Medicinal Chemistry Approaches for Multitarget Drugs
Abstract It has become increasingly well recognized that modulating multiple biological targets in parallel can be beneficial for treating diseases with complex etiologies such as cancer, asthma, and psychiatric diseases. Both screening and knowledge‐based strategies have been used for generating li...
Main Authors: | , |
---|---|
Format: | Other/Unknown Material |
Language: | English |
Published: |
Wiley
2010
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1002/0471266949.bmc124 https://onlinelibrary.wiley.com/doi/pdf/10.1002/0471266949.bmc124 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/0471266949.bmc124 |
id |
crwiley:10.1002/0471266949.bmc124 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1002/0471266949.bmc124 2024-09-30T14:34:09+00:00 Medicinal Chemistry Approaches for Multitarget Drugs Morphy, Richard Rankovic, Zoran 2010 http://dx.doi.org/10.1002/0471266949.bmc124 https://onlinelibrary.wiley.com/doi/pdf/10.1002/0471266949.bmc124 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/0471266949.bmc124 en eng Wiley http://doi.wiley.com/10.1002/tdm_license_1.1 http://doi.wiley.com/10.1002/tdm_license_1.1 Burger's Medicinal Chemistry and Drug Discovery page 249-274 ISBN 9780471266945 other 2010 crwiley https://doi.org/10.1002/0471266949.bmc124 2024-09-05T05:04:56Z Abstract It has become increasingly well recognized that modulating multiple biological targets in parallel can be beneficial for treating diseases with complex etiologies such as cancer, asthma, and psychiatric diseases. Both screening and knowledge‐based strategies have been used for generating ligands with a specific multitarget profile (designed multiple ligands or DMLs). DML projects are often challenging for medicinal chemists, with the need to appropriately balance affinity for two or more targets while obtaining physicochemical and pharmacokinetic properties that are consistent with the administration of an oral drug. The physicochemical properties of DMLs are influenced to a large extent by the proteomic superfamily to which the targets belong and the lead generation strategy that is pursued. Since DML projects are resource hungry, an early assessment of the feasibility of any given DML project is essential. Other/Unknown Material DML Wiley Online Library 249 274 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Abstract It has become increasingly well recognized that modulating multiple biological targets in parallel can be beneficial for treating diseases with complex etiologies such as cancer, asthma, and psychiatric diseases. Both screening and knowledge‐based strategies have been used for generating ligands with a specific multitarget profile (designed multiple ligands or DMLs). DML projects are often challenging for medicinal chemists, with the need to appropriately balance affinity for two or more targets while obtaining physicochemical and pharmacokinetic properties that are consistent with the administration of an oral drug. The physicochemical properties of DMLs are influenced to a large extent by the proteomic superfamily to which the targets belong and the lead generation strategy that is pursued. Since DML projects are resource hungry, an early assessment of the feasibility of any given DML project is essential. |
format |
Other/Unknown Material |
author |
Morphy, Richard Rankovic, Zoran |
spellingShingle |
Morphy, Richard Rankovic, Zoran Medicinal Chemistry Approaches for Multitarget Drugs |
author_facet |
Morphy, Richard Rankovic, Zoran |
author_sort |
Morphy, Richard |
title |
Medicinal Chemistry Approaches for Multitarget Drugs |
title_short |
Medicinal Chemistry Approaches for Multitarget Drugs |
title_full |
Medicinal Chemistry Approaches for Multitarget Drugs |
title_fullStr |
Medicinal Chemistry Approaches for Multitarget Drugs |
title_full_unstemmed |
Medicinal Chemistry Approaches for Multitarget Drugs |
title_sort |
medicinal chemistry approaches for multitarget drugs |
publisher |
Wiley |
publishDate |
2010 |
url |
http://dx.doi.org/10.1002/0471266949.bmc124 https://onlinelibrary.wiley.com/doi/pdf/10.1002/0471266949.bmc124 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/0471266949.bmc124 |
genre |
DML |
genre_facet |
DML |
op_source |
Burger's Medicinal Chemistry and Drug Discovery page 249-274 ISBN 9780471266945 |
op_rights |
http://doi.wiley.com/10.1002/tdm_license_1.1 http://doi.wiley.com/10.1002/tdm_license_1.1 |
op_doi |
https://doi.org/10.1002/0471266949.bmc124 |
container_start_page |
249 |
op_container_end_page |
274 |
_version_ |
1811637838876246016 |