BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial

• Published in: Trials
• Main Authors: Junqueira-Kipnis, Ana Paula, dos Anjos, Laura Raniere Borges, Barbosa, Lília Cristina de Souza, da Costa, Adeliane Castro, Borges, Kellen Christina Malheiros, Cardoso, Amanda da Rocha Oliveira, Ribeiro, Kaio Mota, Rosa, Sarah Brena Aparecida, Souza, Carine de Castro, das Neves, Rogério Coutinho, Saraiva, Guylherme, da Silva, Sueli Meira, Silveira, Erika Aparecida, Rabahi, Marcelo Fouad, Conte, Marcus Barreto, Kipnis, André
• Other Authors: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
• Format: Article in Journal/Newspaper
• Language: English
• Published: Springer Science and Business Media LLC 2020
• Subjects: Pharmacology (medical); Medicine (miscellaneous); Calmette; SCAR
• Online Access: http://dx.doi.org/10.1186/s13063-020-04822-0; https://link.springer.com/content/pdf/10.1186/s13063-020-04822-0.pdf; https://link.springer.com/article/10.1186/s13063-020-04822-0/fulltext.html

Abstract Objectives The BCG vaccine, widely used in Brazil in new-borns, induces adjuvant protection for several diseases, including childhood virus infections. BCG activates monocytes and innate memory NK cells which are crucial for the antiviral immune response. Therefore, strategies to prevent CO...