Complement C3 Polymorphism In Greenland Eskimos

• Published in: Thrombosis and Haemostasis, Oral Presentations
• Main Authors: Jørqensen, K A, Dyerberq, J, Stoffersen, E, Nymand, G
• Format: Conference Object
• Language: unknown
• Published: Schattauer GmbH 1981
• Subjects: eskimo*; Greenland
• Online Access: http://dx.doi.org/10.1055/s-0038-1652720; http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1652720.pdf

The C3F gene has been associated with atherosclerotic vascular disease. Greenland Eskimos have a very low frequency of acute myocardial infarction (AMI). The C3 polymorphism phenotypes were therefore determined by high-voltage agarose gel electrophoresis in 125 Greenland Eskimos originating from different parts of Greenland and compared with a control group of 1,554 Caucasian Danes. p The C3F gene frequency in the Eskimos (0.056) was significantly lower (p <0.001) than in the control Danes (0.201). These results indicate that genetical factors may also play a role for the low AMI frequency seen in Greenland Eskimos.