Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway
Abstract Background Cardiovascular disease (CVD) mortality is substantially higher in Russia than in neighbouring Norway. We aimed to compare blood pressure- and lipid-lowering medication use and proportion meeting treatment targets between general population samples in the two countries in those wi...
Published in: | BMC Cardiovascular Disorders |
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Language: | English |
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Springer Science and Business Media LLC
2020
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Online Access: | http://dx.doi.org/10.1186/s12872-020-01513-1 https://link.springer.com/content/pdf/10.1186/s12872-020-01513-1.pdf https://link.springer.com/article/10.1186/s12872-020-01513-1/fulltext.html |
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crspringernat:10.1186/s12872-020-01513-1 2023-05-15T18:34:18+02:00 Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway Cook, Sarah Hopstock, Laila A. Eggen, Anne Elise Bates, Katie Iakunchykova, Olena Kontsevaya, Anna McKee, Martin Schirmer, Henrik Voevoda, Michael Kudryavtsev, Alexander V. Malyutina, Sofia Leon, David A. Wellcome Trust UiT, The Arctic University of Norway Norwegian Institute of Public Health Norwegian Ministry of Health and Social Affairs Northern Norway Regional Health Authority Tromsø County 2020 http://dx.doi.org/10.1186/s12872-020-01513-1 https://link.springer.com/content/pdf/10.1186/s12872-020-01513-1.pdf https://link.springer.com/article/10.1186/s12872-020-01513-1/fulltext.html en eng Springer Science and Business Media LLC https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 CC-BY BMC Cardiovascular Disorders volume 20, issue 1 ISSN 1471-2261 Cardiology and Cardiovascular Medicine journal-article 2020 crspringernat https://doi.org/10.1186/s12872-020-01513-1 2022-01-04T16:30:46Z Abstract Background Cardiovascular disease (CVD) mortality is substantially higher in Russia than in neighbouring Norway. We aimed to compare blood pressure- and lipid-lowering medication use and proportion meeting treatment targets between general population samples in the two countries in those with CVD and diabetes. Methods The study population was adults aged 40–69 years reporting a diagnosis of myocardial infarction (MI), stroke and/or diabetes participating in cross-sectional population-based studies in Russia (Know Your Heart (KYH) 2015–18 N = 626) and Norway (The Tromsø Study 2015–16 (Tromsø 7) N = 1353). Reported medications were coded according to the 2016 WHO Anatomical Therapeutic Chemical Classification system. Treatment targets were defined using the Joint European Societies guidelines for CVD prevention in clinical practice (2016). Results Age- and sex-standardized prevalence of use of lipid-lowering medications was higher in Tromsø 7 for all three conditions with a disproportionately large difference in those reporting MI (+ 48% (95% CI 39, 57%)). Proportion meeting treatment targets for LDL cholesterol was poor in both studies (age- and sex-standardized prevalence of control KYH vs Tromsø 7: MI 5.1% vs 10.1%; stroke 11.6% vs 5.8%; diabetes 24.9% vs 23.3%). Use of antihypertensive medication was higher in KYH for stroke (+ 40% (95% CI 30, 50%)) and diabetes (+ 27% (95% CI 19, 34%)) groups but approximately equal for the MI group (− 1% (95% CI -1, 1%)). Proportion meeting blood pressure targets was lower in KYH vs Tromsø 7 (MI 51.8% vs 76.3%; stroke 49.5% vs 69.6%; diabetes 51.9% vs 63.9%). Conclusions We identified different patterns of medication use in people with CVD and diabetes. However despite higher use of lipid-lowering medication in the Norwegian study treatment to target for total cholesterol was poor in both Russian and Norwegian studies. In contrast we found higher levels of use of antihypertensive medications in the Russian study but also that less participants met treatment targets for blood pressure. Further work should investigate what factors are responsible for this seeming paradox and how management of modifiable risk factors for secondary prevention could be improved. Article in Journal/Newspaper Tromsø Springer Nature (via Crossref) Norway Tromsø BMC Cardiovascular Disorders 20 1 |
institution |
Open Polar |
collection |
Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Cardiology and Cardiovascular Medicine |
spellingShingle |
Cardiology and Cardiovascular Medicine Cook, Sarah Hopstock, Laila A. Eggen, Anne Elise Bates, Katie Iakunchykova, Olena Kontsevaya, Anna McKee, Martin Schirmer, Henrik Voevoda, Michael Kudryavtsev, Alexander V. Malyutina, Sofia Leon, David A. Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
topic_facet |
Cardiology and Cardiovascular Medicine |
description |
Abstract Background Cardiovascular disease (CVD) mortality is substantially higher in Russia than in neighbouring Norway. We aimed to compare blood pressure- and lipid-lowering medication use and proportion meeting treatment targets between general population samples in the two countries in those with CVD and diabetes. Methods The study population was adults aged 40–69 years reporting a diagnosis of myocardial infarction (MI), stroke and/or diabetes participating in cross-sectional population-based studies in Russia (Know Your Heart (KYH) 2015–18 N = 626) and Norway (The Tromsø Study 2015–16 (Tromsø 7) N = 1353). Reported medications were coded according to the 2016 WHO Anatomical Therapeutic Chemical Classification system. Treatment targets were defined using the Joint European Societies guidelines for CVD prevention in clinical practice (2016). Results Age- and sex-standardized prevalence of use of lipid-lowering medications was higher in Tromsø 7 for all three conditions with a disproportionately large difference in those reporting MI (+ 48% (95% CI 39, 57%)). Proportion meeting treatment targets for LDL cholesterol was poor in both studies (age- and sex-standardized prevalence of control KYH vs Tromsø 7: MI 5.1% vs 10.1%; stroke 11.6% vs 5.8%; diabetes 24.9% vs 23.3%). Use of antihypertensive medication was higher in KYH for stroke (+ 40% (95% CI 30, 50%)) and diabetes (+ 27% (95% CI 19, 34%)) groups but approximately equal for the MI group (− 1% (95% CI -1, 1%)). Proportion meeting blood pressure targets was lower in KYH vs Tromsø 7 (MI 51.8% vs 76.3%; stroke 49.5% vs 69.6%; diabetes 51.9% vs 63.9%). Conclusions We identified different patterns of medication use in people with CVD and diabetes. However despite higher use of lipid-lowering medication in the Norwegian study treatment to target for total cholesterol was poor in both Russian and Norwegian studies. In contrast we found higher levels of use of antihypertensive medications in the Russian study but also that less participants met treatment targets for blood pressure. Further work should investigate what factors are responsible for this seeming paradox and how management of modifiable risk factors for secondary prevention could be improved. |
author2 |
Wellcome Trust UiT, The Arctic University of Norway Norwegian Institute of Public Health Norwegian Ministry of Health and Social Affairs Northern Norway Regional Health Authority Tromsø County |
format |
Article in Journal/Newspaper |
author |
Cook, Sarah Hopstock, Laila A. Eggen, Anne Elise Bates, Katie Iakunchykova, Olena Kontsevaya, Anna McKee, Martin Schirmer, Henrik Voevoda, Michael Kudryavtsev, Alexander V. Malyutina, Sofia Leon, David A. |
author_facet |
Cook, Sarah Hopstock, Laila A. Eggen, Anne Elise Bates, Katie Iakunchykova, Olena Kontsevaya, Anna McKee, Martin Schirmer, Henrik Voevoda, Michael Kudryavtsev, Alexander V. Malyutina, Sofia Leon, David A. |
author_sort |
Cook, Sarah |
title |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_short |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_full |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_fullStr |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_full_unstemmed |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_sort |
pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in russia and norway |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1186/s12872-020-01513-1 https://link.springer.com/content/pdf/10.1186/s12872-020-01513-1.pdf https://link.springer.com/article/10.1186/s12872-020-01513-1/fulltext.html |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
BMC Cardiovascular Disorders volume 20, issue 1 ISSN 1471-2261 |
op_rights |
https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s12872-020-01513-1 |
container_title |
BMC Cardiovascular Disorders |
container_volume |
20 |
container_issue |
1 |
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1766218985214312448 |