Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study
Abstract Introduction Red cell distribution width (RDW) is associated with cardiovascular diseases, including atrial fibrillation (AF) and venous thromboembolism (VTE). Whether RDW is a risk marker for thromboembolic events in AF patients is scarcely known. We aimed to assess the association between...
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Georg Thieme Verlag KG
2020
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Online Access: | http://dx.doi.org/10.1055/s-0040-1716417 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1716417.pdf |
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crthieme:10.1055/s-0040-1716417 2024-09-09T20:12:02+00:00 Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study Hald, Erin M. Løchen, Maja-Lisa Lappegård, Jostein Ellingsen, Trygve S. Mathiesen, Ellisiv B. Wilsgaard, Tom Njølstad, Inger Brækkan, Sigrid K. Hansen, John-Bjarne K.G. Jebsen Foundation Northern Norway Regional Health Authority 2020 http://dx.doi.org/10.1055/s-0040-1716417 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1716417.pdf en eng Georg Thieme Verlag KG https://creativecommons.org/licenses/by/4.0/ TH Open volume 04, issue 03, page e280-e287 ISSN 2512-9465 journal-article 2020 crthieme https://doi.org/10.1055/s-0040-1716417 2024-08-12T04:52:20Z Abstract Introduction Red cell distribution width (RDW) is associated with cardiovascular diseases, including atrial fibrillation (AF) and venous thromboembolism (VTE). Whether RDW is a risk marker for thromboembolic events in AF patients is scarcely known. We aimed to assess the association between RDW and the risk of AF, and AF-related VTE and ischemic stroke, in a population-based cohort. Methods We measured RDW in 26,111 participants from the Tromsø Study (1994–1995), and registered incident AF cases through December 31, 2013. Among participants with AF, first-ever VTEs and ischemic strokes were registered from the date of AF diagnosis through the end of follow-up. We calculated hazard ratios (HRs) with 95% confidence intervals (CIs) for AF by quartiles of RDW. Furthermore, we calculated cause-specific HRs for VTE and ischemic stroke by tertiles of RDW for participants with AF. Results There were 2,081 incident AF cases during a median of 18.8 years of follow-up. Subjects with RDW in the highest quartile (RDW ≥ 13.3%) had 30% higher risk of AF than those in the lowest quartile (RDW ≤ 12.3%). Among those with AF, subjects with RDW in the upper tertile had a doubled risk of ischemic stroke (HR 2.07, 95% CI 1.20–3.57). In contrast, RDW was not associated with incident VTE in subjects with AF. Conclusion RDW was significantly associated with incident AF in a general population. Among subjects with AF, high RDW was associated with ischemic stroke, but not VTE. Article in Journal/Newspaper Tromsø Thieme Tromsø TH Open 04 03 e280 e287 |
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English |
description |
Abstract Introduction Red cell distribution width (RDW) is associated with cardiovascular diseases, including atrial fibrillation (AF) and venous thromboembolism (VTE). Whether RDW is a risk marker for thromboembolic events in AF patients is scarcely known. We aimed to assess the association between RDW and the risk of AF, and AF-related VTE and ischemic stroke, in a population-based cohort. Methods We measured RDW in 26,111 participants from the Tromsø Study (1994–1995), and registered incident AF cases through December 31, 2013. Among participants with AF, first-ever VTEs and ischemic strokes were registered from the date of AF diagnosis through the end of follow-up. We calculated hazard ratios (HRs) with 95% confidence intervals (CIs) for AF by quartiles of RDW. Furthermore, we calculated cause-specific HRs for VTE and ischemic stroke by tertiles of RDW for participants with AF. Results There were 2,081 incident AF cases during a median of 18.8 years of follow-up. Subjects with RDW in the highest quartile (RDW ≥ 13.3%) had 30% higher risk of AF than those in the lowest quartile (RDW ≤ 12.3%). Among those with AF, subjects with RDW in the upper tertile had a doubled risk of ischemic stroke (HR 2.07, 95% CI 1.20–3.57). In contrast, RDW was not associated with incident VTE in subjects with AF. Conclusion RDW was significantly associated with incident AF in a general population. Among subjects with AF, high RDW was associated with ischemic stroke, but not VTE. |
author2 |
K.G. Jebsen Foundation Northern Norway Regional Health Authority |
format |
Article in Journal/Newspaper |
author |
Hald, Erin M. Løchen, Maja-Lisa Lappegård, Jostein Ellingsen, Trygve S. Mathiesen, Ellisiv B. Wilsgaard, Tom Njølstad, Inger Brækkan, Sigrid K. Hansen, John-Bjarne |
spellingShingle |
Hald, Erin M. Løchen, Maja-Lisa Lappegård, Jostein Ellingsen, Trygve S. Mathiesen, Ellisiv B. Wilsgaard, Tom Njølstad, Inger Brækkan, Sigrid K. Hansen, John-Bjarne Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
author_facet |
Hald, Erin M. Løchen, Maja-Lisa Lappegård, Jostein Ellingsen, Trygve S. Mathiesen, Ellisiv B. Wilsgaard, Tom Njølstad, Inger Brækkan, Sigrid K. Hansen, John-Bjarne |
author_sort |
Hald, Erin M. |
title |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_short |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_full |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_fullStr |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_full_unstemmed |
Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study |
title_sort |
red cell distribution width and risk of atrial fibrillation and subsequent thromboembolism: the tromsø study |
publisher |
Georg Thieme Verlag KG |
publishDate |
2020 |
url |
http://dx.doi.org/10.1055/s-0040-1716417 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1716417.pdf |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
TH Open volume 04, issue 03, page e280-e287 ISSN 2512-9465 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1055/s-0040-1716417 |
container_title |
TH Open |
container_volume |
04 |
container_issue |
03 |
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e280 |
op_container_end_page |
e287 |
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1809946628706009088 |