal population‐based study of all patients with SLE in the 2 northernmost counties in Norway. LLDAS was defined as 1) a Systemic Lupus Erythematosus Disease Activity Index 2000 score of ≤4, with no activity in major organ systems, 2) no new features of lupus disease activity, 3) current therapy with prednisolone (or equivalent) dosage of ≤7.5 mg daily, and 4) well‐tolerated standard maintenance dosages of immunosuppressive drugs. Results A total of 69 patients (33.5%) spent at least half of their follow‐up time in LLDAS (thus, achieving LLDAS ‐50) and had significantly better survival and lower risk of developing severe damage over time, according to the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. After correcting for age and sex, LLDAS ‐50 was associated with a significant reduction in risk of having severe damage (hazard ratio [ HR ] 0.37 [95% confidence interval (95% CI ) 0.19–0.73], P < 0.01), and also a reduction in mortality ( HR 0.31 [95% CI 0.16–0.62], P < 0.01). Conclusion Our study validates the findings of the inception cohort by demonstrating that achievement of LLDAS ‐50 is associated with a significant reduction in severe damage and, for the first time, demonstrates a reduction in mortality. Article in Journal/Newspaper Tromsø Wiley Online Library Norway Tromsø Arthritis Care & Research 72 3 447 451 |
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English |
description |
Objective To assess the impact of achieving Lupus Low Disease Activity State ≥50% of the time ( LLDAS ‐50) on damage accrual and mortality in an inception cohort of patients with systemic lupus erythematosus ( SLE ). Methods We used data from the Tromsø Lupus Cohort, a longitudinal population‐based study of all patients with SLE in the 2 northernmost counties in Norway. LLDAS was defined as 1) a Systemic Lupus Erythematosus Disease Activity Index 2000 score of ≤4, with no activity in major organ systems, 2) no new features of lupus disease activity, 3) current therapy with prednisolone (or equivalent) dosage of ≤7.5 mg daily, and 4) well‐tolerated standard maintenance dosages of immunosuppressive drugs. Results A total of 69 patients (33.5%) spent at least half of their follow‐up time in LLDAS (thus, achieving LLDAS ‐50) and had significantly better survival and lower risk of developing severe damage over time, according to the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. After correcting for age and sex, LLDAS ‐50 was associated with a significant reduction in risk of having severe damage (hazard ratio [ HR ] 0.37 [95% confidence interval (95% CI ) 0.19–0.73], P < 0.01), and also a reduction in mortality ( HR 0.31 [95% CI 0.16–0.62], P < 0.01). Conclusion Our study validates the findings of the inception cohort by demonstrating that achievement of LLDAS ‐50 is associated with a significant reduction in severe damage and, for the first time, demonstrates a reduction in mortality. |
format |
Article in Journal/Newspaper |
author |
Sharma, Chanakya Raymond, Warren Eilertsen, Gro Nossent, Johannes |
spellingShingle |
Sharma, Chanakya Raymond, Warren Eilertsen, Gro Nossent, Johannes Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus |
author_facet |
Sharma, Chanakya Raymond, Warren Eilertsen, Gro Nossent, Johannes |
author_sort |
Sharma, Chanakya |
title |
Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus |
title_short |
Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus |
title_full |
Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus |
title_fullStr |
Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus |
title_full_unstemmed |
Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus |
title_sort |
association of achieving lupus low disease activity state fifty percent of the time with both reduced damage accrual and mortality in patients with systemic lupus erythematosus |
publisher |
Wiley |
publishDate |
2020 |
url |
http://dx.doi.org/10.1002/acr.23867 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Facr.23867 https://onlinelibrary.wiley.com/doi/pdf/10.1002/acr.23867 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acr.23867 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Arthritis Care & Research volume 72, issue 3, page 447-451 ISSN 2151-464X 2151-4658 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/acr.23867 |
container_title |
Arthritis Care & Research |
container_volume |
72 |
container_issue |
3 |
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447 |
op_container_end_page |
451 |
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1802650783780438016 |