The prevalence of human papillomavirus and its impact on cervical dysplasia in Northern Canada
Abstract Introduction Certain types of the Human Papillomavirus (HPV) are sexually transmitted and highly associated with development of cervical dysplasia and cervical cancer but the distribution of HPV infection in the North, particularly amongst First Nations, Metis, and Inuit peoples, is little...
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Online Access: | http://dx.doi.org/10.1186/1750-9378-8-25 https://link.springer.com/content/pdf/10.1186/1750-9378-8-25.pdf |
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crspringernat:10.1186/1750-9378-8-25 2023-05-15T16:17:00+02:00 The prevalence of human papillomavirus and its impact on cervical dysplasia in Northern Canada Jiang, Ying Brassard, Paul Severini, Alberto Mao, Yang Li, Y Anita Laroche, Julie Chatwood, Susan Corriveau, Andre Kandola, Kami Hanley, Brendan Sobol, Isaac Ar-Rushdi, Muna Johnson, Gordon Lo, Jane Ratnam, Sam Wong, Tom Demers, Alain Jayaraman, Gayatri Totten, Stephanie Morrison, Howard 2013 http://dx.doi.org/10.1186/1750-9378-8-25 https://link.springer.com/content/pdf/10.1186/1750-9378-8-25.pdf en eng Springer Science and Business Media LLC Infectious Agents and Cancer volume 8, issue 1 ISSN 1750-9378 Cancer Research Infectious Diseases Oncology Epidemiology journal-article 2013 crspringernat https://doi.org/10.1186/1750-9378-8-25 2022-01-04T13:37:52Z Abstract Introduction Certain types of the Human Papillomavirus (HPV) are sexually transmitted and highly associated with development of cervical dysplasia and cervical cancer but the distribution of HPV infection in the North, particularly amongst First Nations, Metis, and Inuit peoples, is little known. The purposes of the study are to identify the prevalence of type-specific HPV infections and the association of different HPV types with cervical dysplasia among women in Northern Canada. Methods This was a cross-sectional study with attendants of the routine or scheduled Pap testing program in the Northwest Territories (NWT), Nunavut, Labrador and Yukon, Canada. Approximately half of each sample was used for Pap test and the remaining was used for HPV genotyping using a Luminex-based method. Pap test results, HPV types, and demographic information were linked for analyses. Results Results from 14,598 specimens showed that HPV infection was approximately 50% higher among the Aboriginal than the non-Aboriginal population (27.6% vs. 18.5%). Although the most common HPV type detected was HPV 16 across region, the prevalence of other high risk HPV types was different. The age-specific HPV prevalence among Aboriginal showed a āUā shape which contrasted to non-Aboriginal. The association of HPV infection with cervical dysplasia was similar in both Aboriginal and non-Aboriginal populations. Conclusions The HPV prevalence was higher in Northern Canada than in other Areas in Canada. The prevalence showed a higher rate of other high risk HPV infections but no difference of HPV 16/18 infections among Aboriginal in comparison with non-Aboriginal women. This study provides baseline information on HPV prevalence that may assist in surveillance and evaluation systems to track and assess HPV vaccine programs. Article in Journal/Newspaper First Nations inuit Metis Northwest Territories Nunavut Yukon Springer Nature (via Crossref) Canada Northwest Territories Nunavut Yukon Infectious Agents and Cancer 8 1 |
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Springer Nature (via Crossref) |
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English |
topic |
Cancer Research Infectious Diseases Oncology Epidemiology |
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Cancer Research Infectious Diseases Oncology Epidemiology Jiang, Ying Brassard, Paul Severini, Alberto Mao, Yang Li, Y Anita Laroche, Julie Chatwood, Susan Corriveau, Andre Kandola, Kami Hanley, Brendan Sobol, Isaac Ar-Rushdi, Muna Johnson, Gordon Lo, Jane Ratnam, Sam Wong, Tom Demers, Alain Jayaraman, Gayatri Totten, Stephanie Morrison, Howard The prevalence of human papillomavirus and its impact on cervical dysplasia in Northern Canada |
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Cancer Research Infectious Diseases Oncology Epidemiology |
description |
Abstract Introduction Certain types of the Human Papillomavirus (HPV) are sexually transmitted and highly associated with development of cervical dysplasia and cervical cancer but the distribution of HPV infection in the North, particularly amongst First Nations, Metis, and Inuit peoples, is little known. The purposes of the study are to identify the prevalence of type-specific HPV infections and the association of different HPV types with cervical dysplasia among women in Northern Canada. Methods This was a cross-sectional study with attendants of the routine or scheduled Pap testing program in the Northwest Territories (NWT), Nunavut, Labrador and Yukon, Canada. Approximately half of each sample was used for Pap test and the remaining was used for HPV genotyping using a Luminex-based method. Pap test results, HPV types, and demographic information were linked for analyses. Results Results from 14,598 specimens showed that HPV infection was approximately 50% higher among the Aboriginal than the non-Aboriginal population (27.6% vs. 18.5%). Although the most common HPV type detected was HPV 16 across region, the prevalence of other high risk HPV types was different. The age-specific HPV prevalence among Aboriginal showed a āUā shape which contrasted to non-Aboriginal. The association of HPV infection with cervical dysplasia was similar in both Aboriginal and non-Aboriginal populations. Conclusions The HPV prevalence was higher in Northern Canada than in other Areas in Canada. The prevalence showed a higher rate of other high risk HPV infections but no difference of HPV 16/18 infections among Aboriginal in comparison with non-Aboriginal women. This study provides baseline information on HPV prevalence that may assist in surveillance and evaluation systems to track and assess HPV vaccine programs. |
format |
Article in Journal/Newspaper |
author |
Jiang, Ying Brassard, Paul Severini, Alberto Mao, Yang Li, Y Anita Laroche, Julie Chatwood, Susan Corriveau, Andre Kandola, Kami Hanley, Brendan Sobol, Isaac Ar-Rushdi, Muna Johnson, Gordon Lo, Jane Ratnam, Sam Wong, Tom Demers, Alain Jayaraman, Gayatri Totten, Stephanie Morrison, Howard |
author_facet |
Jiang, Ying Brassard, Paul Severini, Alberto Mao, Yang Li, Y Anita Laroche, Julie Chatwood, Susan Corriveau, Andre Kandola, Kami Hanley, Brendan Sobol, Isaac Ar-Rushdi, Muna Johnson, Gordon Lo, Jane Ratnam, Sam Wong, Tom Demers, Alain Jayaraman, Gayatri Totten, Stephanie Morrison, Howard |
author_sort |
Jiang, Ying |
title |
The prevalence of human papillomavirus and its impact on cervical dysplasia in Northern Canada |
title_short |
The prevalence of human papillomavirus and its impact on cervical dysplasia in Northern Canada |
title_full |
The prevalence of human papillomavirus and its impact on cervical dysplasia in Northern Canada |
title_fullStr |
The prevalence of human papillomavirus and its impact on cervical dysplasia in Northern Canada |
title_full_unstemmed |
The prevalence of human papillomavirus and its impact on cervical dysplasia in Northern Canada |
title_sort |
prevalence of human papillomavirus and its impact on cervical dysplasia in northern canada |
publisher |
Springer Science and Business Media LLC |
publishDate |
2013 |
url |
http://dx.doi.org/10.1186/1750-9378-8-25 https://link.springer.com/content/pdf/10.1186/1750-9378-8-25.pdf |
geographic |
Canada Northwest Territories Nunavut Yukon |
geographic_facet |
Canada Northwest Territories Nunavut Yukon |
genre |
First Nations inuit Metis Northwest Territories Nunavut Yukon |
genre_facet |
First Nations inuit Metis Northwest Territories Nunavut Yukon |
op_source |
Infectious Agents and Cancer volume 8, issue 1 ISSN 1750-9378 |
op_doi |
https://doi.org/10.1186/1750-9378-8-25 |
container_title |
Infectious Agents and Cancer |
container_volume |
8 |
container_issue |
1 |
_version_ |
1766002850284961792 |