Economic burden of varicella in Europe in the absence of universal varicella vaccination
Abstract Background Though the disease burden of varicella in Europe has been reported previously, the economic burden is still unknown. This study estimated the economic burden of varicella in Europe in the absence of Universal Varicella Vaccination (UVV) in 2018 Euros from both payer (direct costs...
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crspringernat:10.1186/s12889-021-12343-x 2023-05-15T16:52:36+02:00 Economic burden of varicella in Europe in the absence of universal varicella vaccination Pawaskar, Manjiri Méroc, Estelle Samant, Salome Flem, Elmira Bencina, Goran Riera-Montes, Margarita Heininger, Ulrich 2021 http://dx.doi.org/10.1186/s12889-021-12343-x https://link.springer.com/content/pdf/10.1186/s12889-021-12343-x.pdf https://link.springer.com/article/10.1186/s12889-021-12343-x/fulltext.html en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY BMC Public Health volume 21, issue 1 ISSN 1471-2458 Public Health, Environmental and Occupational Health journal-article 2021 crspringernat https://doi.org/10.1186/s12889-021-12343-x 2022-01-04T08:09:07Z Abstract Background Though the disease burden of varicella in Europe has been reported previously, the economic burden is still unknown. This study estimated the economic burden of varicella in Europe in the absence of Universal Varicella Vaccination (UVV) in 2018 Euros from both payer (direct costs) and societal (direct and indirect costs) perspectives. Methods We estimated the country specific and overall annual costs of varicella in absence of UVV in 31 European countries (27 EU countries, plus Iceland, Norway, Switzerland and the United Kingdom). To obtain country specific unit costs and associated healthcare utilization, we conducted a systematic literature review, searching in PubMed, EMBASE, NEED, DARE, REPEC, Open Grey, and public heath websites (1/1/1999–10/15/2019). The number of annual varicella cases, deaths, outpatient visits and hospitalizations were calculated (without UVV) based on age-specific incidence rates (Riera-Montes et al. 2017) and 2018 population data by country. Unit cost per varicella case and disease burden data were combined using stochastic modeling to estimate 2018 costs stratified by country, age and healthcare resource. Results Overall annual total costs associated with varicella were estimated to be €662,592,061 (Range: €309,552,363 to €1,015,631,760) in Europe in absence of UVV. Direct and indirect costs were estimated at €229,076,206 (Range €144,809,557 to €313,342,856) and €433,515,855 (Range €164,742,806 to €702,288,904), respectively. Total cost per case was €121.45 (direct: €41.99; indirect: €79.46). Almost half of the costs were attributed to cases in children under 5 years, owing mainly to caregiver work loss. The distribution of costs by healthcare resource was similar across countries. France and Germany accounted for 49.28% of total annual costs, most likely due to a combination of high numbers of cases and unit costs in these countries. Conclusions The economic burden of varicella across Europe in the absence of UVV is substantial (over 600 M€), primarily driven by caregiver burden including work productivity losses. Article in Journal/Newspaper Iceland Springer Nature (via Crossref) Norway BMC Public Health 21 1 |
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Springer Nature (via Crossref) |
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English |
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Public Health, Environmental and Occupational Health |
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Public Health, Environmental and Occupational Health Pawaskar, Manjiri Méroc, Estelle Samant, Salome Flem, Elmira Bencina, Goran Riera-Montes, Margarita Heininger, Ulrich Economic burden of varicella in Europe in the absence of universal varicella vaccination |
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Public Health, Environmental and Occupational Health |
description |
Abstract Background Though the disease burden of varicella in Europe has been reported previously, the economic burden is still unknown. This study estimated the economic burden of varicella in Europe in the absence of Universal Varicella Vaccination (UVV) in 2018 Euros from both payer (direct costs) and societal (direct and indirect costs) perspectives. Methods We estimated the country specific and overall annual costs of varicella in absence of UVV in 31 European countries (27 EU countries, plus Iceland, Norway, Switzerland and the United Kingdom). To obtain country specific unit costs and associated healthcare utilization, we conducted a systematic literature review, searching in PubMed, EMBASE, NEED, DARE, REPEC, Open Grey, and public heath websites (1/1/1999–10/15/2019). The number of annual varicella cases, deaths, outpatient visits and hospitalizations were calculated (without UVV) based on age-specific incidence rates (Riera-Montes et al. 2017) and 2018 population data by country. Unit cost per varicella case and disease burden data were combined using stochastic modeling to estimate 2018 costs stratified by country, age and healthcare resource. Results Overall annual total costs associated with varicella were estimated to be €662,592,061 (Range: €309,552,363 to €1,015,631,760) in Europe in absence of UVV. Direct and indirect costs were estimated at €229,076,206 (Range €144,809,557 to €313,342,856) and €433,515,855 (Range €164,742,806 to €702,288,904), respectively. Total cost per case was €121.45 (direct: €41.99; indirect: €79.46). Almost half of the costs were attributed to cases in children under 5 years, owing mainly to caregiver work loss. The distribution of costs by healthcare resource was similar across countries. France and Germany accounted for 49.28% of total annual costs, most likely due to a combination of high numbers of cases and unit costs in these countries. Conclusions The economic burden of varicella across Europe in the absence of UVV is substantial (over 600 M€), primarily driven by caregiver burden including work productivity losses. |
format |
Article in Journal/Newspaper |
author |
Pawaskar, Manjiri Méroc, Estelle Samant, Salome Flem, Elmira Bencina, Goran Riera-Montes, Margarita Heininger, Ulrich |
author_facet |
Pawaskar, Manjiri Méroc, Estelle Samant, Salome Flem, Elmira Bencina, Goran Riera-Montes, Margarita Heininger, Ulrich |
author_sort |
Pawaskar, Manjiri |
title |
Economic burden of varicella in Europe in the absence of universal varicella vaccination |
title_short |
Economic burden of varicella in Europe in the absence of universal varicella vaccination |
title_full |
Economic burden of varicella in Europe in the absence of universal varicella vaccination |
title_fullStr |
Economic burden of varicella in Europe in the absence of universal varicella vaccination |
title_full_unstemmed |
Economic burden of varicella in Europe in the absence of universal varicella vaccination |
title_sort |
economic burden of varicella in europe in the absence of universal varicella vaccination |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1186/s12889-021-12343-x https://link.springer.com/content/pdf/10.1186/s12889-021-12343-x.pdf https://link.springer.com/article/10.1186/s12889-021-12343-x/fulltext.html |
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Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
BMC Public Health volume 21, issue 1 ISSN 1471-2458 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s12889-021-12343-x |
container_title |
BMC Public Health |
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21 |
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1 |
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1766042969529384960 |