Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface
Abstract Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of g...
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Online Access: | http://dx.doi.org/10.1186/s12863-020-0816-y http://link.springer.com/content/pdf/10.1186/s12863-020-0816-y.pdf http://link.springer.com/article/10.1186/s12863-020-0816-y/fulltext.html |
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crspringernat:10.1186/s12863-020-0816-y 2023-05-15T15:30:57+02:00 Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. Research Council of Norway via the projects INTERACT Research Council of Norway via the projects QUANTESCAPE 2020 http://dx.doi.org/10.1186/s12863-020-0816-y http://link.springer.com/content/pdf/10.1186/s12863-020-0816-y.pdf http://link.springer.com/article/10.1186/s12863-020-0816-y/fulltext.html en eng Springer Science and Business Media LLC http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ CC-BY BMC Genetics volume 21, issue 1 ISSN 1471-2156 Genetics(clinical) Genetics journal-article 2020 crspringernat https://doi.org/10.1186/s12863-020-0816-y 2022-01-04T16:16:51Z Abstract Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations. Results After rearing fish in common-garden experiments under aquaculture conditions, we performed a variance component analysis in four mapping populations totaling ~ 7000 individuals from six wild, two domesticated and three F1 wild/domesticated hybrid strains. Across the four independent datasets, genome-wide significant quantitative trait loci (QTLs) associated with weight and length were detected on a total of 18 chromosomes, reflecting the polygenic nature of growth. Significant QTLs correlated with both length and weight were detected on chromosomes 2, 6 and 9 in multiple datasets. Significantly, epistatic QTLs were detected in all datasets. Discussion The observed interactions demonstrated that the phenotypic effect of inheriting an allele deviated between half-sib families. Gene-by-gene interactions were also suggested, where the combined effect of two loci resulted in a genetic effect upon phenotypic variance, while no genetic effect was detected when the two loci were considered separately. To our knowledge, this is the first documentation of epistasis in a quantitative trait in Atlantic salmon. These novel results are of relevance for breeding programs, and for predicting the evolutionary consequences of domestication-introgression in wild populations. Article in Journal/Newspaper Atlantic salmon Springer Nature (via Crossref) BMC Genetics 21 1 |
institution |
Open Polar |
collection |
Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Genetics(clinical) Genetics |
spellingShingle |
Genetics(clinical) Genetics Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
topic_facet |
Genetics(clinical) Genetics |
description |
Abstract Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations. Results After rearing fish in common-garden experiments under aquaculture conditions, we performed a variance component analysis in four mapping populations totaling ~ 7000 individuals from six wild, two domesticated and three F1 wild/domesticated hybrid strains. Across the four independent datasets, genome-wide significant quantitative trait loci (QTLs) associated with weight and length were detected on a total of 18 chromosomes, reflecting the polygenic nature of growth. Significant QTLs correlated with both length and weight were detected on chromosomes 2, 6 and 9 in multiple datasets. Significantly, epistatic QTLs were detected in all datasets. Discussion The observed interactions demonstrated that the phenotypic effect of inheriting an allele deviated between half-sib families. Gene-by-gene interactions were also suggested, where the combined effect of two loci resulted in a genetic effect upon phenotypic variance, while no genetic effect was detected when the two loci were considered separately. To our knowledge, this is the first documentation of epistasis in a quantitative trait in Atlantic salmon. These novel results are of relevance for breeding programs, and for predicting the evolutionary consequences of domestication-introgression in wild populations. |
author2 |
Research Council of Norway via the projects INTERACT Research Council of Norway via the projects QUANTESCAPE |
format |
Article in Journal/Newspaper |
author |
Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. |
author_facet |
Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. |
author_sort |
Besnier, Francois |
title |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_short |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_full |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_fullStr |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_full_unstemmed |
Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface |
title_sort |
epistatic regulation of growth in atlantic salmon revealed: a qtl study performed on the domesticated-wild interface |
publisher |
Springer Science and Business Media LLC |
publishDate |
2020 |
url |
http://dx.doi.org/10.1186/s12863-020-0816-y http://link.springer.com/content/pdf/10.1186/s12863-020-0816-y.pdf http://link.springer.com/article/10.1186/s12863-020-0816-y/fulltext.html |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
BMC Genetics volume 21, issue 1 ISSN 1471-2156 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s12863-020-0816-y |
container_title |
BMC Genetics |
container_volume |
21 |
container_issue |
1 |
_version_ |
1766361439046467584 |