The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromsø Study
Background Obesity is a well-established risk factor for venous thromboembolism (VTE). However, data on the proportion of incident VTEs attributed to overweight and obesity in the general population are limited. Objective To investigate the population attributable fraction (PAF) of VTE due to overwe...
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Georg Thieme Verlag KG
2023
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crthieme:10.1055/s-0043-1772212 2024-05-19T07:49:32+00:00 The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromsø Study Frischmuth, Tobias Tøndel, Birgitte G. Brækkan, Sigrid K. Hansen, John-Bjarne Morelli, Vânia M. 2023 http://dx.doi.org/10.1055/s-0043-1772212 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-1772212.pdf en eng Georg Thieme Verlag KG Thrombosis and Haemostasis volume 124, issue 03, page 239-249 ISSN 0340-6245 2567-689X journal-article 2023 crthieme https://doi.org/10.1055/s-0043-1772212 2024-05-01T07:18:02Z Background Obesity is a well-established risk factor for venous thromboembolism (VTE). However, data on the proportion of incident VTEs attributed to overweight and obesity in the general population are limited. Objective To investigate the population attributable fraction (PAF) of VTE due to overweight and obesity in a population-based cohort with repeated measurements of body mass index (BMI). Methods Participants from the fourth to seventh surveys of the Tromsø Study (enrolment: 1994–2016) were followed through 2020, and all incident VTEs were recorded. In total, 36,341 unique participants were included, and BMI measurements were updated for those attending more than one survey. BMI was categorized as <25 kg/m2, 25–30 kg/m2 (overweight), and ≥30 kg/m2 (obesity). Time-varying Cox regression models were used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). The PAF was estimated based on age- and sex-adjusted HRs and the prevalence of BMI categories in VTE cases. Results At baseline, the prevalence of overweight and obesity was 37.9 and 13.8%, respectively. During a median follow-up of 13.9 years, 1,051 VTEs occurred. The age- and sex-adjusted HRs of VTE were 1.40 (95% CI: 1.21–1.61) for overweight and 1.86 (95% CI: 1.58–2.20) for obesity compared with subjects with BMI <25 kg/m2. The PAF of VTE due to overweight and obesity was 24.6% (95% CI: 16.6–32.9), with 12.9% (95% CI: 6.6–19.0) being attributed to overweight and 11.7% (95% CI: 8.5–14.9) to obesity. Similar PAFs were obtained in analyses stratified by sex and VTE subtypes (provoked/unprovoked events, deep vein thrombosis, pulmonary embolism). Conclusion Our findings indicate that almost 25% of all VTE events can be attributed to overweight and obesity in a general population from Norway. Article in Journal/Newspaper Tromsø Thieme Thrombosis and Haemostasis |
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English |
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Background Obesity is a well-established risk factor for venous thromboembolism (VTE). However, data on the proportion of incident VTEs attributed to overweight and obesity in the general population are limited. Objective To investigate the population attributable fraction (PAF) of VTE due to overweight and obesity in a population-based cohort with repeated measurements of body mass index (BMI). Methods Participants from the fourth to seventh surveys of the Tromsø Study (enrolment: 1994–2016) were followed through 2020, and all incident VTEs were recorded. In total, 36,341 unique participants were included, and BMI measurements were updated for those attending more than one survey. BMI was categorized as <25 kg/m2, 25–30 kg/m2 (overweight), and ≥30 kg/m2 (obesity). Time-varying Cox regression models were used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). The PAF was estimated based on age- and sex-adjusted HRs and the prevalence of BMI categories in VTE cases. Results At baseline, the prevalence of overweight and obesity was 37.9 and 13.8%, respectively. During a median follow-up of 13.9 years, 1,051 VTEs occurred. The age- and sex-adjusted HRs of VTE were 1.40 (95% CI: 1.21–1.61) for overweight and 1.86 (95% CI: 1.58–2.20) for obesity compared with subjects with BMI <25 kg/m2. The PAF of VTE due to overweight and obesity was 24.6% (95% CI: 16.6–32.9), with 12.9% (95% CI: 6.6–19.0) being attributed to overweight and 11.7% (95% CI: 8.5–14.9) to obesity. Similar PAFs were obtained in analyses stratified by sex and VTE subtypes (provoked/unprovoked events, deep vein thrombosis, pulmonary embolism). Conclusion Our findings indicate that almost 25% of all VTE events can be attributed to overweight and obesity in a general population from Norway. |
format |
Article in Journal/Newspaper |
author |
Frischmuth, Tobias Tøndel, Birgitte G. Brækkan, Sigrid K. Hansen, John-Bjarne Morelli, Vânia M. |
spellingShingle |
Frischmuth, Tobias Tøndel, Birgitte G. Brækkan, Sigrid K. Hansen, John-Bjarne Morelli, Vânia M. The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromsø Study |
author_facet |
Frischmuth, Tobias Tøndel, Birgitte G. Brækkan, Sigrid K. Hansen, John-Bjarne Morelli, Vânia M. |
author_sort |
Frischmuth, Tobias |
title |
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromsø Study |
title_short |
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromsø Study |
title_full |
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromsø Study |
title_fullStr |
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromsø Study |
title_full_unstemmed |
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromsø Study |
title_sort |
risk of incident venous thromboembolism attributed to overweight and obesity: the tromsø study |
publisher |
Georg Thieme Verlag KG |
publishDate |
2023 |
url |
http://dx.doi.org/10.1055/s-0043-1772212 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-1772212.pdf |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Thrombosis and Haemostasis volume 124, issue 03, page 239-249 ISSN 0340-6245 2567-689X |
op_doi |
https://doi.org/10.1055/s-0043-1772212 |
container_title |
Thrombosis and Haemostasis |
_version_ |
1799468045419151360 |