The temperature and pH repertoire of the transglutaminase family is expanding
Transglutaminases (TGs) play important roles in the food industry, pharmacology, and biotechnology, but as protein cross‐linkers, their complexes are stable, resistant, immunogenic, and potentially pathogenic. Many TGs have been characterized, but they operate in narrow temperature and pH range limi...
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crwiley:10.1002/2211-5463.12839 2024-09-15T17:55:28+00:00 The temperature and pH repertoire of the transglutaminase family is expanding Lerner, Aaron Ramesh, Ajay Matthias, Torsten 2020 http://dx.doi.org/10.1002/2211-5463.12839 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F2211-5463.12839 https://onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12839 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/2211-5463.12839 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12839 en eng Wiley http://creativecommons.org/licenses/by/4.0/ FEBS Open Bio volume 10, issue 4, page 492-494 ISSN 2211-5463 2211-5463 journal-article 2020 crwiley https://doi.org/10.1002/2211-5463.12839 2024-07-23T04:12:33Z Transglutaminases (TGs) play important roles in the food industry, pharmacology, and biotechnology, but as protein cross‐linkers, their complexes are stable, resistant, immunogenic, and potentially pathogenic. Many TGs have been characterized, but they operate in narrow temperature and pH range limits. In a research article in this issue, Clemens Furnes and colleagues describe a novel cold‐adapted TG from Atlantic cod, which expands the operating boundaries to a lower temperature and a wider pH. In this accompanying commentary, we discuss how this TG opens new applications in cold environments and can be deactivated by heating. New sources of TGs should be explored in hot environments like hot springs, in order to increase the temperature and widen the pH ranges for human and industrial benefits. Article in Journal/Newspaper atlantic cod Wiley Online Library FEBS Open Bio 10 4 492 494 |
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Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Transglutaminases (TGs) play important roles in the food industry, pharmacology, and biotechnology, but as protein cross‐linkers, their complexes are stable, resistant, immunogenic, and potentially pathogenic. Many TGs have been characterized, but they operate in narrow temperature and pH range limits. In a research article in this issue, Clemens Furnes and colleagues describe a novel cold‐adapted TG from Atlantic cod, which expands the operating boundaries to a lower temperature and a wider pH. In this accompanying commentary, we discuss how this TG opens new applications in cold environments and can be deactivated by heating. New sources of TGs should be explored in hot environments like hot springs, in order to increase the temperature and widen the pH ranges for human and industrial benefits. |
format |
Article in Journal/Newspaper |
author |
Lerner, Aaron Ramesh, Ajay Matthias, Torsten |
spellingShingle |
Lerner, Aaron Ramesh, Ajay Matthias, Torsten The temperature and pH repertoire of the transglutaminase family is expanding |
author_facet |
Lerner, Aaron Ramesh, Ajay Matthias, Torsten |
author_sort |
Lerner, Aaron |
title |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_short |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_full |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_fullStr |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_full_unstemmed |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_sort |
temperature and ph repertoire of the transglutaminase family is expanding |
publisher |
Wiley |
publishDate |
2020 |
url |
http://dx.doi.org/10.1002/2211-5463.12839 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F2211-5463.12839 https://onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12839 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/2211-5463.12839 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12839 |
genre |
atlantic cod |
genre_facet |
atlantic cod |
op_source |
FEBS Open Bio volume 10, issue 4, page 492-494 ISSN 2211-5463 2211-5463 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1002/2211-5463.12839 |
container_title |
FEBS Open Bio |
container_volume |
10 |
container_issue |
4 |
container_start_page |
492 |
op_container_end_page |
494 |
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1810431757630046208 |