Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study
Abstract Background High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and ag...
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2021
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Online Access: | http://dx.doi.org/10.1186/s12872-020-01826-1 http://link.springer.com/content/pdf/10.1186/s12872-020-01826-1.pdf http://link.springer.com/article/10.1186/s12872-020-01826-1/fulltext.html |
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crspringernat:10.1186/s12872-020-01826-1 2023-05-15T18:34:27+02:00 Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study Bekkelund, Svein Ivar 2021 http://dx.doi.org/10.1186/s12872-020-01826-1 http://link.springer.com/content/pdf/10.1186/s12872-020-01826-1.pdf http://link.springer.com/article/10.1186/s12872-020-01826-1/fulltext.html en eng Springer Science and Business Media LLC http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ CC-BY BMC Cardiovascular Disorders volume 21, issue 1 ISSN 1471-2261 Cardiology and Cardiovascular Medicine journal-article 2021 crspringernat https://doi.org/10.1186/s12872-020-01826-1 2022-01-04T11:26:01Z Abstract Background High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population. Methods Cross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromsø 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP). Results Abnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88–1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86–0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found. Conclusion This study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies. Article in Journal/Newspaper Tromsø Springer Nature (via Crossref) Tromsø BMC Cardiovascular Disorders 21 1 |
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Springer Nature (via Crossref) |
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English |
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Cardiology and Cardiovascular Medicine |
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Cardiology and Cardiovascular Medicine Bekkelund, Svein Ivar Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
topic_facet |
Cardiology and Cardiovascular Medicine |
description |
Abstract Background High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population. Methods Cross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromsø 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP). Results Abnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88–1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86–0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found. Conclusion This study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies. |
format |
Article in Journal/Newspaper |
author |
Bekkelund, Svein Ivar |
author_facet |
Bekkelund, Svein Ivar |
author_sort |
Bekkelund, Svein Ivar |
title |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_short |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_full |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_fullStr |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_full_unstemmed |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_sort |
serum alanine aminotransferase activity and risk factors for cardiovascular disease in a caucasian population: the tromsø study |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
http://dx.doi.org/10.1186/s12872-020-01826-1 http://link.springer.com/content/pdf/10.1186/s12872-020-01826-1.pdf http://link.springer.com/article/10.1186/s12872-020-01826-1/fulltext.html |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
BMC Cardiovascular Disorders volume 21, issue 1 ISSN 1471-2261 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s12872-020-01826-1 |
container_title |
BMC Cardiovascular Disorders |
container_volume |
21 |
container_issue |
1 |
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1766219200111575040 |