Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism
Abstract Background Circulating levels of leptin, an adipocyte-derived hormone, are frequently elevated in obesity. Leptin has been reported to upregulate prothrombotic hemostatic factors in vitro and could potentially mediate venous thromboembolism (VTE) risk in obesity. However, whether leptin is...
Published in: | Thrombosis and Haemostasis |
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Georg Thieme Verlag KG
2021
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Online Access: | http://dx.doi.org/10.1055/s-0041-1732295 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0041-1732295.pdf |
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crthieme:10.1055/s-0041-1732295 2024-05-19T07:49:33+00:00 Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism Frischmuth, Tobias Hindberg, Kristian Aukrust, Pål Ueland, Thor Brækkan, Sigrid K. Hansen, John-Bjarne Morelli, Vânia M. Stiftelsen Kristian Gerhard Jebsen Northern Norway Regional Health Authority 2021 http://dx.doi.org/10.1055/s-0041-1732295 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0041-1732295.pdf en eng Georg Thieme Verlag KG Thrombosis and Haemostasis volume 122, issue 04, page 560-569 ISSN 0340-6245 2567-689X journal-article 2021 crthieme https://doi.org/10.1055/s-0041-1732295 2024-05-01T07:17:04Z Abstract Background Circulating levels of leptin, an adipocyte-derived hormone, are frequently elevated in obesity. Leptin has been reported to upregulate prothrombotic hemostatic factors in vitro and could potentially mediate venous thromboembolism (VTE) risk in obesity. However, whether leptin is associated with VTE remains uncertain. Objective This article investigates the association between plasma leptin and risk of incident VTE, and the potential of leptin to mediate VTE risk in obesity. Methods A population-based nested case–control study with 416 VTE cases and 848 age- and sex-matched controls was derived from the Tromsø Study. Logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for VTE across leptin quartiles. Analyses were performed separately in men and women using sex-specific quartile cut-offs determined in controls. Results In the age-adjusted model, the VTE risk increased across leptin quartiles, particularly in men. Compared with the lowest quartile, the ORs for VTE in the highest quartile were 1.70 (95% CI 1.04–2.79) in men and 1.36 (95% CI 0.85–2.17) in women. However, with additional adjustment for body mass index (BMI), risk estimates were markedly attenuated in men (OR 1.03, 95% CI 0.55–1.93) and women (OR 0.82, 95% CI 0.45–1.48). The ORs for VTE were increased in obese men and women (BMI ≥ 30 kg/m2) and were only marginally affected after adjustment for leptin. Conclusion Our results indicate that the apparent association between plasma leptin levels and VTE risk is confounded by BMI and that leptin is not a relevant mediator for VTE risk in obesity. Article in Journal/Newspaper Tromsø Thieme Thrombosis and Haemostasis |
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Abstract Background Circulating levels of leptin, an adipocyte-derived hormone, are frequently elevated in obesity. Leptin has been reported to upregulate prothrombotic hemostatic factors in vitro and could potentially mediate venous thromboembolism (VTE) risk in obesity. However, whether leptin is associated with VTE remains uncertain. Objective This article investigates the association between plasma leptin and risk of incident VTE, and the potential of leptin to mediate VTE risk in obesity. Methods A population-based nested case–control study with 416 VTE cases and 848 age- and sex-matched controls was derived from the Tromsø Study. Logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for VTE across leptin quartiles. Analyses were performed separately in men and women using sex-specific quartile cut-offs determined in controls. Results In the age-adjusted model, the VTE risk increased across leptin quartiles, particularly in men. Compared with the lowest quartile, the ORs for VTE in the highest quartile were 1.70 (95% CI 1.04–2.79) in men and 1.36 (95% CI 0.85–2.17) in women. However, with additional adjustment for body mass index (BMI), risk estimates were markedly attenuated in men (OR 1.03, 95% CI 0.55–1.93) and women (OR 0.82, 95% CI 0.45–1.48). The ORs for VTE were increased in obese men and women (BMI ≥ 30 kg/m2) and were only marginally affected after adjustment for leptin. Conclusion Our results indicate that the apparent association between plasma leptin levels and VTE risk is confounded by BMI and that leptin is not a relevant mediator for VTE risk in obesity. |
author2 |
Stiftelsen Kristian Gerhard Jebsen Northern Norway Regional Health Authority |
format |
Article in Journal/Newspaper |
author |
Frischmuth, Tobias Hindberg, Kristian Aukrust, Pål Ueland, Thor Brækkan, Sigrid K. Hansen, John-Bjarne Morelli, Vânia M. |
spellingShingle |
Frischmuth, Tobias Hindberg, Kristian Aukrust, Pål Ueland, Thor Brækkan, Sigrid K. Hansen, John-Bjarne Morelli, Vânia M. Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism |
author_facet |
Frischmuth, Tobias Hindberg, Kristian Aukrust, Pål Ueland, Thor Brækkan, Sigrid K. Hansen, John-Bjarne Morelli, Vânia M. |
author_sort |
Frischmuth, Tobias |
title |
Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism |
title_short |
Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism |
title_full |
Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism |
title_fullStr |
Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism |
title_full_unstemmed |
Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism |
title_sort |
plasma levels of leptin and risk of future incident venous thromboembolism |
publisher |
Georg Thieme Verlag KG |
publishDate |
2021 |
url |
http://dx.doi.org/10.1055/s-0041-1732295 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0041-1732295.pdf |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Thrombosis and Haemostasis volume 122, issue 04, page 560-569 ISSN 0340-6245 2567-689X |
op_doi |
https://doi.org/10.1055/s-0041-1732295 |
container_title |
Thrombosis and Haemostasis |
_version_ |
1799468061186588672 |