Intra- and Interindividual Variability of Hemostatic Factors and Traditional Cardiovascular Risk Factors in a Three-year Follow-up
Summary Elucidation of the key role of thrombosis in cardiovascular disease events has arisen considerable interest in hemostatic factors and in the repeatability of their determinations. Data on long-term repeatability has, however, remained scanty. We examined twice 208 men and 265 women in North...
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Georg Thieme Verlag KG
1998
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crthieme:10.1055/s-0037-1615104 2024-05-19T07:43:20+00:00 Intra- and Interindividual Variability of Hemostatic Factors and Traditional Cardiovascular Risk Factors in a Three-year Follow-up Salomaa, Veikko Rasi, Vesa Stengård, Jari Vahtera, Elina Pekkanen, Juha Vartiainen, Erkki Ehnholm, Christian Puska, Pekka 1998 http://dx.doi.org/10.1055/s-0037-1615104 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1615104.pdf en eng Georg Thieme Verlag KG Thrombosis and Haemostasis volume 79, issue 05, page 969-974 ISSN 0340-6245 2567-689X journal-article 1998 crthieme https://doi.org/10.1055/s-0037-1615104 2024-05-01T07:16:06Z Summary Elucidation of the key role of thrombosis in cardiovascular disease events has arisen considerable interest in hemostatic factors and in the repeatability of their determinations. Data on long-term repeatability has, however, remained scanty. We examined twice 208 men and 265 women in North Karelia, eastern Finland. The baseline examination was a part of the FINRISK 1992 Hemostasis Study and the age-range of participants was between 45-64 years. The re-examination took place three years later in 1995. Both surveys followed the same protocol and were carried out during the same season. Spearman rank correlation coefficients between 1992 and 1995 measurements of fibrinogen, factor VII coagulant activity (FVII:C), factor VII antigen (FVII:Ag), and plasminogen were among men 0.72, 0.77, 0.46 and 0.56, respectively. For total cholesterol, HDL-cholesterol, triglycerides and diastolic blood pressure the corresponding coefficients were 0.74, 0.83, 0.66, and 0.54. In women, the coefficient of fibrinogen was lower than in men, 0.62, otherwise the results were similar. Of men belonging to the highest quarter of fibrinogen, FVII:C, FVII:Ag and plasminogen in 1992, 65%, 60%, 53% and 60% belonged to the highest quarter of respective distributions also in 1995. In women, the corresponding proportions were 64%, 65%, 46% and 58%. The modest repeatability of FVII:Ag and plasminogen was mainly due to the high intraindividual variability. However, in comparisons of plasma levels between two groups, relatively small sample sizes seemed to give adequate statistical power to detect possible differences in FVII:Ag and plasminogen. In conclusion, the long-term repeatability of fibrinogen and FVII:C is similar to that of triglycerides and even better than that of diastolic blood pressure, but somewhat lower than the repeatability of total cholesterol. FVII:Ag and plasminogen did not have very good repeatability and more than one measurement of them should be considered if they are used as predictors of cardiovascular disease in ... Article in Journal/Newspaper karelia* Thieme Thrombosis and Haemostasis 79 05 969 974 |
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English |
description |
Summary Elucidation of the key role of thrombosis in cardiovascular disease events has arisen considerable interest in hemostatic factors and in the repeatability of their determinations. Data on long-term repeatability has, however, remained scanty. We examined twice 208 men and 265 women in North Karelia, eastern Finland. The baseline examination was a part of the FINRISK 1992 Hemostasis Study and the age-range of participants was between 45-64 years. The re-examination took place three years later in 1995. Both surveys followed the same protocol and were carried out during the same season. Spearman rank correlation coefficients between 1992 and 1995 measurements of fibrinogen, factor VII coagulant activity (FVII:C), factor VII antigen (FVII:Ag), and plasminogen were among men 0.72, 0.77, 0.46 and 0.56, respectively. For total cholesterol, HDL-cholesterol, triglycerides and diastolic blood pressure the corresponding coefficients were 0.74, 0.83, 0.66, and 0.54. In women, the coefficient of fibrinogen was lower than in men, 0.62, otherwise the results were similar. Of men belonging to the highest quarter of fibrinogen, FVII:C, FVII:Ag and plasminogen in 1992, 65%, 60%, 53% and 60% belonged to the highest quarter of respective distributions also in 1995. In women, the corresponding proportions were 64%, 65%, 46% and 58%. The modest repeatability of FVII:Ag and plasminogen was mainly due to the high intraindividual variability. However, in comparisons of plasma levels between two groups, relatively small sample sizes seemed to give adequate statistical power to detect possible differences in FVII:Ag and plasminogen. In conclusion, the long-term repeatability of fibrinogen and FVII:C is similar to that of triglycerides and even better than that of diastolic blood pressure, but somewhat lower than the repeatability of total cholesterol. FVII:Ag and plasminogen did not have very good repeatability and more than one measurement of them should be considered if they are used as predictors of cardiovascular disease in ... |
format |
Article in Journal/Newspaper |
author |
Salomaa, Veikko Rasi, Vesa Stengård, Jari Vahtera, Elina Pekkanen, Juha Vartiainen, Erkki Ehnholm, Christian Puska, Pekka |
spellingShingle |
Salomaa, Veikko Rasi, Vesa Stengård, Jari Vahtera, Elina Pekkanen, Juha Vartiainen, Erkki Ehnholm, Christian Puska, Pekka Intra- and Interindividual Variability of Hemostatic Factors and Traditional Cardiovascular Risk Factors in a Three-year Follow-up |
author_facet |
Salomaa, Veikko Rasi, Vesa Stengård, Jari Vahtera, Elina Pekkanen, Juha Vartiainen, Erkki Ehnholm, Christian Puska, Pekka |
author_sort |
Salomaa, Veikko |
title |
Intra- and Interindividual Variability of Hemostatic Factors and Traditional Cardiovascular Risk Factors in a Three-year Follow-up |
title_short |
Intra- and Interindividual Variability of Hemostatic Factors and Traditional Cardiovascular Risk Factors in a Three-year Follow-up |
title_full |
Intra- and Interindividual Variability of Hemostatic Factors and Traditional Cardiovascular Risk Factors in a Three-year Follow-up |
title_fullStr |
Intra- and Interindividual Variability of Hemostatic Factors and Traditional Cardiovascular Risk Factors in a Three-year Follow-up |
title_full_unstemmed |
Intra- and Interindividual Variability of Hemostatic Factors and Traditional Cardiovascular Risk Factors in a Three-year Follow-up |
title_sort |
intra- and interindividual variability of hemostatic factors and traditional cardiovascular risk factors in a three-year follow-up |
publisher |
Georg Thieme Verlag KG |
publishDate |
1998 |
url |
http://dx.doi.org/10.1055/s-0037-1615104 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1615104.pdf |
genre |
karelia* |
genre_facet |
karelia* |
op_source |
Thrombosis and Haemostasis volume 79, issue 05, page 969-974 ISSN 0340-6245 2567-689X |
op_doi |
https://doi.org/10.1055/s-0037-1615104 |
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Thrombosis and Haemostasis |
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79 |
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05 |
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969 |
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974 |
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