Esters of Mono‐ and Alkenyl Carboxylic Acids and Mono‐ and Polyalcohols

• Main Authors: Coleman, Kelly P., Toscano, William A.
• Format: Other/Unknown Material
• Language: English
• Published: Wiley 2012
• Subjects: Carbonic acid
• Online Access: http://dx.doi.org/10.1002/0471435139.tox079.pub2; https://onlinelibrary.wiley.com/doi/pdf/10.1002/0471435139.tox079.pub2

Abstract This volume contains three chapters reviewing 12 classes of organic compounds called esters . This chapter (Chapter 57) reviews esters of monocarboxylic acids and mono‐ and polyalcohols and esters of alkenyl carboxylic acids and monoalcohols; Chapter 58 reviews esters of aromatic monocarboxylic acids and monoalcohols, esters of monocarboxylic acids and di‐, tri‐, and polyalcohols, dicarboxylic acid esters, alkenyl dicarboxylic esters, esters of aromatic diacids, and tricarboxylic acid esters; and Chapter 59 covers esters of carbonic acid and orthocarbonic acid, esters of organic phosphorous compounds, esters of monocarboxylic halogenated acids, alkanols, or haloalcohols, and organic silicon esters. The sequence of the compounds has been organized according to the chemical structure of the major functional metabolites. This involves the ester hydrolyzates, primarily the acid and secondarily the alcohol. The reason for this sequence was the general observation that the degree of toxic effect, in addition to that of the original material, more often was the result of the toxicity of the acid rather than the response of the alcohol. Esters are important from an industrial hygiene perspective since exposure can occur during the process of manufacturing esters, the process of manufacturing materials containing or composed of esters, handling and use of products containing or composed of esters, and treatment of wastes containing esters. In turn, exposure to esters is important from a toxicological perspective because of the correlated observations of adverse physiological responses exhibited by laboratory animals and humans. Overviews of the physical, chemical, and toxicological (i.e., physiological responses) properties of many subclasses of esters and/or of specific compounds are provided. In addition, summaries of relative manufacturing and use information are included for many compounds. Chemically, esters are organic compounds commonly formed via the combination of an acid, typically an organic (COOH) ...