The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis
Abstract The prevalence of gastroesophageal reflux disease (GERD) is rapidly increasing due to the adoption of a Westernized lifestyle; at the same time, safe and efficient treatment is required due to the side effects and refractoriness of proton pump inhibitors (PPIs). The frequently used multi-co...
Published in: | Applied Biological Chemistry |
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2021
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Online Access: | http://dx.doi.org/10.1186/s13765-021-00617-2 https://link.springer.com/content/pdf/10.1186/s13765-021-00617-2.pdf https://link.springer.com/article/10.1186/s13765-021-00617-2/fulltext.html |
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crspringernat:10.1186/s13765-021-00617-2 2023-05-15T15:59:09+02:00 The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis Park, Junghyun Jang, Dongyeop Phung, Hung Manh Choi, Tae Joon Kim, Chang-Eop Lee, Sanghyun Kang, Ki Sung Choi, Seo-Hyung National Research Foundation of Korea Gachon University 2021 http://dx.doi.org/10.1186/s13765-021-00617-2 https://link.springer.com/content/pdf/10.1186/s13765-021-00617-2.pdf https://link.springer.com/article/10.1186/s13765-021-00617-2/fulltext.html en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Applied Biological Chemistry volume 64, issue 1 ISSN 2468-0834 2468-0842 Organic Chemistry General Biochemistry, Genetics and Molecular Biology journal-article 2021 crspringernat https://doi.org/10.1186/s13765-021-00617-2 2021-11-02T19:50:00Z Abstract The prevalence of gastroesophageal reflux disease (GERD) is rapidly increasing due to the adoption of a Westernized lifestyle; at the same time, safe and efficient treatment is required due to the side effects and refractoriness of proton pump inhibitors (PPIs). The frequently used multi-compound treatment for GERD in the current traditional Korean medicine (TKM) clinical field comprises Crassostrea gigas Thunberg shell (CGTS), Bambusae Caulis in Taeniam (BCT), Ponciri Fructus Immaturus (PFI), Scutellaria baicalensis Georgi (SBG), medicated leaven (ML) and Glycyrrhizae Radix et Rhizoma (GRR). The current review was based on “Kun-Shin-Choa-Sa” theory and network analysis was conducted to explore the potential pharmacological activities, including efficacy and mechanisms of action of multi-compound treatment against GERD. Hypergeometric test results showed that the targets of multi-compound treatment are significantly associated with GERD gene sets, consistent with the literature review findings. In particular, the enrichment analysis indicated that the SBG targets are related to the IL-17 signaling pathway, bile secretion, small-cell lung cancer, and non-small cell lung cancer, corroborating the literature review, particularly concerning anti-inflammatory effect. In the literature review, CGTS and BCT, classified as “Kun,” play a role in anti-acid, anti-inflammatory, and anti-oxidative effects. The complementary “Shin” herbs, PFI and SBG, showed functions related to improving the prolonged gastric emptying rate, peristalsis, and a gastric cytoprotective effect. With the role of “Choa,” ML was suggested to inhibit H. pylori growth and diminish gastric acid secretion, consistent with the gastric acid secretion pathway in the enrichment analysis. However, the enrichment analysis did not show any significantly related pathways for CGTS and PFI, which may reflect the lack of information in the KEGG database in terms of the link between GERD, its mechanisms, and the abundance of minerals in CGTS. Despite the pharmacological potential of multi-compound treatment, this study should be corroborated by well-designed future experimental studies. Article in Journal/Newspaper Crassostrea gigas Springer Nature (via Crossref) Georgi ENVELOPE(-45.133,-45.133,-60.767,-60.767) Gerd ENVELOPE(-45.750,-45.750,-60.666,-60.666) Applied Biological Chemistry 64 1 |
institution |
Open Polar |
collection |
Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Organic Chemistry General Biochemistry, Genetics and Molecular Biology |
spellingShingle |
Organic Chemistry General Biochemistry, Genetics and Molecular Biology Park, Junghyun Jang, Dongyeop Phung, Hung Manh Choi, Tae Joon Kim, Chang-Eop Lee, Sanghyun Kang, Ki Sung Choi, Seo-Hyung The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis |
topic_facet |
Organic Chemistry General Biochemistry, Genetics and Molecular Biology |
description |
Abstract The prevalence of gastroesophageal reflux disease (GERD) is rapidly increasing due to the adoption of a Westernized lifestyle; at the same time, safe and efficient treatment is required due to the side effects and refractoriness of proton pump inhibitors (PPIs). The frequently used multi-compound treatment for GERD in the current traditional Korean medicine (TKM) clinical field comprises Crassostrea gigas Thunberg shell (CGTS), Bambusae Caulis in Taeniam (BCT), Ponciri Fructus Immaturus (PFI), Scutellaria baicalensis Georgi (SBG), medicated leaven (ML) and Glycyrrhizae Radix et Rhizoma (GRR). The current review was based on “Kun-Shin-Choa-Sa” theory and network analysis was conducted to explore the potential pharmacological activities, including efficacy and mechanisms of action of multi-compound treatment against GERD. Hypergeometric test results showed that the targets of multi-compound treatment are significantly associated with GERD gene sets, consistent with the literature review findings. In particular, the enrichment analysis indicated that the SBG targets are related to the IL-17 signaling pathway, bile secretion, small-cell lung cancer, and non-small cell lung cancer, corroborating the literature review, particularly concerning anti-inflammatory effect. In the literature review, CGTS and BCT, classified as “Kun,” play a role in anti-acid, anti-inflammatory, and anti-oxidative effects. The complementary “Shin” herbs, PFI and SBG, showed functions related to improving the prolonged gastric emptying rate, peristalsis, and a gastric cytoprotective effect. With the role of “Choa,” ML was suggested to inhibit H. pylori growth and diminish gastric acid secretion, consistent with the gastric acid secretion pathway in the enrichment analysis. However, the enrichment analysis did not show any significantly related pathways for CGTS and PFI, which may reflect the lack of information in the KEGG database in terms of the link between GERD, its mechanisms, and the abundance of minerals in CGTS. Despite the pharmacological potential of multi-compound treatment, this study should be corroborated by well-designed future experimental studies. |
author2 |
National Research Foundation of Korea Gachon University |
format |
Article in Journal/Newspaper |
author |
Park, Junghyun Jang, Dongyeop Phung, Hung Manh Choi, Tae Joon Kim, Chang-Eop Lee, Sanghyun Kang, Ki Sung Choi, Seo-Hyung |
author_facet |
Park, Junghyun Jang, Dongyeop Phung, Hung Manh Choi, Tae Joon Kim, Chang-Eop Lee, Sanghyun Kang, Ki Sung Choi, Seo-Hyung |
author_sort |
Park, Junghyun |
title |
The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis |
title_short |
The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis |
title_full |
The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis |
title_fullStr |
The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis |
title_full_unstemmed |
The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis |
title_sort |
potential of pharmacological activities of the multi-compound treatment for gerd: literature review and a network pharmacology-based analysis |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1186/s13765-021-00617-2 https://link.springer.com/content/pdf/10.1186/s13765-021-00617-2.pdf https://link.springer.com/article/10.1186/s13765-021-00617-2/fulltext.html |
long_lat |
ENVELOPE(-45.133,-45.133,-60.767,-60.767) ENVELOPE(-45.750,-45.750,-60.666,-60.666) |
geographic |
Georgi Gerd |
geographic_facet |
Georgi Gerd |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Applied Biological Chemistry volume 64, issue 1 ISSN 2468-0834 2468-0842 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s13765-021-00617-2 |
container_title |
Applied Biological Chemistry |
container_volume |
64 |
container_issue |
1 |
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1766394945797619712 |