Genetics of canine subvalvular aortic stenosis (SAS)
Abstract Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge...
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crspringernat:10.1186/s40575-021-00103-4 2023-05-15T17:22:06+02:00 Genetics of canine subvalvular aortic stenosis (SAS) Ontiveros, Eric S. Stern, Joshua A. American Kennel Club Canine Health Foundation 2021 http://dx.doi.org/10.1186/s40575-021-00103-4 https://link.springer.com/content/pdf/10.1186/s40575-021-00103-4.pdf https://link.springer.com/article/10.1186/s40575-021-00103-4/fulltext.html en eng Springer Science and Business Media LLC http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ CC-BY Canine Medicine and Genetics volume 8, issue 1 ISSN 2662-9380 General Medicine journal-article 2021 crspringernat https://doi.org/10.1186/s40575-021-00103-4 2022-01-04T12:27:37Z Abstract Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity. This review is focused on the prevalence, inheritance pattern, and current genetic insights of canine SAS. The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital. The mode of inheritance for this disease has also been described in breeds with a high disease prevalence such as the Bullmastiff, Bouvier des Flandres, Dogue de Bordeaux, Golden Retriever, Newfoundland, and Rottweiler. Genetic investigations seeking to identify causative mutations for SAS are lacking with only a single published variant associated with SAS in Newfoundlands. Article in Journal/Newspaper Newfoundland Springer Nature (via Crossref) Bouvier ENVELOPE(-68.133,-68.133,-67.233,-67.233) Flandres ENVELOPE(-63.417,-63.417,-65.033,-65.033) Canine Medicine and Genetics 8 1 |
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Open Polar |
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Springer Nature (via Crossref) |
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crspringernat |
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English |
topic |
General Medicine |
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General Medicine Ontiveros, Eric S. Stern, Joshua A. Genetics of canine subvalvular aortic stenosis (SAS) |
topic_facet |
General Medicine |
description |
Abstract Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity. This review is focused on the prevalence, inheritance pattern, and current genetic insights of canine SAS. The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital. The mode of inheritance for this disease has also been described in breeds with a high disease prevalence such as the Bullmastiff, Bouvier des Flandres, Dogue de Bordeaux, Golden Retriever, Newfoundland, and Rottweiler. Genetic investigations seeking to identify causative mutations for SAS are lacking with only a single published variant associated with SAS in Newfoundlands. |
author2 |
American Kennel Club Canine Health Foundation |
format |
Article in Journal/Newspaper |
author |
Ontiveros, Eric S. Stern, Joshua A. |
author_facet |
Ontiveros, Eric S. Stern, Joshua A. |
author_sort |
Ontiveros, Eric S. |
title |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_short |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_full |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_fullStr |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_full_unstemmed |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_sort |
genetics of canine subvalvular aortic stenosis (sas) |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1186/s40575-021-00103-4 https://link.springer.com/content/pdf/10.1186/s40575-021-00103-4.pdf https://link.springer.com/article/10.1186/s40575-021-00103-4/fulltext.html |
long_lat |
ENVELOPE(-68.133,-68.133,-67.233,-67.233) ENVELOPE(-63.417,-63.417,-65.033,-65.033) |
geographic |
Bouvier Flandres |
geographic_facet |
Bouvier Flandres |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Canine Medicine and Genetics volume 8, issue 1 ISSN 2662-9380 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s40575-021-00103-4 |
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Canine Medicine and Genetics |
container_volume |
8 |
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1 |
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