Clinical and neurophysiological correlation in axonal and demyelinating polyneuropathy
Abstract Background The neurophysiological examination provides valuable pathophysiological information for the diagnosis, prognosis, and therapy of patients with polyneuropathy (Fuglsang- Fredriksen A., Pugdahl K. Clin Neurophysilogy 122:440–455, 2011). Nerve conduction study (NCS) is the most obje...
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crspringernat:10.1186/s42269-020-00352-6 2023-05-15T16:02:06+02:00 Clinical and neurophysiological correlation in axonal and demyelinating polyneuropathy Hewedi, Kamel Mahmoud Ali Monzer, Mahmoud Abdelmoety Sobh, Khaled Mohammad Aboelmakarem, Mohammad Abdelhady M. Mohammady, Amir Abdelghaffar Hasan, Mahmoud Mohamad Abdulsalam, Mohammad Fathi Helal, Suzette Ibrahim Ibrahim Ibrahim 2020 http://dx.doi.org/10.1186/s42269-020-00352-6 https://link.springer.com/content/pdf/10.1186/s42269-020-00352-6.pdf https://link.springer.com/article/10.1186/s42269-020-00352-6/fulltext.html en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Bulletin of the National Research Centre volume 44, issue 1 ISSN 2522-8307 General Medicine journal-article 2020 crspringernat https://doi.org/10.1186/s42269-020-00352-6 2022-01-04T07:23:22Z Abstract Background The neurophysiological examination provides valuable pathophysiological information for the diagnosis, prognosis, and therapy of patients with polyneuropathy (Fuglsang- Fredriksen A., Pugdahl K. Clin Neurophysilogy 122:440–455, 2011). Nerve conduction study (NCS) is the most objective and reliable measure of peripheral nerve function and is considered the gold standard for the diagnosis of most neuropathies . Aim of the study To evaluate the clinical usefulness of nerve conduction study (NCS) in the differentiation between axonal and demyelinating polyneuropathies. Methods In the present study, 125 patients with polyneuropathy were studied ranging age from 9 to 79 years. Thirty-six patients were classified as axonal polyneuropathy, 23 patients as demyelinating, and 9 as mixed, while 57 patients were classified as neuropathic. Nerve conduction study (NCS) and electromyography (EMG) were performed using Nihon Kochden electromyography machine with surface recording and stimulating electrodes . Results There is statistically significant linear correlation between reduction in sensory nerve action potential (SNAP) amplitude and decrease in sensory conduction velocity (SCV) of median and ulnar nerves. Also, there is statistically significant inverse correlation between reduction in compound motor action potential (CMAP) amplitude and increase in distal motor latency (DML). There is statistically significant linear correlation between reduction in compound motor action potential (CMAP) amplitude and decrease in motor conduction velocity (MCV). There is statistically significant linear correlation between reduction in compound motor action potential (CMAP) amplitude and decreased grade of power in both axonal and demyelinating polyneuropathy; statistically significant linear correlation was found between decrease in conduction velocity and decrease in grade of power. Conclusion The present study demonstrates significant correlation between amplitude reduction and conduction slowing in demyelinating as well as axonal polyneuropathy. Article in Journal/Newspaper DML Springer Nature (via Crossref) Fredriksen ENVELOPE(-45.000,-45.000,-60.733,-60.733) Bulletin of the National Research Centre 44 1 |
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Springer Nature (via Crossref) |
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English |
topic |
General Medicine |
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General Medicine Hewedi, Kamel Mahmoud Ali Monzer, Mahmoud Abdelmoety Sobh, Khaled Mohammad Aboelmakarem, Mohammad Abdelhady M. Mohammady, Amir Abdelghaffar Hasan, Mahmoud Mohamad Abdulsalam, Mohammad Fathi Helal, Suzette Ibrahim Ibrahim Ibrahim Clinical and neurophysiological correlation in axonal and demyelinating polyneuropathy |
topic_facet |
General Medicine |
description |
Abstract Background The neurophysiological examination provides valuable pathophysiological information for the diagnosis, prognosis, and therapy of patients with polyneuropathy (Fuglsang- Fredriksen A., Pugdahl K. Clin Neurophysilogy 122:440–455, 2011). Nerve conduction study (NCS) is the most objective and reliable measure of peripheral nerve function and is considered the gold standard for the diagnosis of most neuropathies . Aim of the study To evaluate the clinical usefulness of nerve conduction study (NCS) in the differentiation between axonal and demyelinating polyneuropathies. Methods In the present study, 125 patients with polyneuropathy were studied ranging age from 9 to 79 years. Thirty-six patients were classified as axonal polyneuropathy, 23 patients as demyelinating, and 9 as mixed, while 57 patients were classified as neuropathic. Nerve conduction study (NCS) and electromyography (EMG) were performed using Nihon Kochden electromyography machine with surface recording and stimulating electrodes . Results There is statistically significant linear correlation between reduction in sensory nerve action potential (SNAP) amplitude and decrease in sensory conduction velocity (SCV) of median and ulnar nerves. Also, there is statistically significant inverse correlation between reduction in compound motor action potential (CMAP) amplitude and increase in distal motor latency (DML). There is statistically significant linear correlation between reduction in compound motor action potential (CMAP) amplitude and decrease in motor conduction velocity (MCV). There is statistically significant linear correlation between reduction in compound motor action potential (CMAP) amplitude and decreased grade of power in both axonal and demyelinating polyneuropathy; statistically significant linear correlation was found between decrease in conduction velocity and decrease in grade of power. Conclusion The present study demonstrates significant correlation between amplitude reduction and conduction slowing in demyelinating as well as axonal polyneuropathy. |
format |
Article in Journal/Newspaper |
author |
Hewedi, Kamel Mahmoud Ali Monzer, Mahmoud Abdelmoety Sobh, Khaled Mohammad Aboelmakarem, Mohammad Abdelhady M. Mohammady, Amir Abdelghaffar Hasan, Mahmoud Mohamad Abdulsalam, Mohammad Fathi Helal, Suzette Ibrahim Ibrahim Ibrahim |
author_facet |
Hewedi, Kamel Mahmoud Ali Monzer, Mahmoud Abdelmoety Sobh, Khaled Mohammad Aboelmakarem, Mohammad Abdelhady M. Mohammady, Amir Abdelghaffar Hasan, Mahmoud Mohamad Abdulsalam, Mohammad Fathi Helal, Suzette Ibrahim Ibrahim Ibrahim |
author_sort |
Hewedi, Kamel Mahmoud Ali |
title |
Clinical and neurophysiological correlation in axonal and demyelinating polyneuropathy |
title_short |
Clinical and neurophysiological correlation in axonal and demyelinating polyneuropathy |
title_full |
Clinical and neurophysiological correlation in axonal and demyelinating polyneuropathy |
title_fullStr |
Clinical and neurophysiological correlation in axonal and demyelinating polyneuropathy |
title_full_unstemmed |
Clinical and neurophysiological correlation in axonal and demyelinating polyneuropathy |
title_sort |
clinical and neurophysiological correlation in axonal and demyelinating polyneuropathy |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1186/s42269-020-00352-6 https://link.springer.com/content/pdf/10.1186/s42269-020-00352-6.pdf https://link.springer.com/article/10.1186/s42269-020-00352-6/fulltext.html |
long_lat |
ENVELOPE(-45.000,-45.000,-60.733,-60.733) |
geographic |
Fredriksen |
geographic_facet |
Fredriksen |
genre |
DML |
genre_facet |
DML |
op_source |
Bulletin of the National Research Centre volume 44, issue 1 ISSN 2522-8307 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s42269-020-00352-6 |
container_title |
Bulletin of the National Research Centre |
container_volume |
44 |
container_issue |
1 |
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1766397717413625856 |