Xenoestrogenic activity in blood of European and Inuit populations
Abstract Background Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups...
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Springer Science and Business Media LLC
2006
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Online Access: | http://dx.doi.org/10.1186/1476-069x-5-12 http://link.springer.com/content/pdf/10.1186/1476-069X-5-12.pdf http://link.springer.com/article/10.1186/1476-069X-5-12/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-5-12 https://link.springer.com/content/pdf/10.1186/1476-069X-5-12.pdf |
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crspringernat:10.1186/1476-069x-5-12 2023-05-15T16:31:12+02:00 Xenoestrogenic activity in blood of European and Inuit populations Bonefeld-Jorgensen, Eva C Hjelmborg, Philip S Reinert, Thayaline S Andersen, Birgitte S Lesovoy, Vladimir Lindh, Christian H Hagmar, Lars Giwercman, Aleksander Erlandsen, Mogens Manicardi, Gian-Carlo Spanò, Marcello Toft, Gunnar Bonde, Jens Peter 2006 http://dx.doi.org/10.1186/1476-069x-5-12 http://link.springer.com/content/pdf/10.1186/1476-069X-5-12.pdf http://link.springer.com/article/10.1186/1476-069X-5-12/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-5-12 https://link.springer.com/content/pdf/10.1186/1476-069X-5-12.pdf en eng Springer Science and Business Media LLC http://www.springer.com/tdm Environmental Health volume 5, issue 1 ISSN 1476-069X Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health journal-article 2006 crspringernat https://doi.org/10.1186/1476-069x-5-12 2022-01-04T09:03:32Z Abstract Background Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups with varying POP exposure, and to evaluate correlations to the POP biomarkers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis ( p -chlorophenyl)-ethylene ( p,p' -DDE). Methods The study included 358 men: Greenlandic Inuit's, Swedish fishermen, and Warsaw (Poland) and Kharkiv (Ukraine) inhabitants. Xenoestrogenicity of serum extracts alone (XER) and XER competitive (XERcomp) effect on 17β-estradiol induced estrogen receptor (ER) transactivity were assessed in the hormone free, lipophilic serum fraction containing the POPs using the MVLN human breast cancer cell line. Results No agonistic XER activity was exhibited for Inuit serum samples, while 12 – 24% of the European samples had detectable agonistic XER activity. On the contrary, 71% of Inuit serum samples antagonized XERcomp compared to 7 – 30 % in the other regions. XER and XERcomp were not or weakly correlated to the two POP markers. XER activity of Inuit samples was negatively associated to levels of CB-153 and p,p '-DDE. For the Warsaw group a positive and negative correlation between XER and p,p' -DDE and estradiol equivalence level and CB-153 levels was found. Conclusion No strong consistent association between xenoestrogenic net activity and the two POP markers was found. The results showed that the selected POP markers alone can not predict the integrated xenoestrogenic serum activity. Correlations to the POP markers were found at the extreme edge; the Inuit's and Warsaw study groups eliciting high frequency of samples with ER antagonistic and agonistic activity, respectively. We suggest that the variation in xenoestrogenic serum activity reflects differences in POP exposure mixture, genetic factors and/or life style factors. Article in Journal/Newspaper greenlandic inuit Springer Nature (via Crossref) Environmental Health 5 1 |
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Open Polar |
collection |
Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
spellingShingle |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Bonefeld-Jorgensen, Eva C Hjelmborg, Philip S Reinert, Thayaline S Andersen, Birgitte S Lesovoy, Vladimir Lindh, Christian H Hagmar, Lars Giwercman, Aleksander Erlandsen, Mogens Manicardi, Gian-Carlo Spanò, Marcello Toft, Gunnar Bonde, Jens Peter Xenoestrogenic activity in blood of European and Inuit populations |
topic_facet |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
description |
Abstract Background Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups with varying POP exposure, and to evaluate correlations to the POP biomarkers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis ( p -chlorophenyl)-ethylene ( p,p' -DDE). Methods The study included 358 men: Greenlandic Inuit's, Swedish fishermen, and Warsaw (Poland) and Kharkiv (Ukraine) inhabitants. Xenoestrogenicity of serum extracts alone (XER) and XER competitive (XERcomp) effect on 17β-estradiol induced estrogen receptor (ER) transactivity were assessed in the hormone free, lipophilic serum fraction containing the POPs using the MVLN human breast cancer cell line. Results No agonistic XER activity was exhibited for Inuit serum samples, while 12 – 24% of the European samples had detectable agonistic XER activity. On the contrary, 71% of Inuit serum samples antagonized XERcomp compared to 7 – 30 % in the other regions. XER and XERcomp were not or weakly correlated to the two POP markers. XER activity of Inuit samples was negatively associated to levels of CB-153 and p,p '-DDE. For the Warsaw group a positive and negative correlation between XER and p,p' -DDE and estradiol equivalence level and CB-153 levels was found. Conclusion No strong consistent association between xenoestrogenic net activity and the two POP markers was found. The results showed that the selected POP markers alone can not predict the integrated xenoestrogenic serum activity. Correlations to the POP markers were found at the extreme edge; the Inuit's and Warsaw study groups eliciting high frequency of samples with ER antagonistic and agonistic activity, respectively. We suggest that the variation in xenoestrogenic serum activity reflects differences in POP exposure mixture, genetic factors and/or life style factors. |
format |
Article in Journal/Newspaper |
author |
Bonefeld-Jorgensen, Eva C Hjelmborg, Philip S Reinert, Thayaline S Andersen, Birgitte S Lesovoy, Vladimir Lindh, Christian H Hagmar, Lars Giwercman, Aleksander Erlandsen, Mogens Manicardi, Gian-Carlo Spanò, Marcello Toft, Gunnar Bonde, Jens Peter |
author_facet |
Bonefeld-Jorgensen, Eva C Hjelmborg, Philip S Reinert, Thayaline S Andersen, Birgitte S Lesovoy, Vladimir Lindh, Christian H Hagmar, Lars Giwercman, Aleksander Erlandsen, Mogens Manicardi, Gian-Carlo Spanò, Marcello Toft, Gunnar Bonde, Jens Peter |
author_sort |
Bonefeld-Jorgensen, Eva C |
title |
Xenoestrogenic activity in blood of European and Inuit populations |
title_short |
Xenoestrogenic activity in blood of European and Inuit populations |
title_full |
Xenoestrogenic activity in blood of European and Inuit populations |
title_fullStr |
Xenoestrogenic activity in blood of European and Inuit populations |
title_full_unstemmed |
Xenoestrogenic activity in blood of European and Inuit populations |
title_sort |
xenoestrogenic activity in blood of european and inuit populations |
publisher |
Springer Science and Business Media LLC |
publishDate |
2006 |
url |
http://dx.doi.org/10.1186/1476-069x-5-12 http://link.springer.com/content/pdf/10.1186/1476-069X-5-12.pdf http://link.springer.com/article/10.1186/1476-069X-5-12/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-5-12 https://link.springer.com/content/pdf/10.1186/1476-069X-5-12.pdf |
genre |
greenlandic inuit |
genre_facet |
greenlandic inuit |
op_source |
Environmental Health volume 5, issue 1 ISSN 1476-069X |
op_rights |
http://www.springer.com/tdm |
op_doi |
https://doi.org/10.1186/1476-069x-5-12 |
container_title |
Environmental Health |
container_volume |
5 |
container_issue |
1 |
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1766020969043853312 |