Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population
Abstract Background Tissue concentrations of fatty acids (FAs) and genetic variations are well-known factors which affect the cardiovascular disease (CVD) risk. The objective was to examine whether the genetic variability of 20 candidate genes and red blood cells (RBCs) percentage of total n -3 poly...
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Online Access: | http://dx.doi.org/10.1186/1743-7075-10-26 https://link.springer.com/content/pdf/10.1186/1743-7075-10-26.pdf |
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crspringernat:10.1186/1743-7075-10-26 2023-05-15T16:55:00+02:00 Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population Rudkowska, Iwona Ouellette, Catherine Dewailly, Eric Hegele, Robert A Boiteau, Véronique Dubé-Linteau, Ariane Abdous, Belkacem Proust, Françoise Giguère, Yves Julien, Pierre Château-Degat, Marie-Ludivine Vohl, Marie-Claude 2013 http://dx.doi.org/10.1186/1743-7075-10-26 https://link.springer.com/content/pdf/10.1186/1743-7075-10-26.pdf en eng Springer Science and Business Media LLC Nutrition & Metabolism volume 10, issue 1 ISSN 1743-7075 Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Medicine (miscellaneous) journal-article 2013 crspringernat https://doi.org/10.1186/1743-7075-10-26 2022-01-04T16:10:26Z Abstract Background Tissue concentrations of fatty acids (FAs) and genetic variations are well-known factors which affect the cardiovascular disease (CVD) risk. The objective was to examine whether the genetic variability of 20 candidate genes and red blood cells (RBCs) percentage of total n -3 polyunsaturated fatty acids (PUFA), a biomarker of dietary n -3 PUFA intake, modulate lipid related CVD risk factors in the Inuit population. Methods Data from the Qanuippitaa Nunavik Health Survey (n = 553) were analysed via multivariate regression models with 40 known polymorphisms, RBCs percentage of n -3 PUFA, and the interaction term to take into account the effect on plasma lipid and apolipoporotein levels. Results Individuals being heterozygotes for CETP C-4502T (rs183130) or G-971A (rs4783961) together with higher n -3 PUFA had lower triacylglycerol (TG) concentrations compared to homozygotes for the minor allele. Further, effects of a stronger beneficial association between n -3 PUFA in RBCs and plasma lipid parameters- including lower total cholesterol (TC), lower low-density lipoprotein cholesterol (LDL-C) or higher high-density lipoprotein cholesterol (HDL-C) concentrations- were associated with AGT M235T (rs699) TT genotype, CETP G-971A (rs4783961) AG genotype, T allele carriers of CETP C-4502T (rs183130), and T allele carriers of CETP Ile405Val (rs5882). In contrast, higher n -3 PUFA in RBCs were associated with adverse lipid profiles- including increased LDL-C, increased apolipoprotein B100 or decreased HDL-C concentrations- in G allele carriers of the APOA5 -3 A/G (rs651821), C allele carriers of APOA5 T-1131C (rs662799), G carriers of APOC3 SstI (rs5128) and G carriers of APOA4 Asn147Ser (rs5104). Conclusion Overall, these results suggest that percentage of total n -3 PUFA of RBCs are associated with lipids related CVD risk factors conferred by genetic variations in the Inuit population. Article in Journal/Newspaper inuit Nunavik Springer Nature (via Crossref) Nunavik Nutrition & Metabolism 10 1 26 |
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Open Polar |
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Springer Nature (via Crossref) |
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crspringernat |
language |
English |
topic |
Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Medicine (miscellaneous) |
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Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Medicine (miscellaneous) Rudkowska, Iwona Ouellette, Catherine Dewailly, Eric Hegele, Robert A Boiteau, Véronique Dubé-Linteau, Ariane Abdous, Belkacem Proust, Françoise Giguère, Yves Julien, Pierre Château-Degat, Marie-Ludivine Vohl, Marie-Claude Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
topic_facet |
Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Medicine (miscellaneous) |
description |
Abstract Background Tissue concentrations of fatty acids (FAs) and genetic variations are well-known factors which affect the cardiovascular disease (CVD) risk. The objective was to examine whether the genetic variability of 20 candidate genes and red blood cells (RBCs) percentage of total n -3 polyunsaturated fatty acids (PUFA), a biomarker of dietary n -3 PUFA intake, modulate lipid related CVD risk factors in the Inuit population. Methods Data from the Qanuippitaa Nunavik Health Survey (n = 553) were analysed via multivariate regression models with 40 known polymorphisms, RBCs percentage of n -3 PUFA, and the interaction term to take into account the effect on plasma lipid and apolipoporotein levels. Results Individuals being heterozygotes for CETP C-4502T (rs183130) or G-971A (rs4783961) together with higher n -3 PUFA had lower triacylglycerol (TG) concentrations compared to homozygotes for the minor allele. Further, effects of a stronger beneficial association between n -3 PUFA in RBCs and plasma lipid parameters- including lower total cholesterol (TC), lower low-density lipoprotein cholesterol (LDL-C) or higher high-density lipoprotein cholesterol (HDL-C) concentrations- were associated with AGT M235T (rs699) TT genotype, CETP G-971A (rs4783961) AG genotype, T allele carriers of CETP C-4502T (rs183130), and T allele carriers of CETP Ile405Val (rs5882). In contrast, higher n -3 PUFA in RBCs were associated with adverse lipid profiles- including increased LDL-C, increased apolipoprotein B100 or decreased HDL-C concentrations- in G allele carriers of the APOA5 -3 A/G (rs651821), C allele carriers of APOA5 T-1131C (rs662799), G carriers of APOC3 SstI (rs5128) and G carriers of APOA4 Asn147Ser (rs5104). Conclusion Overall, these results suggest that percentage of total n -3 PUFA of RBCs are associated with lipids related CVD risk factors conferred by genetic variations in the Inuit population. |
format |
Article in Journal/Newspaper |
author |
Rudkowska, Iwona Ouellette, Catherine Dewailly, Eric Hegele, Robert A Boiteau, Véronique Dubé-Linteau, Ariane Abdous, Belkacem Proust, Françoise Giguère, Yves Julien, Pierre Château-Degat, Marie-Ludivine Vohl, Marie-Claude |
author_facet |
Rudkowska, Iwona Ouellette, Catherine Dewailly, Eric Hegele, Robert A Boiteau, Véronique Dubé-Linteau, Ariane Abdous, Belkacem Proust, Françoise Giguère, Yves Julien, Pierre Château-Degat, Marie-Ludivine Vohl, Marie-Claude |
author_sort |
Rudkowska, Iwona |
title |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_short |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_full |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_fullStr |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_full_unstemmed |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_sort |
omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the inuit population |
publisher |
Springer Science and Business Media LLC |
publishDate |
2013 |
url |
http://dx.doi.org/10.1186/1743-7075-10-26 https://link.springer.com/content/pdf/10.1186/1743-7075-10-26.pdf |
geographic |
Nunavik |
geographic_facet |
Nunavik |
genre |
inuit Nunavik |
genre_facet |
inuit Nunavik |
op_source |
Nutrition & Metabolism volume 10, issue 1 ISSN 1743-7075 |
op_doi |
https://doi.org/10.1186/1743-7075-10-26 |
container_title |
Nutrition & Metabolism |
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10 |
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1 |
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26 |
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1766045968212426752 |