Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations
Abstract Background The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4'...
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Format: | Article in Journal/Newspaper |
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Springer Science and Business Media LLC
2005
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Online Access: | http://dx.doi.org/10.1186/1476-069x-4-27 http://link.springer.com/content/pdf/10.1186/1476-069X-4-27.pdf http://link.springer.com/article/10.1186/1476-069X-4-27/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-4-27 https://link.springer.com/content/pdf/10.1186/1476-069X-4-27.pdf |
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crspringernat:10.1186/1476-069x-4-27 2023-05-15T16:31:12+02:00 Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations Jönsson, Bo AG Rylander, Lars Lindh, Christian Rignell-Hydbom, Anna Giwercman, Aleksander Toft, Gunnar Pedersen, Henning S Ludwicki, Jan K Góralczyk, Katarzyna Zvyezday, Valentyna Spanò, Marcello Bizzaro, Davide Bonefeld-Jörgensen, Eva C Manicardi, Gian Carlo Bonde, Jens Peter Hagmar, Lars 2005 http://dx.doi.org/10.1186/1476-069x-4-27 http://link.springer.com/content/pdf/10.1186/1476-069X-4-27.pdf http://link.springer.com/article/10.1186/1476-069X-4-27/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-4-27 https://link.springer.com/content/pdf/10.1186/1476-069X-4-27.pdf en eng Springer Science and Business Media LLC http://www.springer.com/tdm Environmental Health volume 4, issue 1 ISSN 1476-069X Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health journal-article 2005 crspringernat https://doi.org/10.1186/1476-069x-4-27 2022-01-04T14:47:09Z Abstract Background The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis ( p -chlorophenyl)-ethylene (p,p'-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers. Method In study populations of 3161 adults, comprising Greenlandic Inuits, Swedish fishermen and their wives, and inhabitants from Warsaw, Poland and Kharkiv, Ukraine, serum concentrations of CB-153 and p,p'-DDE, were analysed by gas chromatography-mass spectrometry. Results The median serum concentrations of CB-153 were for male and female Inuits 200 and 110, for Swedish fishermen 190 and their wives 84, for Kharkiv men and women 44 and 27, and for Warsaw men and women 17 and 11 ng/g lipids, respectively. The median serum concentrations of p,p'-DDE were for Kharkiv men and women 930 and 650, for male and female Inuits 560 and 300, for Warsaw men and women 530 and 380, and for Swedish fishermen 240 and their wives 140 ng/g lipids, respectively. The correlation coefficients between CB-153 and p,p'-DDE varied between 0.19 and 0.92, with the highest correlation among Inuits and the lowest among men from Warsaw. Men had averagely higher serum concentrations of CB-153 and p,p'-DDE, and there were positive associations between age and the POP-biomarkers, whereas the associations with BMI and smoking were inconsistent. Dietary seafood was of importance only in the Inuit and Swedish populations. Conclusion CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p'-DDE showing highest concentrations in the Kharkiv population. The correlations between the POP-biomarkers varied considerably between the populations, underlining that exposure sources differ and that the choice of representative biomarkers of overall POP exposure has to be based on an analysis of the specific exposure situation for each population. Age and gender were consistent determinants of serum POPs; seafood was of importance only in the Inuit and Swedish populations. Article in Journal/Newspaper greenlandic inuit inuits Springer Nature (via Crossref) Environmental Health 4 1 |
institution |
Open Polar |
collection |
Springer Nature (via Crossref) |
op_collection_id |
crspringernat |
language |
English |
topic |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
spellingShingle |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Jönsson, Bo AG Rylander, Lars Lindh, Christian Rignell-Hydbom, Anna Giwercman, Aleksander Toft, Gunnar Pedersen, Henning S Ludwicki, Jan K Góralczyk, Katarzyna Zvyezday, Valentyna Spanò, Marcello Bizzaro, Davide Bonefeld-Jörgensen, Eva C Manicardi, Gian Carlo Bonde, Jens Peter Hagmar, Lars Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
topic_facet |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
description |
Abstract Background The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis ( p -chlorophenyl)-ethylene (p,p'-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers. Method In study populations of 3161 adults, comprising Greenlandic Inuits, Swedish fishermen and their wives, and inhabitants from Warsaw, Poland and Kharkiv, Ukraine, serum concentrations of CB-153 and p,p'-DDE, were analysed by gas chromatography-mass spectrometry. Results The median serum concentrations of CB-153 were for male and female Inuits 200 and 110, for Swedish fishermen 190 and their wives 84, for Kharkiv men and women 44 and 27, and for Warsaw men and women 17 and 11 ng/g lipids, respectively. The median serum concentrations of p,p'-DDE were for Kharkiv men and women 930 and 650, for male and female Inuits 560 and 300, for Warsaw men and women 530 and 380, and for Swedish fishermen 240 and their wives 140 ng/g lipids, respectively. The correlation coefficients between CB-153 and p,p'-DDE varied between 0.19 and 0.92, with the highest correlation among Inuits and the lowest among men from Warsaw. Men had averagely higher serum concentrations of CB-153 and p,p'-DDE, and there were positive associations between age and the POP-biomarkers, whereas the associations with BMI and smoking were inconsistent. Dietary seafood was of importance only in the Inuit and Swedish populations. Conclusion CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p'-DDE showing highest concentrations in the Kharkiv population. The correlations between the POP-biomarkers varied considerably between the populations, underlining that exposure sources differ and that the choice of representative biomarkers of overall POP exposure has to be based on an analysis of the specific exposure situation for each population. Age and gender were consistent determinants of serum POPs; seafood was of importance only in the Inuit and Swedish populations. |
format |
Article in Journal/Newspaper |
author |
Jönsson, Bo AG Rylander, Lars Lindh, Christian Rignell-Hydbom, Anna Giwercman, Aleksander Toft, Gunnar Pedersen, Henning S Ludwicki, Jan K Góralczyk, Katarzyna Zvyezday, Valentyna Spanò, Marcello Bizzaro, Davide Bonefeld-Jörgensen, Eva C Manicardi, Gian Carlo Bonde, Jens Peter Hagmar, Lars |
author_facet |
Jönsson, Bo AG Rylander, Lars Lindh, Christian Rignell-Hydbom, Anna Giwercman, Aleksander Toft, Gunnar Pedersen, Henning S Ludwicki, Jan K Góralczyk, Katarzyna Zvyezday, Valentyna Spanò, Marcello Bizzaro, Davide Bonefeld-Jörgensen, Eva C Manicardi, Gian Carlo Bonde, Jens Peter Hagmar, Lars |
author_sort |
Jönsson, Bo AG |
title |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_short |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_full |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_fullStr |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_full_unstemmed |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_sort |
inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (cb-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-dde): a cross-sectional study of 3161 men and women from inuit and european populations |
publisher |
Springer Science and Business Media LLC |
publishDate |
2005 |
url |
http://dx.doi.org/10.1186/1476-069x-4-27 http://link.springer.com/content/pdf/10.1186/1476-069X-4-27.pdf http://link.springer.com/article/10.1186/1476-069X-4-27/fulltext.html http://link.springer.com/content/pdf/10.1186/1476-069X-4-27 https://link.springer.com/content/pdf/10.1186/1476-069X-4-27.pdf |
genre |
greenlandic inuit inuits |
genre_facet |
greenlandic inuit inuits |
op_source |
Environmental Health volume 4, issue 1 ISSN 1476-069X |
op_rights |
http://www.springer.com/tdm |
op_doi |
https://doi.org/10.1186/1476-069x-4-27 |
container_title |
Environmental Health |
container_volume |
4 |
container_issue |
1 |
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1766020971005739008 |