Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour
Abstract Background Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many...
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Springer Science and Business Media LLC
2020
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Online Access: | http://dx.doi.org/10.1186/s13023-020-01612-4 http://link.springer.com/content/pdf/10.1186/s13023-020-01612-4.pdf http://link.springer.com/article/10.1186/s13023-020-01612-4/fulltext.html |
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crspringernat:10.1186/s13023-020-01612-4 2023-05-15T15:10:18+02:00 Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour Kuznetsova, Veronika Tyakht, Alexander Akhmadishina, Lyudmila Odintsova, Vera Klimenko, Natalia Kostryukova, Elena Vakhitova, Maria Grigoryeva, Tatyana Malanin, Sergey Vladimirtsev, Vsevolod Nikitina, Raisa Volok, Viktor Osakovskiy, Vladimir Sivtseva, Tatiana Platonov, Fyodor Alexeev, Dmitry Karganova, Galina Russian Science Foundation 2020 http://dx.doi.org/10.1186/s13023-020-01612-4 http://link.springer.com/content/pdf/10.1186/s13023-020-01612-4.pdf http://link.springer.com/article/10.1186/s13023-020-01612-4/fulltext.html en eng Springer Science and Business Media LLC http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ CC-BY Orphanet Journal of Rare Diseases volume 15, issue 1 ISSN 1750-1172 Pharmacology (medical) Genetics(clinical) General Medicine journal-article 2020 crspringernat https://doi.org/10.1186/s13023-020-01612-4 2022-01-04T16:09:36Z Abstract Background Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many hypotheses have been proposed regarding its etiology, including infectious agents, genetics, environmental factors, and immunopathology. Each of these hypotheses has been supported to some extent by epidemiological and experimental data. Nevertheless, none of them has been decisively proven. Gut microbiome is one of the factors that might be involved in VE pathogenesis. Results Here we performed a pilot survey of the stool microbiomes of Yakut subjects with VE (n = 6) and without VE (n = 11). 16S rRNA sequencing showed that in comparison with the control group, the Yakuts with VE had increased proportions of Methanobrevibacter and Christensenella , which are reported to be linked to body mass index, metabolism, dietary habits and potentially to neurodegenerative disorders. The identified associations suggest that the microbiome may be involved in VE. Overall, the Yakut microbiome was quite specific in comparison with other populations, such as metropolitan Russians and native inhabitants of the Canadian Arctic. Conclusions Describing the gut microbiome of indigenous human populations will help to elucidate the impact of dietary and environmental factors on microbial community structure and identify risks linked to the lifestyles of such groups as well as endemic diseases. Article in Journal/Newspaper Arctic Yakut Yakuts Siberia Springer Nature (via Crossref) Arctic Orphanet Journal of Rare Diseases 15 1 |
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Open Polar |
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Springer Nature (via Crossref) |
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crspringernat |
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English |
topic |
Pharmacology (medical) Genetics(clinical) General Medicine |
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Pharmacology (medical) Genetics(clinical) General Medicine Kuznetsova, Veronika Tyakht, Alexander Akhmadishina, Lyudmila Odintsova, Vera Klimenko, Natalia Kostryukova, Elena Vakhitova, Maria Grigoryeva, Tatyana Malanin, Sergey Vladimirtsev, Vsevolod Nikitina, Raisa Volok, Viktor Osakovskiy, Vladimir Sivtseva, Tatiana Platonov, Fyodor Alexeev, Dmitry Karganova, Galina Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
topic_facet |
Pharmacology (medical) Genetics(clinical) General Medicine |
description |
Abstract Background Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many hypotheses have been proposed regarding its etiology, including infectious agents, genetics, environmental factors, and immunopathology. Each of these hypotheses has been supported to some extent by epidemiological and experimental data. Nevertheless, none of them has been decisively proven. Gut microbiome is one of the factors that might be involved in VE pathogenesis. Results Here we performed a pilot survey of the stool microbiomes of Yakut subjects with VE (n = 6) and without VE (n = 11). 16S rRNA sequencing showed that in comparison with the control group, the Yakuts with VE had increased proportions of Methanobrevibacter and Christensenella , which are reported to be linked to body mass index, metabolism, dietary habits and potentially to neurodegenerative disorders. The identified associations suggest that the microbiome may be involved in VE. Overall, the Yakut microbiome was quite specific in comparison with other populations, such as metropolitan Russians and native inhabitants of the Canadian Arctic. Conclusions Describing the gut microbiome of indigenous human populations will help to elucidate the impact of dietary and environmental factors on microbial community structure and identify risks linked to the lifestyles of such groups as well as endemic diseases. |
author2 |
Russian Science Foundation |
format |
Article in Journal/Newspaper |
author |
Kuznetsova, Veronika Tyakht, Alexander Akhmadishina, Lyudmila Odintsova, Vera Klimenko, Natalia Kostryukova, Elena Vakhitova, Maria Grigoryeva, Tatyana Malanin, Sergey Vladimirtsev, Vsevolod Nikitina, Raisa Volok, Viktor Osakovskiy, Vladimir Sivtseva, Tatiana Platonov, Fyodor Alexeev, Dmitry Karganova, Galina |
author_facet |
Kuznetsova, Veronika Tyakht, Alexander Akhmadishina, Lyudmila Odintsova, Vera Klimenko, Natalia Kostryukova, Elena Vakhitova, Maria Grigoryeva, Tatyana Malanin, Sergey Vladimirtsev, Vsevolod Nikitina, Raisa Volok, Viktor Osakovskiy, Vladimir Sivtseva, Tatiana Platonov, Fyodor Alexeev, Dmitry Karganova, Galina |
author_sort |
Kuznetsova, Veronika |
title |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_short |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_full |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_fullStr |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_full_unstemmed |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_sort |
gut microbiome signature of viliuisk encephalomyelitis in yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1186/s13023-020-01612-4 http://link.springer.com/content/pdf/10.1186/s13023-020-01612-4.pdf http://link.springer.com/article/10.1186/s13023-020-01612-4/fulltext.html |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Yakut Yakuts Siberia |
genre_facet |
Arctic Yakut Yakuts Siberia |
op_source |
Orphanet Journal of Rare Diseases volume 15, issue 1 ISSN 1750-1172 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s13023-020-01612-4 |
container_title |
Orphanet Journal of Rare Diseases |
container_volume |
15 |
container_issue |
1 |
_version_ |
1766341339609300992 |